Spatial and Temporal Locomotor Learning in Mouse Cerebellum
Dana M Darmohray, Jovin R Jacobs, Hugo G Marques, Megan R Carey, Dana M Darmohray, Jovin R Jacobs, Hugo G Marques, Megan R Carey
Abstract
Stable and efficient locomotion requires the precise coordination of movement across the limbs and body. Learned changes in interlimb coordination can be induced by exposure to a split-belt treadmill that imposes different speeds under each side of the body. Here, we demonstrate locomotor learning on a split-belt treadmill in mice. Mouse locomotor adaptation is specific to measures of interlimb coordination, has spatial and temporal components that adapt at different rates, and is context specific. The many similarities between human and mouse locomotor adaptation suggest that this form of locomotor learning is highly conserved across vertebrates. Using a variety of approaches, we demonstrate that split-belt adaptation in mice specifically depends on the intermediate cerebellum but is insensitive to large lesions of the cerebral cortex. Finally, cell-type-specific chemogenetics combined with quantitative behavioral analysis reveals that spatial and temporal components of locomotor adaptation are dissociable on the circuit level. VIDEO ABSTRACT.
Copyright © 2019. Published by Elsevier Inc.
Source: PubMed