Interleukin-6 Kinetics can be Useful for Early Treatment Monitoring of Severe Bacterial Sepsis and Septic Shock
Thomas Klag, Giulio Cantara, Udo Sechtem, Anastasios Athanasiadis, Thomas Klag, Giulio Cantara, Udo Sechtem, Anastasios Athanasiadis
Abstract
Early appropriate anti-microbial therapy is necessary to improve outcomes of septic patients. We describe 20 case histories of patients with severe bacterial sepsis regarding kinetics of several biomarkers. We found that interleukin-6 is able to predict survival and might be able to evaluate appropriateness of anti-microbial therapy.
Keywords: C reactive protein; Interleukin-6; bacterial sepsis; monitoring; procalcitonin.
Conflict of interest statement
Conflict of interest: the authors declare no potential conflict of interest.
Figures
Relative biomarker kinetics of IL-6, CRP, PCT and WBC for survivors and non-survivors in the first 72 hours after start of sepsis therapy. Values are plotted relatively, as fold change of baseline values (all mean values). For statistical testing the paired two-tailed t-test was used. A P
References
- Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013;369:840-51.
- De Santis V, Gresoiu M, Corona A, et al. Bacteraemia incidence, causative organisms and resistance patterns, antibiotic strategies and outcomes in a single university hospital ICU: continuing improvement between 2000 and 2013. J Antimicrob Chemother 2015;70:273-8.
- Burns J. Do health plans have a role in limiting antibiotic resistance? Manag Care 2014;23:26-33.
- Davies SW, Efird JT, Guidry CA, et al. Characteristics of surgical patients receiving inappropriate empiric antimicrobial therapy. J Trauma Acute Care Surg 2014;77:546-54.
- Rodriguez-Maresca M, Sorlozano A, Grau M, et al. Implementation of a computerized decision support system to improve the appropriateness of antibiotic therapy using local microbiologic data. Biomed Res Int 2014;2014:395434.
- Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci 2013;50:23-36.
- Sridharan P, Chamberlain RS. The efficacy of procalcitonin as a biomarker in the management of sepsis: slaying dragons or tilting at windmills? Surg Infect (Larchmt) 2013;14:489-511.
- Jensen JU, Hein L, Lundgren B, et al. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med 2011;39:2048-58.
- Jekarl DW, Lee SJ, Lee J, et al. Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis. Diagn Microbiol Infect Dis 2013;75:342-7.
Source: PubMed