Changes in lysophospholipids and liver status after weight loss: the RESMENA study

Irene Cantero, Itziar Abete, Josep Maria Del Bas, Antoni Caimari, Lluís Arola, M Angeles Zulet, J Alfredo Martinez, Irene Cantero, Itziar Abete, Josep Maria Del Bas, Antoni Caimari, Lluís Arola, M Angeles Zulet, J Alfredo Martinez

Abstract

Background: Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolism and liver status in obese subjects as well as to provide new evidence regarding the interaction of LP metabolism as a key factor in the onset and management of obesity-related diseases such as liver damage.

Methods: Thirty-three subjects from the RESMENA (Reduction of Metabolic Syndrome in Navarra, NCT01087086) study were selected based on their Fatty Liver Index (FLI). Plasma lipid species (lysophosphatidilcholine: LPC, lysophosphatidilethanolamines: LPE and lysophosphatidylinositols: LPI specifically) were determined by LC-MS, while waist circumference (WC) and other non-invasive liver markers such as, FLI and BAAT scores as well as dietary records, anthropometrical measurements, body composition by DXA and other metabolic determinants were analyzed before and after a six-month hypocaloric nutritional intervention.

Results: Computed Z-scores of total LP (LPC, LPE, and LPI) were significantly decreased after 6-months of following a hypocaloric diet. Specifically, LPC14:0, LPC15:0, LPC16:1, LPC18:4, LPC20:4, showed clear relationships with weight loss. Changes in FLI score, WC and BAAT score revealed associations with general changes in LPC score. Interestingly the BAAT score was statistically associated with the LPC score after adjustment for weight loss.

Conclusion: The lipidomic LPC profile analysis revealed a generalized decrease in circulating lysophospholipids after weight loss. The involvement of particular LP in liver metabolism and obesity merit further attention, as some of these specific non-invasive liver markers were reduced independently of weight loss.

Trial registration: NCT01087086. Registered 15 March 2010, retrospectively registry.

Keywords: Hypocaloric diet; Liver; Lysophospholipids; Metabolic syndrome; Obesity.

Conflict of interest statement

Ethics Committee of the University of Navarra (065/2009).Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Changes in LP scores at baseline and after 6 months
Fig. 2
Fig. 2
Linear regression plots between changes in LPC score with FLI, BAAT and waist circumference

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