Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials

Hao Zhang, Yan Lu, Meng Liu, Zui Zou, Long Wang, Feng-Ying Xu, Xue-Yin Shi, Hao Zhang, Yan Lu, Meng Liu, Zui Zou, Long Wang, Feng-Ying Xu, Xue-Yin Shi

Abstract

Introduction: The ideal measures to prevent postoperative delirium remain unestablished. We conducted this systematic review and meta-analysis to clarify the significance of potential interventions.

Methods: The PRISMA statement guidelines were followed. Two researchers searched MEDLINE, EMBASE, CINAHL and the Cochrane Library for articles published in English before August 2012. Additional sources included reference lists from reviews and related articles from 'Google Scholar'. Randomized clinical trials (RCTs) on interventions seeking to prevent postoperative delirium in adult patients were included. Data extraction and methodological quality assessment were performed using predefined data fields and scoring system. Meta-analysis was accomplished for studies that used similar strategies. The primary outcome measure was the incidence of postoperative delirium. We further tested whether interventions effective in preventing postoperative delirium shortened the length of hospital stay.

Results: We identified 38 RCTs with interventions ranging from perioperative managements to pharmacological, psychological or multicomponent interventions. Meta-analysis showed dexmedetomidine sedation was associated with less delirium compared to sedation produced by other drugs (two RCTs with 415 patients, pooled risk ratio (RR)=0.39; 95% confidence interval (CI)=0.16 to 0.95). Both typical (three RCTs with 965 patients, RR=0.71; 95% CI=0.54 to 0.93) and atypical antipsychotics (three RCTs with 627 patients, RR=0.36; 95% CI=0.26 to 0.50) decreased delirium occurrence when compared to placebos. Multicomponent interventions (two RCTs with 325 patients, RR=0.71; 95% CI=0.58 to 0.86) were effective in preventing delirium. No difference in the incidences of delirium was found between: neuraxial and general anesthesia (four RCTs with 511 patients, RR=0.99; 95% CI=0.65 to 1.50); epidural and intravenous analgesia (three RCTs with 167 patients, RR=0.93; 95% CI=0.61 to 1.43) or acetylcholinesterase inhibitors and placebo (four RCTs with 242 patients, RR=0.95; 95% CI=0.63 to 1.44). Effective prevention of postoperative delirium did not shorten the length of hospital stay (10 RCTs with 1,636 patients, pooled SMD (standard mean difference)=-0.06; 95% CI=-0.16 to 0.04).

Conclusions: The included studies showed great inconsistencies in definition, incidence, severity and duration of postoperative delirium. Meta-analysis supported dexmedetomidine sedation, multicomponent interventions and antipsychotics were useful in preventing postoperative delirium.

Figures

Figure 1
Figure 1
Flow chart of identification, screening, review and selection of studies. *indicates the group of studies identified for meta-analysis.
Figure 2
Figure 2
Summary relative risks (RRs) for the incidences of postoperative delirium in trials comparing different anesthesia (A), analgesia (B) and postoperative sedation (C) methods.
Figure 3
Figure 3
Summary relative risks (RRs) for the incidences of postoperative delirium in trials testing the role of acetylcholinesterase inhibitors (AchEI) (A) and antipyschotics (B).
Figure 4
Figure 4
Interventions successful in preventing postoperative delirium failed to shorten the length of hospital stay. (A) Summary standard mean differences (SMDs) for the length of hospital stay between interventions with less delirium and interventions with more delirium. (B) Begg's funnel plot with effect measures (SMD) as a function of its standard error (SE) for the length of hospital stay.

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