Ventilator-Induced Diaphragmatic Dysfunction: Diagnosis and Role of Pharmacological Agents
Won-Young Kim, Chae-Man Lim, Won-Young Kim, Chae-Man Lim
Abstract
The use of controlled mechanical ventilation results in a major reduction of diaphragmatic contractile force together with atrophy of diaphragm muscle fibers, which is a condition known as ventilator-induced diaphragmatic dysfunction. Ventilator-induced diaphragmatic dysfunction is one of the major contributors to weaning difficulties and even increased mortality. This review summarizes the current data on the pathogenesis and diagnosis of ventilator-induced diaphragmatic dysfunction, and it outlines the use of ultrasonography for diaphragm evaluation. In addition, current pharmacologic agents used to mitigate ventilator-induced diaphragmatic dysfunction are described, with a particular emphasis on the therapeutic potential of theophylline in patients with ventilator-induced diaphragmatic dysfunction-associated weaning difficulties.
Keywords: diaphragm; diaphragm dysfunction; mechanical ventilation; review; theophylline; ultrasonography.
Conflict of interest statement
The authors have disclosed no conflicts of interest.
Copyright © 2017 by Daedalus Enterprises.
Source: PubMed