Choice of Dose Level for a Randomized Clinical Trial of Low-Dose Bevacizumab vs Laser for Type 1 Retinopathy of Prematurity
Raymond T Kraker, David K Wallace, Roy W Beck, Christina T Saunders, Elizabeth Lorenzi, B Michele Melia, Zhuokai Li, Pediatric Eye Disease Investigator Group, Sharon F Freedman, Sasapin G Prakalapakorn, Sarah K Jones, David A Nasrazadani, Ann Martin Cranford, Beth McLendon Arvik, Mary Miller-Bell, Catherine S Sampey, Barbara K Wiernek, Earl R Crouch 3rd, Earl R Crouch Jr, Gaylord G Ventura, James E Dice, Amy K Hutchinson, G Baker Hubbard 3rd, Joshua E Robinson, Judy L Brower, Xi-Juan Chen, James E Rhodes, David L Rogers, Don L Bremer, Richard P Golden, Catherine O Jordan, Mary Lou McGregor, Rachel E Reem, Sara Ann Maletic, Meghan C McMillin, Rachel Tobe Miller, Jill E Bind, Julie A Leary, Regina M Mhaskar, Teresa L Stiltner, Michael B Yang, Eniolami O Dosunmu, Michael E Gray, William W Motley 3rd, Terry L Schwartz, Patricia Cobb, Patricia Hirsch, Melissa Reed, Denise Lagory, Steven Topmiller, David K Coats, Amit R Bhatt, Ann B Demny, Lingkun Kong, Vanessa K Bui, Jennifer L Lynds, Tara P McCartney, Deborah K Vanderveen, Jason S Mantagos, Carolyn Wu, Grace Yoon, Samantha Goldstein, Tamar Winter, Rocco Anzaldi, Charline S Boente, Heather A Smith, Kathyrn M Haider, Elizabeth A Hynes, Melissa Allard, Annette Head, David Morse, R Michael Siatkowski, Janine E Collinge, Kelli J Satnes, Michelle H Blunt, Kaci D Taylor, Mary E Hartnett, David C Dries, Robert O Hoffman, Katie J Farnsworth, Susan Sorenson, Darrell S Austin, Nicole M Boyle, Patricia L Connelly, Courtney L Conner, Danielle L Chandler, Quayleen Donahue, Brooke P Fimbel, Robert J Henderson, Amra Hercinovic, James E Hoepner, Joseph D Kaplon, Gillaine Ortiz, Julianne L Robinson, Kathleen M Stutz, David O Toro, Victoria C Woodard, Rui Wu, Donald F Everett, William F Astle, Eileen E Birch, Angela M Chen, Susan A Cotter, Laura B Enyedi, S Ayse Erzurum, Jonathan M Holmes, Scott R Lambert, Katherine A Lee, Vivian A Manh, Ruth E Manny, Michael X Repka, Jayne L Silver, Katherine K Weise, Lisa C Verderber, Marie Diener-West, John D Baker, Barry R Davis, Dale L Phelps, Stephen W Poff, Richard A Saunders, Lawrence Tychsen, Raymond T Kraker, David K Wallace, Roy W Beck, Christina T Saunders, Elizabeth Lorenzi, B Michele Melia, Zhuokai Li, Pediatric Eye Disease Investigator Group, Sharon F Freedman, Sasapin G Prakalapakorn, Sarah K Jones, David A Nasrazadani, Ann Martin Cranford, Beth McLendon Arvik, Mary Miller-Bell, Catherine S Sampey, Barbara K Wiernek, Earl R Crouch 3rd, Earl R Crouch Jr, Gaylord G Ventura, James E Dice, Amy K Hutchinson, G Baker Hubbard 3rd, Joshua E Robinson, Judy L Brower, Xi-Juan Chen, James E Rhodes, David L Rogers, Don L Bremer, Richard P Golden, Catherine O Jordan, Mary Lou McGregor, Rachel E Reem, Sara Ann Maletic, Meghan C McMillin, Rachel Tobe Miller, Jill E Bind, Julie A Leary, Regina M Mhaskar, Teresa L Stiltner, Michael B Yang, Eniolami O Dosunmu, Michael E Gray, William W Motley 3rd, Terry L Schwartz, Patricia Cobb, Patricia Hirsch, Melissa Reed, Denise Lagory, Steven Topmiller, David K Coats, Amit R Bhatt, Ann B Demny, Lingkun Kong, Vanessa K Bui, Jennifer L Lynds, Tara P McCartney, Deborah K Vanderveen, Jason S Mantagos, Carolyn Wu, Grace Yoon, Samantha Goldstein, Tamar Winter, Rocco Anzaldi, Charline S Boente, Heather A Smith, Kathyrn M Haider, Elizabeth A Hynes, Melissa Allard, Annette Head, David Morse, R Michael Siatkowski, Janine E Collinge, Kelli J Satnes, Michelle H Blunt, Kaci D Taylor, Mary E Hartnett, David C Dries, Robert O Hoffman, Katie J Farnsworth, Susan Sorenson, Darrell S Austin, Nicole M Boyle, Patricia L Connelly, Courtney L Conner, Danielle L Chandler, Quayleen Donahue, Brooke P Fimbel, Robert J Henderson, Amra Hercinovic, James E Hoepner, Joseph D Kaplon, Gillaine Ortiz, Julianne L Robinson, Kathleen M Stutz, David O Toro, Victoria C Woodard, Rui Wu, Donald F Everett, William F Astle, Eileen E Birch, Angela M Chen, Susan A Cotter, Laura B Enyedi, S Ayse Erzurum, Jonathan M Holmes, Scott R Lambert, Katherine A Lee, Vivian A Manh, Ruth E Manny, Michael X Repka, Jayne L Silver, Katherine K Weise, Lisa C Verderber, Marie Diener-West, John D Baker, Barry R Davis, Dale L Phelps, Stephen W Poff, Richard A Saunders, Lawrence Tychsen
Abstract
This study determines which of 8 doses of bevacizumab are effective in treating severe retinopathy of prematurity to carry forward to a large-scale randomized clinical trial.
Conflict of interest statement
Conflict of Interest Disclosures: Dr Kraker reported grants from the National Institutes of Health/National Eye Institute as coordinating center for the Pediatric Eye Disease Investigator Group during the conduct of the study. Drs Wallace and Beck reported grants from the National Eye Institute during the conduct of the study. Dr Saunders reported grants from Jaeb Center of Health Research Foundation during the conduct of the study. Dr Lorenzi reported personal fees from Jaeb Center of Health Research Foundation during the conduct of the study. Dr Melia reported grants from the National Eye Institute to their institution during the conduct of the study and nonfinancial support and grants from Regeneron for clinical trials run by the DRCR Retina Network investigating aflibercept outside the submitted work. No other disclosures were reported.
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Source: PubMed