The ability of lumbar spine DXA and phalanx QUS to detect previous fractures in young thalassemic patients with hypogonadism, hypothyroidism, diabetes, and hepatitis-B: A 2-year subgroup analysis from the Taranto Area of Apulia Region

Alberto Argentiero, Cosimo Neglia, Angelo Peluso, Salvatore di Rosa, Antonio Ferrarese, Gianluca Di Tanna, Vincenzo Caiaffa, Marco Benvenuto, Alexandru Cozma, Giovanna Chitano, Nadia Agnello, Daniele Paladini, Nicola Baldi, Alessandro Distante, Prisco Piscitelli, Alberto Argentiero, Cosimo Neglia, Angelo Peluso, Salvatore di Rosa, Antonio Ferrarese, Gianluca Di Tanna, Vincenzo Caiaffa, Marco Benvenuto, Alexandru Cozma, Giovanna Chitano, Nadia Agnello, Daniele Paladini, Nicola Baldi, Alessandro Distante, Prisco Piscitelli

Abstract

Background: Osteoporosis is a leading cause of morbidity in patients affected by β-thalassemia major or intermediate; we aimed to assess the association between demineralization observed in young thalassemic patients.

Methods: A total of 88 patients with β-thalassemia were recruited at Microcitemia Center of Taranto Hospital under the Prevention Osteoporosis and Fractures research project from 2008 to 2010. All the patients were screened with both dual energy x-ray absorptiometry (DXA) and quantitative ultrasound (QUS). T score and Z score values were obtained for each subject.

Results: The overall prevalence of demineralization was 84% with DXA and 70% with QUS, whereas normality was found in 16% of patients screened with DXA and in 30% of cases with QUS. Hypogonadism, hypothyroidism, diabetes mellitus, hepatitis-B, and the presence of previous fragility fractures were significantly associated with the demineralization status (lower T scores values) both with DXA and QUS.

Conclusion: Our data confirm that DXA and QUS examinations are both useful for detecting bone demineralization in thalassemic patients.

Conflict of interest statement

P.P. has received consulting fees from Amgen-Dompè, Sanofi-Aventis, Eli-Lilly, and Servier. For the remaining authors none were declared.

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