The role of ischemia modified albumin in acute pulmonary embolism

Zeynettin Kaya, M Kayrak, E E Gul, G Altunbas, A Toker, A Kiyici, M Gunduz, H Alibaşiç, H Akilli, A Aribas, Zeynettin Kaya, M Kayrak, E E Gul, G Altunbas, A Toker, A Kiyici, M Gunduz, H Alibaşiç, H Akilli, A Aribas

Abstract

Background: Acute pulmonary embolism (PE) is a life-threatening and a relatively common cardiovascular pathology. Although the pathogenesis of PE is well defined, there is no ideal diagnostic biochemical marker. Previous studies showed an increased ischemia modified albumin (IMA) levels in acute PE; however, the relationship between IMA and right ventricular (RV) dysfunction has not been examined. The aim of this study was to evaluate the diagnostic value of IMA and the relationship with RV dysfunction in acute PE.

Materials and methods: A total of 145 patients (70 females) with suspected acute PE was enrolled to the study. Eighty-nine patients were diagnosed with acute PE via computed tomographic pulmonary angiography. Sixty-five patients with similar demographic and clinical characteristics were assigned to the control group. All patients were evaluated for RV dysfunction using transthoracic echocardiography.

Results: Serum IMA levels were significantly increased in acute PE compared with control group (0.41 ± 0.06 vs. 0.34 ± 0.11, P = 0.001). There was no relationship between serum IMA levels and RV dysfunction. IMA levels were positively correlated with shock index and heart rate. Receiver operating curve analysis demonstrated that serum IMA levels higher than 0.4 put the diagnosis at sensitivity of 53.85% and at specificity of 85.96%.

Conclusions: Although IMA levels are increased in patients with acute PE, it failed to predict RV dysfunction.

Keywords: Acute pulmonary embolism; echocardiography; ischemia modified albumin; right ventricular dysfunction.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Serum ischemia modified albumin levels of patients with acute pulmonary embolism and control group
Figure 2
Figure 2
Comparison of serum ischemia modified albumin levels in patients with acute pulmonary embolism with and without right ventricular dysfunction
Figure 3
Figure 3
Receiver operating curve analysis showing specificity and sensitivity of serum ischemia modified albumin levels in the diagnosis of acute pulmonary embolism

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