PrEP awareness and decision-making for Latino MSM in San Antonio, Texas

Moctezuma García, Allyssa L Harris, Moctezuma García, Allyssa L Harris

Abstract

Pre-Exposure Prophylaxis (PrEP) has been promoted among high-risk populations as an effective HIV biomedical intervention. However, limited research is available on the significance of culturally informed biomedical interventions for Latino MSM. A total of 159 self-administered Internet surveys were completed by Latino MSM ages 21-30 in San Antonio, Texas. The purpose of this research was to develop an instrument that measured Latino MSM attitudes and beliefs towards PrEP, identify associations between demographic factors and PrEP related factors and to suggest culturally appropriate strategies for the promotion of PrEP among the Latino MSM population. Research findings revealed implications for PrEP at the structural and individual level for Latino MSM. Structural level indicators emphasized the importance for raising PrEP awareness among Latino MSM in regards to PrEP related expenses, ameliorating stigmatization of high-risk populations, enhancing access to PrEP informed medical providers, and address mistrust of the government and medical providers role on addressing health disparities among Latino MSM. Overall, the findings for individual factors emphasize the need for patient-centered interventions for Latino MSM. Latino MSM currently on PrEP require supplemental resources to enhance PrEP adherence. Latino MSM not on PrEP require alternate options for PrEP delivery and/or cognitive behavioral approaches minimizing HIV risk behavior for Latino MSM concerned with PrEP toxicity, which may require non-biomedical interventions. Integration of Latino MSM currently on PrEP as peer educators provides a valuable resource for developing culturally informed PrEP interventions for Latino MSM. Peer educators are able to share their experiential knowledge of PrEP contextualized through cultural norms, beliefs, and values.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. Latino MSM (N = 159)…
Fig 1. Latino MSM (N = 159) decision-making factors for taking (currently on PrEP) or considering PrEP (not currently on PrEP).
Fig 2. PrEP associated stigmas for Latino…
Fig 2. PrEP associated stigmas for Latino MSM (N = 159).
Fig 3. Latino MSM (not currently on…
Fig 3. Latino MSM (not currently on PrEP) unwilling to take PrEP due to potential side effects.
Fig 4. Latino MSM (not currently on…
Fig 4. Latino MSM (not currently on PrEP) perceptions associated with the government and medical provider regarding PrEP.
Fig 5. Latino MSM (not currently on…
Fig 5. Latino MSM (not currently on PrEP) willing to take PrEP due to the required treatment regimen for taking PrEP daily, getting an HIV and blood tests every 3 months.

References

    1. FDA. FDA approves first drug for reducing the risk of sexually acquired HIV infection. 2012 [Available from: .
    1. CDC. Pre-Exposure Prophylaxis (PrEP). 2016 [Available from: .
    1. CDC. CDC's New High-Impact Approach to HIV Prevention Funding for Health Departments Advancing the National HIV/AIDS Strategy. 2014 [Available from: .
    1. Liu AY, Kittredge PV, Vittinghoff E, Raymond HF, Ahrens K, Matheson T, et al. Limited knowledge and use of HIV post-and pre-exposure prophylaxis among gay and bisexual men. Journal of Acquired Immune Deficiency Syndromes. 2008;47(2):241–7.
    1. Mimiaga MJ, Case P, Johnson CV, Safren SA, Mayer KH. Preexposure antiretroviral prophylaxis attitudes in high-risk Boston area men who report having sex with men: limited knowledge and experience but potential for increased utilization after education. Journal of Acquired Immune Deficiency Syndromes. 1999;50(1).
    1. Krakower DS, Mimiaga MJ, Rosenberger JG, Novak DS, Mitty JA, White JM, et al. Limited awareness and low immediate uptake of pre-exposure prophylaxis among men who have sex with men using an internet social networking site. PLoS One. 2012;7(3).
    1. Raifman JR, Flynn C, German D. Healthcare provider contact and pre-exposure prophylaxis in Baltimore men who have sex with men. American Journal of Preventive Medicine. 2016;52(1).
    1. Gersh JK, Fiorillo SP, Burghardt L, Nichol AC, Thrun M, Campbell TB. Attitudes and barriers towards pre-exposure prophylaxis (Prep) among high-risk HIV-seronegative men who have sex with men. Journal of AIDS & Clinical Research. 2014;5(8).
    1. Kubicek K, Arauz-Cuadra C, Kipke M. Attitudes and perceptions of biomedical HIV prevention methods: Voices from young men who have sex with men. Archives of Sexual Behavior. 2015;44(2).
    1. Goedel WC, Halkitis PN, Greene RE, Duncan DT. Correlates of awareness of and willingness to use pre-exposure prophylaxis (PrEP) in gay, bisexual, and other men who have sex with men who use geosocial-networking smartphone applications in New York City. AIDS and Behavior. 2016;20(7).
    1. Ayala G, Makofane K, Santos GM, Beck J, Do TD, Hebert P, et al. Access to basic HIV-related services and PrEP acceptability among men who have sex with men worldwide: barriers, facilitators, and implications for combination prevention. Journal of Sexually Transmitted Diseases. 2013;2013:1–11.
    1. Dolezal C, Frasca T, Giguere R, Ibitoye M, Cranston RD, Febo I, Mayer K.H., et al. Awareness of Post-Exposure Prophylaxis (PEP) and Pre-Exposure Prophylaxis. AIDS Education & Prevention. 2015;27(4).
    1. Taylor SW, Mayer K, Elsesser S, Mimiaga M, O'Cleirigh C, Safren S. Optimizing content for pre-exposure prophylaxis (PrEP) counseling for men who have sex with men: Perspectives of PrEP users and high-risk PrEP naïve men. AIDS and Behavior. 2014;18(5).
    1. Koechlin FM, Fonner VA, Dalglish SL, O’Reilly KR, Baggaley R, Grant RM, et al. Values and preferences on the use of oral Pre-exposure Prophylaxis (PrEP) for HIV prevention among multiple populations: A systematic review of the literature. AIDS and Behavior. 2017;21(5).
    1. Arnold T, Brinkley-Rubinstein L, Chan PA, Perez-Brumer A, Bologna ES, Beauchamps L, et al. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi. PLoS One. 2017;12(2).
    1. Parsons J, Rendina H, Whitfield T, Grov C. Familiarity with and preferences for oral and long-acting injectable HIV Pre-exposure Prophylaxis (PrEP) in a national sample of gay and bisexual men in the U.S. AIDS And Behavior. 2016;20(7).
    1. Bauermeister J, Meanley S, Pingel E, Soler J, Harper G. PrEP awareness and perceived barriers among single young men who have sex with men in the United States. Current HIV Research. 2013;11(7).
    1. Jacobs RJ, Caballero J, Ownby RL, Acevedo A, Kane MN. Motivational factors related to medication adherence in Spanish-dominant Hispanics living With HIV. Journal of HIV/AIDS & Social Services. 2015;14(3).
    1. Golub SA, Gamarel KE. The impact of anticipated HIV stigma on delays in HIV testing behaviors: Findings from a community-based sample of men who have sex with men and transgender women in New York City. AIDS Patient Care and STDs. 2013;27(11).
    1. Eaton LA, Driffin DD, Bauermeister J, Smith H, Conway-Washington C. Minimal awareness and stalled uptake of pre-exposure prophylaxis (PrEP) among at risk, HIV-negative, black men who have sex with men. AIDS Patient Care and STDs. 2015;29(8).
    1. Grov C, Whitfield TF, Rendina HJ, Ventuneac A, Parsons JT. Willingness to take PrEP and potential for risk compensation among highly sexually active gay and bisexual men. AIDS and Behavior. 2015;19(12).
    1. Galvan FH, Bogart LM, Klein DJ, Wagner GJ, Chen YT. Medical mistrust as a key mediator in the association between perceived discrimination and adherence to antiretroviral therapy among HIV-positive Latino men. Journal of Behavioral Medicine. 2017:1–10. doi:
    1. Blumenthal J, Jain S, Krakower D, Sun X, Young J, Mayer K, et al. Knowledge is power! Increased provider knowledge scores regarding Pre-exposure Prophylaxis (PrEP) are associated with higher rates of PrEP prescription and future intent to prescribe PrEP. AIDS & Behavior. 2015;19(5).
    1. Chen Y, McFarland W, Raymond H, Snowden J. Pre-exposure Prophylaxis (PrEP) use, seroadaptation, and sexual behavior among men who have sex with men, San Francisco, 2004–2014. AIDS and Behavior. 2016;20(12).
    1. Adams J. Risk: Routledge; 1995.
    1. Graham J. Target risk: Dealing with the danger of death, disease and damage in everyday decisions. Injury Prevention. 1998;4(2).
    1. Spinner CD, Boesecke C, Zink A, Jessen H., Stellbrink HJ, Rockstroh JK, Esser S. HIV Pre-Exposure Prophylaxis (PrEP): a review of current knowledge of oral systemic HIV PrEP in humans. Infection. 2016;44(2).
    1. Calabrese SK, Magnus M, Mayer KH, Krakower DS, Eldahan AI, Hawkins LAG, et al. Putting PrEP into practice: lessons learned from early-adopting US providers’ firsthand experiences providing HIV pre-exposure prophylaxis and associated care. PLoS One. 2016;11(6).
    1. Marcus JL, Hurley LB, Hare CB, Nguyen DP, Phengrasamy T, Silverberg MJ, et al. Preexposure Prophylaxis for HIV prevention in a large integrated health care system: Adherence, renal Safety, and discontinuation. Journal of Acquired Immune Deficiency Syndromes. 2016;73(5).
    1. Mayer KH, Safren SA, Elsesser SA, Psaros C, Tinsley JP, Marzinke M, et al. Optimizing pre-exposure antiretroviral prophylaxis adherence in men who have sex with men: Results of a pilot randomized controlled trial of “Life-Steps for PrEP”. AIDS and Behavior. 2017;21(5).
    1. Taylor SW, Psaros C, Pantalone DW, Tinsley J, Elsesser SA, Mayer KH, et al. “Life-Steps” for PrEP adherence: demonstration of a CBT-based intervention to increase adherence to preexposure prophylaxis (PrEP) medication among sexual-minority men at high risk for HIV acquisition. Cognitive and Behavioral Practice. 2017;24(1).
    1. Molina JM, Capitant C, Spire B, Pialoux G, Chidiac C, Charreau I. On demand PrEP with oral TDF-FTC in MSM: results of the ANRS Ipergay trial. Conference on Retroviruses and Opportunistic infections 2015.
    1. Hojilla JC, Koester KA, Cohen SE, Buchbinder S, Ladzekpo D, Matheson T, et al. Sexual behavior, risk compensation, and HIV prevention strategies among participants in the San Francisco PrEP demonstration project: A qualitative analysis of counseling notes. AIDS and Behavior. 2016;20(7).
    1. Pines HA, Gorbach PM, Weiss RE, Shoptaw S, Landovitz RJ, Javanbakht M, et al. Sexual risk trajectories among MSM in the United States: Implications for pre-exposure prophylaxis delivery. Journal of Acquired Immune Deficiency Syndromes. 1999;65(5).
    1. Elsesser SA, Oldenburg CE, Biello KB, Mimiaga MJ, Safren SA, Egan JE, et al. Seasons of risk: Anticipated behavior on vacation and interest in episodic antiretroviral pre-exposure prophylaxis (PrEP) among a large national sample of U.S. men who have sex with men (MSM). AIDS and Behavior. 2016;20(7).
    1. Pritchard A, Morgan NJ, Sedgley D, Khan E, Jenkins A. Sexuality and holiday choices: Conversations with gay and lesbian tourists. Leisure Studies. 2000;19(4).
    1. Gomez GB, Borquez A, Case KK, Wheelock A, Vassall A, Hankins C. The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies. PLoS One. 2013;10(3).
    1. Drabo EF, Hay JW, Vardavas R, Wagner ZR, Sood N. A cost-effectiveness analysis of preexposure prophylaxis for the prevention of HIV among Los Angeles County men who have sex with men. Clinical Infectious Diseases. 2016;63(11).
    1. Elopre L, Kudroff K, Westfall AO, Overton ET, Mugavero MJ. Brief report: The right people, right places, and right practices: Disparities in PrEP access among African American men, women, and MSM in the deep South. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2017;74(1).
    1. Calabrese SK, Underhill K, Earnshaw VA, Hansen NB, Kershaw TS, Magnus M, et al. Framing HIV pre-exposure prophylaxis (PrEP) for the general public: How inclusive messaging may prevent prejudice from diminishing public support. AIDS and Behavior. 2016;20(7).
    1. Smith DK, Mendoza MC, Stryker JE, Rose CE. PrEP awareness and attitudes in a national survey of primary care clinicians in the United States, 2009–2015. PLoS One. 2016;11(6).
    1. Calabrese SK, Earnshaw VA, Underhill K, Hansen NB, Dovidio JF. The impact of patient race on clinical decisions related to prescribing HIV pre-exposure prophylaxis (PrEP): assumptions about sexual risk compensation and implications for access. AIDS and Behavior. 2014;18(2).
    1. Lelutiu-Weinberger C, Golub SA. Enhancing PrEP access for Black and Latino men who have sex with men. Journal of Acquired Immune Deficiency Syndromes. 2016;73(5).
    1. Underhill K, Morrow KM, Colleran C, Calabrese SK, Operario D, Salovey P, et al. Explaining the efficacy of pre-exposure prophylaxis (PrEP) for HIV prevention: A qualitative study of message framing and messaging preferences among US men who have sex with men. AIDS and Behavior. 2016;20(7).
    1. Collins S, McMahan V, Stekler J. The impact of HIV Pre-exposure Prophylaxis (PrEP) use on the sexual health of men who have sex with men: A qualitative study in Seattle, WA. International Journal of Sexual Health. 2016;29(1).
    1. IBM. IBM SPSS Statistics [Available from: .
    1. Greene GJ, Swann G, Fought AJ, Carballo-Diéguez A, Hope TJ, Kiser PF, et al. Preferences for long-acting Pre-exposure Prophylaxis (PrEP), daily oral PrEP, or condoms for HIV prevention among US men who have sex with men. AIDS and Behavior. 2016;21(5).
    1. Gamble VN. Under the shadow of Tuskegee: African Americans and health care. American Journal of Public Health. 1997;87(11):1773–8.
    1. Westergaard RP, Beach MC, Saha S, Jacobs EA. Racial/Ethnic differences in trust in health care: HIV conspiracy beliefs and vaccine research participation. Journal of General Internal Medicine. 2014;29(1):140–6. doi:
    1. Heller J. Rumors and realities: Making sense of HIV/AIDS conspiracy narratives and contemporary legends. American Journal of Public Health. 2014;105(1):e43–e50.
    1. McLaughlin ML, Hou J, Meng J, Hu C-W, An Z, Park M, et al. Propagation of information about Preexposure Prophylaxis (PrEP) for HIV prevention through Twitter. Health Communication. 2016;31(8):998–1007. doi:
    1. Oldenburg C, Perez-Brumer A, Hatzenbuehler M, Krakower D, Novak D, Mimiaga M, et al. Structural stigma affects access to pre-and post-exposure prophylaxis and HIV risk among men who have sex with men (MSM) in the United States. AIDS research and human retroviruses. 2014;30(S1):A22–A3.
    1. Merchant RC, Corner D, Garza E, Guan W, Mayer KH, Brown L, et al. Preferences for HIV pre-exposure prophylaxis (PrEP) information among men who have sex with men (MSM) at community outreach settings. Journal of Gay & Lesbian Mental Health. 2016;20(1).
    1. Ryan C, Bauman K. Educational Attainment in the United States: 2015. In: U. S. Department of Commerce ESA, editor. Washington, DC: U.S. Census Bureau; 2016, March.
    1. Joint Economic Committee. The economic state of the Latino community in America. Washington, DC: United States Congress; 2015, October.
    1. Jayakumaran JS, Aaron E, Gracely EJ, Schriver E, Szep Z. Knowledge, attitudes, and acceptability of pre-exposure prophylaxis among individuals living with HIV in an urban HIV clinic. PLoS One. 2016;11(2).

Source: PubMed

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