Vasomotor and physical menopausal symptoms are associated with sleep quality

Min-Ju Kim, Gyeyoon Yim, Hyun-Young Park, Min-Ju Kim, Gyeyoon Yim, Hyun-Young Park

Abstract

Background: Sleep disturbance is one of the common complaints in menopause. This study investigated the relationship between menopausal symptoms and sleep quality in middle-aged women.

Method: This cross-sectional observational study involved 634 women aged 44-56 years attending a healthcare center at Kangbuk Samsung Hospitals. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI).Multiple linear regression analysis was performed to assess the associations between Menopause-specific Quality of Life (MENQOL) scores and PSQI scores and Menopause-specific Quality of Life (MENQOL)scores.

Results: The mean PSQI score was 3.6±2.3, and the rates of poor sleep quality(PSQI score > 5) in premenopausal, perimenopausal, and postmenopausal women were 14.4%, 18.2%, and 30.2%, respectively. Total PSQI score, specifically the sleep latency, habitual sleep efficiency and sleep disturbances scores, were significantly increased in postmenopausal women. Multiple linear regression analysis adjusted for age, BMI, hypertension, diabetes, smoking, marital status, family income, education, employment status, parity, physical activity, depression symptoms, perceived stress and menopausal status showed that higher PSQI score was positively correlated with higher vasomotor(ß = 0.240, P = 0.020)and physical(ß = 0.572, P<0.001) scores.

Conclusions: Vasomotor and physical menopause symptoms was related to poor sleep quality. Effective management strategies aimed at reducing menopausal symptoms may improve sleep quality among women around the time of menopause.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. Guidozzi F. Sleep and sleep disorders in menopausal women. Climacteric. 2013;16:214–219. doi:
    1. Owens JF, Matthews KA. Sleep disturbance in healthy middle-aged women. Maturitas.1998;30:41–50.
    1. Prather AA, Puterman E, Epel ES, Dhabhar FS. Poor sleep quality potentiates stress-induced cytokine reactivity in postmenopausal women with high visceral abdominal adiposity. Brain Behav Immun.2014;35:155–162. doi:
    1. Sands-Lincoln M, Loucks EB, Lu B, Carskadon MA, Sharkey K, Stefanick ML,et al. Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J Womens Health (Larchmt).2013;22:477–486.
    1. Gallicchio L, Kalesan B. Sleep duration and mortality: a systematic review and meta-analysis. J Sleep Res.2009;18:148–158. doi:
    1. Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J.2011;32:1484–1492. doi:
    1. Regestein Q, Natarajan V, Pavlova M, Kawasaki S, Gleason R, Koff E. Sleep debt and depression in female college students. Psychiatry Res. 2010;176:34–39. doi:
    1. Baker FC, Wolfson AR, Lee KA. Association of sociodemographic, lifestyle, and health factors with sleep quality and daytime sleepiness in women: findings from the 2007 National Sleep Foundation "Sleep in America Poll". J Womens Health (Larchmt).2009;18:841–849.
    1. Monterrosa-Castro A, Marrugo-Flórez M, Romero-Pérez I, Fernández-Alonso AM, Chedraui P, Pérez-López FR. Assessment of sleep quality and correlates in a large cohort of Colombian women around menopause. Menopause.2013;20:464–469. doi:
    1. Sun D, Shao H, Li C, Tao M. Sleep disturbance and correlates in menopausal women in Shanghai. J Psychosom Res.2014;76:237–241. doi:
    1. Kravitz HM, Ganz PA, Bromberger J, Powell LH, Sutton-Tyrrell K, Meyer PM. Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition. Menopause.2003;10:19–28.
    1. Kuh DL, Wadsworth M, Hardy R. Women's health in midlife: the influence of the menopause, social factors and health in earlier life. Br J ObstetGynaecol.1997;104:923–933.
    1. Cuadros JL, Fernández-Alonso AM, Cuadros-Celorrio AM, Fernández-Luzón N, Guadix-Peinado MJ, del Cid-Martín N, et al. Perceived stress, insomnia and related factors in women around the menopause. Maturitas.2012;72:367–372. doi:
    1. Cheng MH, Hsu CY, Wang SJ, Lee SJ, Wang PH, Fuh JL. The relationship of self-reported sleep disturbance, mood, and menopause in a community study. Menopause.2008;15:958–962. doi:
    1. Seib C, Anderson D, Lee K. Prevalence and correlates of sleep disturbance in postmenopausal women: the Australian Healthy Aging of Women (HOW) Study. J Womens Health (Larchmt).2014;23:151–158.
    1. Stranges S1, Dorn JM, Cappuccio FP, Donahue RP, Rafalson LB, Hovey KM, et al. A population-based study of reduced sleep duration and hypertension: the strongest association may be in premenopausal women. J Hypertens.2010;28:896–902. doi:
    1. Moreno-Frías C, Figueroa-Vega N, Malacara JM. Relationship of sleep alterations with perimenopausal and postmenopausal symptoms. Menopause.2014;21:1017–1022. doi:
    1. Polo-Kantola P, Erkkola R, Irjala K, Helenius H, Pullinen S, Polo O. Climacteric symptoms and sleep quality. Obstet Gynecol.1999;94:219–224.
    1. Kim MJ, Cho J, Ahn Y, Yim G, Park HY. Association between physical activity and menopausal symptoms in perimenopausal women. BMC Womens Health.2014;14:122 doi:
    1. Radloff Lenore Sawyer. The CES-D scale a self-report depression scale for research in the general population. Applied psychological measurement.1977;1:385–401.
    1. Cho MJ, Kim KH. Use of the Center for Epidemiologic Studies Depression (CES-D) Scale in Korea. J NervMent Dis.1998;186:304–310.
    1. Shin HC. Measuring stress with questionnaires. J Korean Med Assoc. 2013;56: 485–495.
    1. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging. Climacteric.2012;15:105–114. doi:
    1. Hilditch JR, Lewis J, Peter A, van Maris B, Ross A, Franssen E, et al. A menopause-specific quality of life questionnaire: development and psychometric properties. Maturitas.2008;61:107–121.
    1. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res.1989;28:193–213.
    1. Chung KF, Tang MK. Subjective sleep disturbance and its correlates in middle-aged Hong Kong Chinese women. Maturitas.2006;53:396–404. doi:
    1. Li RH, Wing YK, Ho SC, Fong SY. Gender differences in insomnia—a study in the Hong Kong Chinese population. J Psychosom Res.2002;53:601–609.
    1. Shin C, Lee S, Lee T, Shin K, Yi H, Kimm K, et al. Prevalence of insomnia and its relationship to menopausal status in middle-aged Korean women. Psychiatry ClinNeurosci.2005;59:395–402.
    1. Blümel JE, Cano A, Mezones-Holguín E,Barón G, Bencosme A, Benítez Z, et al. A multinational study of sleep disorders during female mid-life. Maturitas.2012;72:359–366. doi:
    1. Vousoura E, Spyropoulou AC, Koundi KL, Tzavara C, Verdeli H, Paparrigopoulos T, et al. Vasomotor and depression symptoms may be associated with different sleep disturbance patterns in postmenopausal women. Menopause.2015;22:1053–1057. doi:
    1. Ameratunga D, Goldin J, Hickey M. Sleep disturbance in menopause. Intern Med J.2012;42:742–747. doi:
    1. Schiff I, Regestein Q, Tulchinsky D, Ryan KJ. Effects of estrogens on sleep and psychological state of hypogonadal women. JAMA.1979;242:2405–2407.
    1. Thomson J, Oswald I. Effect of oestrogen on the sleep, mood, and anxiety of menopausal women. Br Med J. 1977;2:1317–1319.
    1. Moe KE, Larsen LH, Vitiello MV, Prinz PN. Estrogen replacement therapy moderates the sleep disruption associated with nocturnal blood sampling. Sleep.2001;24:886–894.
    1. Sarti CD, Chiantera A, Graziottin A,Ognisanti F, Sidoli C, Mincigrucci M, et al.Hormone therapy and sleep quality in women around menopause. Menopause.2005;12:545–551. doi:
    1. Krystal AD, Edinger J, Wohlgemuth W, Marsh GR. Sleep in peri-menopausal and post-menopausal women. Sleep Med Rev.1998;2:243–253.
    1. Polo-Kantola P, Erkkola R, Helenius H, Irjala K, Polo O. When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol.1998;178:1002–1009.
    1. Polo. Partial upper airway obstruction during sleep. Studies with the static charge-sensitive bed (SCSB). ActaPhysiolScand Suppl. 1992;145:1–118.
    1. Guilleminault C, Quera-Salva MA, Partinen M, Jamieson A. Women and the obstructive sleep apnea syndrome. Chest. 1988;93:104–109.

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