Effects of a Novel Dental Gel on Plaque and Gingivitis: A Comparative Study

M Dadkhah, N E Chung, J Ajdaharian, C Wink, P Klokkevold, P Wilder-Smith, M Dadkhah, N E Chung, J Ajdaharian, C Wink, P Klokkevold, P Wilder-Smith

Abstract

Objectives: The goal of this prospective, randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on plaque and gingival health. The dental gel was designed to (1) break up and prevent re-accumulation of microbial biofilm, and (2) inhibit metal mediated inflammation.

Materials and methods: Twenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥2) and pocket depths <4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. On Days 0, 7, 14 and 21, plaque levels (Quigley-Hein, Turesky Modification Plaque Index), gingival inflammation (Löe and Silness Gingival Index) and gingival bleeding (modified Sulcus Bleeding Index) were determined by one blinded, investigator using a pressure sensitive probe.

Results: After 3 weeks, all 3 clinical indices were significantly improved in both groups (P<0.05) and significantly lower in the test group (P<0.05).

Conclusion: The novel dental gel formulation was provided effective plaque control and reduced gingival inflammation.

Clinical relevance: A novel dentifrice formulation may be an effective tool for plaque removal and maintaining gingival health.

Keywords: Biofilm; Dentifrice; Gingival inflammation; Oral hygiene; Plaque.

Conflict of interest statement

We confirm that there are no conflicts of interest for any of the authors of this paper.

Figures

Figure 1. Plaque Index at Baseline, Day…
Figure 1. Plaque Index at Baseline, Day 7, Day 14, and Day 21. The error bars indicate the standard error of the mean (σ/√n)
Figure 2. Modified Sulcus Bleeding Index (mSBI)…
Figure 2. Modified Sulcus Bleeding Index (mSBI) at Baseline, Day 7, Day 14, and Day 21. The error bars indicate the standard error of the mean (σ/√n)
Figure 3. Gingival Index at Baseline, Day…
Figure 3. Gingival Index at Baseline, Day 7, Day 14, and Day 21. The error bars indicate the standard error of the mean (σ/√n)

References

    1. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994;5:78–111.
    1. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ, et al. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914–920.
    1. Theilade E, Wright WH, Jensen SB, Löe H. Experimental Gingivitis in Man. II. A Longitudinal Clinical and Bacteriological Investigation. J Periodontal Res. 1996;1:1–13.
    1. Axelsson P, Lindhe J. The Significance of Maintenance Care in the Treatment of Periodontal Disease. J Clin Periodontol. 1981;8:281–294.
    1. Morris AJ, Steele J, White DA. The Oral Cleanliness and Periodontal Health of UK Adults in 1998. Br Dent J. 2001;191:186–192.
    1. Nogueira-Filho GR, Toledo S. Effect of Three Dentifrices Containing Triclosan and Various Additives. An Experimental Gingivitis Study. J Clin Periodontol. 2000;27:494–498.
    1. Van der Weijden GA, Hioe KP. A Systematic Review of the Effectiveness of Self-performed Mechanical Plaque Removal in Adults with Gingivitis Using a Manual Toothbrush. J Clin Periodontol. 2005;32:6214–6228.
    1. Yates R, Jenkins S, Newcombe R, Wade W, Moran J, et al. A 6-month Home Usage Trial of a 1% Chlorhexidine Toothpaste (1). Effects on Plaque, Gingivitis, Calculus and Toothstaining. J Clin Periodontol. 1993;20:130–138.
    1. Madlena M, Banoczy J, Gotz G, Marton S, Kaan M, et al. Effects of Amine and Stannous Fluorides on Plaque Accumulation and Gingival Health in Orthodontic Patients Treated with Fixed Appliances: A Pilot Study. Oral Health Dent Manag. 2012;11:57–61.
    1. Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc. 2006;137:1649–1657.
    1. Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, et al. Clinical and Microbiologic Changes Associated With the Combined Use of a Powered Toothbrush and a Triclosan/Copolymer Dentifrice: A 3-Year Prospective Study. J Periodontol. 2007;78:1708–1717.
    1. Raut SA, Angus RA. Triclosan Has Endocrine-disrupting Effects in Male Western Mosquitofish, Gambusia affinis. Environ Toxicol Chem. 2010;29:1287–1291.
    1. Dodson RE, Nishioka M, Standley LJ, Perovich LJ, Brody JG, et al. Endocrine Disruptors and Asthma-Associated Chemicals in Consumer Products. Environ Health Perspect. 2012;120:935–943.
    1. Yazdankhah SP, Scheie AA, Høiby EA, Lunestad BT, Heir E, et al. Triclosan and antimicrobial resistance in bacteria: an overview. Microb Drug Resist. 2006;12:83–90.
    1. Fang X, Keutgen XM, Jiang Y, Sherertz R, Hachem R. The Role of Chelators in Preventing Biofilm Formation and Catheter-Related Bloodstream Infections. Curr Opin Infect Dis. 2008;21:385–392.
    1. Kell D. Towards a Unifying, Systems Biology Understanding of Large-Scale Cellular Death and Destruction Caused by Poorly Liganded Iron: Parkinson's, Huntington's, Alzheimer's, Prions, Bactericides, Chemical Toxicology and Others as Examples. Arch Toxicol. 2010;84:825–889.
    1. Ansari NH, Campbell G, Shoeb M, Xiao TL, Zhang M. Inhibition of Endotoxin-Induced Uveitis by a Metal Chelator. ARVO; 2007. p. E-5156.
    1. Zhang M, Shoeb M, Liu P, Xiao T, Hogan D, et al. Topical Metal Chelation Therapy Ameliorates Oxidation-Induced Toxicity in Diabetic Cataract. J Toxicol Environ Health A. 2011;74:380–391.
    1. Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967;38:610–616.
    1. Löe H, Silness J. Periodontal disease in pregnancy. Acta Odontologica Scandinavica. 1963;21:533–551.
    1. Turesky S, Gilmore ND, Glickman I. Reduced Plaque Formation by the Chloromethyl Analogue of Victamine C. J Periodontol. 1970;41:41–43.
    1. Newbrun Indices to measure gingival bleeding. J Periodontol. 1996;67:555–561.
    1. Nightingale K, Chinta S, Agarwal P, Nemelivsky M, Frisina A, et al. Toothbrush efficacy for plaque removal. Int J Dent Hyg 2014
    1. Nathoo S, Mankodi S, Mateo LR, Chaknis P, Panagakos F. A clinical study comparing the supragingival plaque and gingivitis efficacy of a specially engineered sonic powered toothbrush with unique sensing and control technologies to a commercially available manual flat-trim toothbrush. J Clin Dent 2012
    1. Sowinski J, Petrone DM, Wachs GN, Chaknis P, Kemp J, et al. Efficacy of three toothbrushes on established gingivitis and plaque. Am J Dent. 2008;21:339–345.
    1. Chang Y, Gu W, McLandsborough L. Low Concentration of thylenediaminetetraacetic Acid (EDTA) Affects Biofilm Formation of Listeria Monocytogenes by Inhibiting Its Initial Adherence. Food Microbiol. 2011;29:10–17.
    1. Bryce G, O'Donnell D, Ready D, Ng YL, Pratten J, et al. Contemporary Root Canal Irrigants Are Able to Disrupt and Eradicate Single- And Dual-Species Biofilms. J Endod. 2009;35:1243–1248.
    1. Zhang M, Wong IG, Gin JB, Ansari NH. Assessment of Methylsulfonylmethane as a Permeability Enhancer for Regional EDTA Chelation Therapy. Drug Delivery. 2009;16:243–248.
    1. Ansari NH, Campbell G, Xiao TL, Zhang M. Amelioration of Oxidation-Induced Toxicity in Human Lens Epithelial Cells and Diabetic Rat Lens by EDTA. ARVO; 2007. p. E-2434.
    1. Hioe KP, van der Weijden GA. The effectiveness of self-performed mechanical plaque control with triclosan containing dentifrices. Int J Dent Hyg. 2005;3:192–204.

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