The Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action

O Ethgen, C Beaudart, F Buckinx, O Bruyère, J Y Reginster, O Ethgen, C Beaudart, F Buckinx, O Bruyère, J Y Reginster

Abstract

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The reported prevalence estimates were interpolated between 65 and 100 years. Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until 2045. Using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia would rise in Europe from 10,869,527 in 2016 to 18,735,173 in 2045 (a 72.4% increase). This corresponds to an overall prevalence of sarcopenia in the elderly rising from 11.1% in 2016 to 12.9% in 2045. With the definition providing the highest prevalence estimates, the number of individuals with sarcopenia would rise from 19,740,527 in 2016 to 32,338,990 in 2045 (a 63.8% increase), corresponding to overall prevalence rates in the elderly of 20.2% and 22.3% for 2016 and 2045, respectively. We showed that the number of sarcopenic patients will dramatically increase in the next 30 years, making consequences of muscle wasting a major public health issue.

Keywords: Burden of disease; Prevalence; Public health; Sarcopenia.

Conflict of interest statement

Conflict of interest

O. Ethgen, C. Beaudart, F. Buckinx, O. Bruyère and J.Y. Reginster declare that they have no conflicts of interest pertaining this particular manuscript.

Human and Animal Rights and Informed Consent

For this type of study formal consent is not required.

Figures

Fig. 1
Fig. 1
Prevalence of sarcopenia according to the different cutoffs of the EWGSOP definition
Fig. 2
Fig. 2
Age- and gender-specific interpolation of sarcopenia prevalence using Logistic equation
Fig. 3
Fig. 3
Projected prevalence of sarcopenia in Europe from 2016 to 2045 according to the highest and the lowest definition variants (dotted boxes and lines represent the ±20% sensitivity analyses)
Fig. 4
Fig. 4
Proportion of men and women among prevalent cases of sarcopenia from 2016 to 2045 and according to the highest and the lowest definition variants

References

    1. Cruz-Jentoft AJ, Landi F. Sarcopenia. Clin Med (Lond) 2014;14:183–186. doi: 10.7861/clinmedicine.14-2-183.
    1. Reginster JY, Cooper C, Rizzoli R, Kanis JA, Appelboom G, Bautmans I, Bischoff-Ferrari HA, Boers M, Brandi ML, Bruyere O, Cherubini A, Flamion B, Fielding RA, Gasparik AI, Van Loon L, McCloskey E, Mitlak BH, Pilotto A, Reiter-Niesert S, Rolland Y, Tsouderos Y, Visser M, Cruz-Jentoft AJ. Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia. Aging Clin Exp Res. 2016;28:47–58. doi: 10.1007/s40520-015-0517-y.
    1. Cao L, Morley JE. Sarcopenia is recognized as an independent condition by an international classification of disease, tenth revision, clinical modification (ICD-10-CM) code. J Am Med Dir Assoc. 2016;17:675–677. doi: 10.1016/j.jamda.2016.06.001.
    1. Cooper C, Dere W, Evans W, Kanis JA, Rizzoli R, Sayer AA, Sieber CC, Kaufman JM, Abellan van Kan G, Boonen S, Adachi J, Mitlak B, Tsouderos Y, Rolland Y, Reginster JY. Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int. 2012;23:1839–1848. doi: 10.1007/s00198-012-1913-1.
    1. Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB, Health ABCSI. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602–1609. doi: 10.1046/j.1532-5415.2003.51534.x.
    1. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older P Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on sarcopenia in older people. Age Ageing. 2010;39:412–423. doi: 10.1093/ageing/afq034.
    1. Batsis JA, Barre LK, Mackenzie TA, Pratt SI, Lopez-Jimenez F, Bartels SJ. Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: dual-energy X-ray absorptiometry data from the National Health and Nutrition Examination Survey 1999–2004. J Am Geriatr Soc. 2013;61:974–980. doi: 10.1111/jgs.12260.
    1. Beaudart C, Reginster JY, Slomian J, Buckinx F, Locquet M, Bruyere O. Prevalence of sarcopenia: the impact of different diagnostic cut-off limits. J Musculoskelet Neuronal Interact. 2014;14:425–431.
    1. Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr. 2012;31:652–658. doi: 10.1016/j.clnu.2012.02.007.
    1. Chang SF, Lin PL. Systematic literature review and meta-analysis of the association of sarcopenia with mortality. Worldviews Evid Based Nurs. 2016;13:153–162. doi: 10.1111/wvn.12147.
    1. da Silva Alexandre T, de Oliveira Duarte YA, Ferreira Santos JL, Wong R, Lebrao ML. Sarcopenia according to the European working group on sarcopenia in older people (EWGSOP) versus dynapenia as a risk factor for disability in the elderly. J Nutr Health Aging. 2014;18:547–553. doi: 10.1007/s12603-014-0465-9.
    1. Beaudart C, Rizzoli R, Bruyere O, Reginster JY, Biver E. Sarcopenia: burden and challenges for public health. Arch Public Health. 2014;72:45. doi: 10.1186/2049-3258-72-45.
    1. Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2004;52:80–85. doi: 10.1111/j.1532-5415.2004.52014.x.
    1. Reginster JY, Beaudart C, Buckinx F, Bruyere O. Osteoporosis and sarcopenia: two diseases or one? Curr Opin Clin Nutr Metab Care. 2016;19:31–36. doi: 10.1097/MCO.0000000000000230.
    1. Eurostat EUROPOP13 database, main scenario.
    1. Raftery AE, Chunn JL, Gerland P, Sevcikova H. Bayesian probabilistic projections of life expectancy for all countries. Demography. 2013;50:777–801. doi: 10.1007/s13524-012-0193-x.
    1. Morley JE, Anker SD, von Haehling S. Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014. J Cachexia Sarcopenia Muscle. 2014;5:253–259. doi: 10.1007/s13539-014-0161-y.
    1. Landi F, Cruz-Jentoft AJ, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. Age Ageing. 2013;42:203–209. doi: 10.1093/ageing/afs194.
    1. Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. Tools in the assessment of sarcopenia. Calcif Tissue Int. 2013;93:201–210. doi: 10.1007/s00223-013-9757-z.
    1. Beaudart C, Reginster JY, Slomian J, Buckinx F, Dardenne N, Quabron A, Slangen C, Gillain S, Petermans J, Bruyere O. Estimation of sarcopenia prevalence using various assessment tools. Exp Gerontol. 2015;61:31–37. doi: 10.1016/j.exger.2014.11.014.
    1. Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY, Force ET. The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Maturitas. 2014;79:122–132. doi: 10.1016/j.maturitas.2014.07.005.
    1. Marzetti E, Calvani R, Landi F, Hoogendijk EO, Fougere B, Vellas B, Pahor M, Bernabei R, Cesari M, Consortium S Innovative medicines initiative: the SPRINTT project. J Frailty Aging. 2015;4:207–208.
    1. Chale A, Cloutier GJ, Hau C, Phillips EM, Dallal GE, Fielding RA. Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults. J Gerontol A Biol Sci Med Sci. 2013;68:682–690. doi: 10.1093/gerona/gls221.
    1. Landi F, Calvani R, Tosato M, Martone AM, Ortolani E, Savera G, D’Angelo E, Sisto A, Marzetti E (2016) Protein intake and muscle health in old age: from biological plausibility to clinical evidence. Nutrients 8:295. doi:10.3390/nu8050295
    1. Becker C, Lord SR, Studenski SA, Warden SJ, Fielding RA, Recknor CP, Hochberg MC, Ferrari SL, Blain H, Binder EF, Rolland Y, Poiraudeau S, Benson CT, Myers SL, Hu L, Ahmad QI, Pacuch KR, Gomez EV, Benichou O, Group S Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial. Lancet Diabetes Endocrinol. 2015;3:948–957. doi: 10.1016/S2213-8587(15)00298-3.
    1. Zanandrea V, Giua R, Costanzo L, Vellas B, Zamboni M, Cesari M. Interventions against sarcopenia in older persons. Curr Pharm Des. 2014;20:5983–6006. doi: 10.2174/1381612820666140316132246.
    1. Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int. 2016;98:319–333. doi: 10.1007/s00223-015-0022-5.
    1. Seidell JC, Halberstadt J. The global burden of obesity and the challenges of prevention. Ann Nutr Metab. 2015;66(Suppl 2):7–12. doi: 10.1159/000375143.
    1. Laskey MA. Dual-energy X-ray absorptiometry and body composition. Nutrition. 1996;12:45–51. doi: 10.1016/0899-9007(95)00017-8.

Source: PubMed

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