Linking dioxins to diabetes: epidemiology and biologic plausibility

Rene B J Remillard, Nigel J Bunce, Rene B J Remillard, Nigel J Bunce

Abstract

Recent epidemiologic studies suggest a possible association between dioxin-like compounds (DLCs) and diabetes in human populations, although experimental links between DLCs and diabetes are lacking. The public health significance of such an association is that all populations are exposed to small but measurable levels of DLCs, chronic low-dose exposure to which may hasten the onset of adult-onset diabetes in susceptible individuals. In this article, we review the epidemiologic studies and propose biologically plausible connections between dioxins and diabetes. Specifically, we suggest that aryl hydrocarbon (Ah) receptor functions may antagonize peroxisome proliferator-activated receptor (PPAR) functions, and hence that the Ah receptor may promote diabetogenesis through a mechanism of PPAR antagonism.

References

    1. Physiol Res. 1998;47(4):215-25
    1. Horm Metab Res. 1998 Sep;30(9):543-8
    1. Environ Health Perspect. 1998 Dec;106(12):775-92
    1. Am Ind Hyg Assoc J. 1988 Sep;49(9):466-74
    1. J Toxicol Environ Health. 1988;25(4):495-507
    1. J Toxicol Environ Health. 1992 Jan;35(1):29-38
    1. Diabetes Care. 1992 Mar;15(3):369-95
    1. J Environ Sci Health B. 1992 Oct;27(5):495-510
    1. J Biol Chem. 1999 Jan 1;274(1):510-5
    1. Carcinogenesis. 1999 Jan;20(1):13-8
    1. J Biol Chem. 1999 May 7;274(19):13604-12
    1. J Toxicol Environ Health B Crit Rev. 1999 Apr-Jun;2(2):183-210
    1. J Clin Endocrinol Metab. 1999 May;84(5):1540-3
    1. Biochem J. 1999 Jul 1;341 ( Pt 1):105-11
    1. Arch Biochem Biophys. 1999 Jul 15;367(2):250-7
    1. J Biol Chem. 1999 Aug 6;274(32):22155-64
    1. Arch Toxicol. 1999 Aug;73(6):323-36
    1. Occup Environ Med. 1999 Apr;56(4):270-6
    1. FEBS Lett. 1999 Sep 3;457(3):441-4
    1. Lancet. 2000 Mar 18;355(9208):1008-10
    1. J Biol Chem. 2000 May 5;275(18):13510-6
    1. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6212-7
    1. Drugs. 2000 May;59(5):1101-11
    1. Mol Cell Biol. 2000 Aug;20(15):5433-46
    1. Food Addit Contam. 2000 Apr;17(4):289-302
    1. Toxicol Sci. 2000 Aug;56(2):431-6
    1. Prostaglandins Other Lipid Mediat. 2000 Jun;62(1):23-32
    1. Prostaglandins Other Lipid Mediat. 2000 Jun;62(1):45-73
    1. Ind Health. 2000 Jul;38(3):259-68
    1. EXS. 2000;89:141-51
    1. Andrologia. 2000 Sep;32(4-5):279-83
    1. J Biol Chem. 2000 Dec 22;275(51):39855-9
    1. Trends Pharmacol Sci. 2000 Dec;21(12):469-74
    1. Mol Endocrinol. 2000 Dec;14(12):1976-85
    1. Jpn J Pharmacol. 2000 Oct;84(2):113-23
    1. J Biol Chem. 2001 Mar 2;276(9):6695-702
    1. Traffic. 2001 Jan;2(1):2-11
    1. Toxicol Sci. 2001 Apr;60(2):327-37
    1. Mol Pharmacol. 2001 Apr;59(4):765-73
    1. Environ Sci Technol. 2001 May 1;35(9):180A-181A
    1. Nature. 1968 Nov 16;220(5168):702-3
    1. Arch Environ Health. 1972 Aug;25(2):125-31
    1. Environ Health Perspect. 1973 Sep;5:87-99
    1. Biochem Pharmacol. 1983 Sep 15;32(18):2775-9
    1. Toxicol Appl Pharmacol. 1992 Nov;117(1):126-32
    1. Exp Toxicol Pathol. 1992 Dec;44(8):473-80
    1. Diabetologia. 1999 Nov;42(11):1367-74
    1. Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209-18
    1. Epidemiology. 2000 Jan;11(1):44-8
    1. J Biol Chem. 2000 Jan 28;275(4):2943-50
    1. Mol Cell Biol. 2000 Feb;20(4):1124-33
    1. Ecotoxicol Environ Saf. 1993 Aug;26(1):45-60
    1. Occup Environ Med. 1994 Jul;51(7):479-86
    1. Mol Cell Biol. 1995 Jan;15(1):351-7
    1. Mol Pharmacol. 1995 Jan;47(1):65-73
    1. Metabolism. 1995 Feb;44(2 Suppl 2):4-9
    1. Carcinogenesis. 1995 Nov;16(11):2807-11
    1. Toxicology. 1997 Jan 15;116(1-3):9-16
    1. Toxicol Lett. 1997 Feb 7;90(2-3):145-53
    1. Epidemiology. 1997 May;8(3):252-8
    1. Mol Pharmacol. 1997 Jul;52(1):30-7
    1. Biochem Biophys Res Commun. 1997 Sep 18;238(2):338-42
    1. Biochem Biophys Res Commun. 1997 Oct 9;239(1):273-8
    1. Teratog Carcinog Mutagen. 1997-1998;17(4-5):241-7
    1. Environ Health Perspect. 1998 Apr;106 Suppl 2:625-33
    1. Toxicol Appl Pharmacol. 1998 Jul;151(1):70-8
    1. Nature. 1998 Sep 10;395(6698):137-43
    1. Toxicol Pathol. 1998 Sep-Oct;26(5):657-71
    1. J Cell Sci. 1998 Nov;111 ( Pt 22):3311-22

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