Effect of mini-dose dexmedetomidine supplemented intravenous analgesia on sleep structure in older patients after major noncardiac surgery: A randomized trial
Ze-Fei Zhang, Xian Su, Yi Zhao, Chong-Lin Zhong, Xiao-Qian Mo, Rui Zhang, Kun Wang, Sai-Nan Zhu, Yan-E Shen, Cheng Zhang, Dong-Xin Wang, Ze-Fei Zhang, Xian Su, Yi Zhao, Chong-Lin Zhong, Xiao-Qian Mo, Rui Zhang, Kun Wang, Sai-Nan Zhu, Yan-E Shen, Cheng Zhang, Dong-Xin Wang
Abstract
Study objectives: In previous studies, low-dose dexmedetomidine supplemented opioid analgesia improved sleep architecture but increased sedation level. Herein we tested the hypothesis that mini-dose dexmedetomidine supplemented analgesia improves sleep structure without increasing sedation.
Methods: In this randomized trial, 118 older patients (≥65 years) following major noncardiac surgery were randomized to receive patient-controlled intravenous analgesia supplemented with either placebo or dexmedetomidine (median 0.02 μg kg-1 h-1) for up to 3 days. Polysomnogram was monitored from 9:00 p.m. on the day of surgery until 6:00 a.m. on the first day after surgery. Our primary outcome was the percentage of non-rapid eye movement stage 2 (N2) sleep. Secondary outcomes included other sleep structure parameters during the night of surgery and the sedation score during the first five postoperative days.
Results: All 118 patients completed the study; of these, 85 were included in sleep structure analysis. Dexmedetomidine supplemented analgesia increased the percentage of N2 sleep (median difference, 10%; 95% CI, 1%-20%; P = 0.03). It also prolonged total sleep time (median difference, 78 min; 95% CI, 21 to 143; P = 0.01), increased sleep efficiency (median difference, 14%; 95% CI, 4%-26%; P = 0.01), decreased percentage of N1 sleep (median difference, -10%; 95% CI, -20% to -1%; P = 0.04), and lowered sleep fragmentation index (median difference, -1.6 times⋅h-1; 95% CI, -3.7 to 0.1; P = 0.04). Sedation score within 5 days did not differ between the two groups.
Conclusions: Supplementing intravenous analgesia with mini-dose dexmedetomidine improved sleep structure without increasing sedation in older patients recovering from major surgery.
Clinical trials: www.
Clinicaltrials: gov (NCT03117790), registered 2 April 2017.
Keywords: Dexmedetomidine; Elderly; Noncardiac surgery; Polysomnography; Sleep quality.
Conflict of interest statement
Declaration of competing interest None.
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Source: PubMed