Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Włodzimierz Luczyński, Wojciech Fendler, Anna Ramatowska, Agnieszka Szypowska, Agnieszka Szadkowska, Wojciech Młynarski, Miron Chumiecki, Przemysława Jarosz-Chobot, Joanna Chrzanowska, Anna Noczyńska, Agnieszka Brandt, Małgorzata Myśliwiec, Barbara Głowińska-Olszewska, Paweł Bernatowicz, Oksana Kowalczuk, Artur Bossowski, Włodzimierz Luczyński, Wojciech Fendler, Anna Ramatowska, Agnieszka Szypowska, Agnieszka Szadkowska, Wojciech Młynarski, Miron Chumiecki, Przemysława Jarosz-Chobot, Joanna Chrzanowska, Anna Noczyńska, Agnieszka Brandt, Małgorzata Myśliwiec, Barbara Głowińska-Olszewska, Paweł Bernatowicz, Oksana Kowalczuk, Artur Bossowski

Abstract

The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4-18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).

Figures

Figure 1
Figure 1
The influence of tested polymorphic variants on standardized BMI (BMI-SDS) in children with type 1 diabetes. D: difference of means, 95% CI: 95% confidence interval, and WT: wild-type.

References

    1. Chrzanowska M, Koziel S, Ulijaszek SJ. Changes in BMI and the prevalence of overweight and obesity in children and adolescents in Cracow, Poland, 1971–2000. Economics & Human Biology. 2007;5(3):370–378.
    1. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–894.
    1. Cecil J, Dalton M, Finlayson G, Blundell J, Hetherington M, Palmer C. Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms. International Review of Psychiatry. 2012;24(3):200–210.
    1. Malzahn D, Müller-Nurasyid M, Heid IM, Wichmann HE, The KORA Study Group6, Bickeböller H. Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. European Journal of Human Genetics. 2014
    1. Steigleder-Schweiger C, Rami-Merhar B, Waldhör T, et al. Prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes in Austria. European Journal of Pediatrics. 2012;171(8):1193–1202.
    1. Krishnan S, Fields DA, Copeland KC, Blackett PR, Anderson MP, Gardner AW. Sex differences in cardiovascular disease risk in adolescents with type 1 diabetes. Gender Medicine. 2012;9(4):251–258.
    1. Mortensen HB, Hougaard P, Swift P, et al. New definition for the partial remission period in children and adolescents with type 1 diabetes. Diabetes Care. 2009;32(8):1384–1390.
    1. Kułaga Z, Litwin M, Tkaczyk M, et al. Polish 2010 growth references for school-aged children and adolescents. European Journal of Pediatrics. 2011;170(5):599–609.
    1. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet. 1986;1(8476):307–310.
    1. Pyrzak B, Wisniewska A, Majcher A, Tysarowski A, Demkow U. Relation of fat-mass and obesity-associated gene polymorphism to fat mass content and body mass index in obese children. Advances in Experimental Medicine and Biology. 2013;756:255–262.
    1. Luczynski W, Zalewski G, Bossowski A. The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in polish children. Journal of Physiology and Pharmacology. 2012;63(3):241–248.
    1. Field SF, Howson JMM, Walker NM, Dunger DB, Todd JA. Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls. Diabetologia. 2007;50(10):2218–2220.
    1. Winkler C, Raab J, Grallert H, Ziegler A. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. PloS ONE. 2012;7(4)e35410
    1. Gu HF, Alvarsson A, Brismar K. The common FTO genetic polymorphism rs9939609 is associated with increased BMI in type 1 diabetes but not with diabetic nephropathy. Biomarker Insights. 2010;5:29–32.
    1. Zhao J, Bradfield JP, Li M, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity. 2009;17(12):2254–2257.
    1. Schwab KO, Doerfer J, Marg W, Schober E, Holl RW. Characterization of 33 488 children and adolescents with type 1 diabetes based on the gender-specific increase of cardiovascular risk factors. Pediatric Diabetes. 2010;11(5):357–363.
    1. Nansel TR, Tse J, Haynie DL, Mehta SN, Laffel LMB. Disordered eating behaviors are associated with poorer diet quality in adolescents with type 1 diabetes. Journal of the Academy of Nutrition and Dietetics. 2012;112(11):1810–1814.
    1. Sands ALP, Higgins LA, Mehta SN, Nansel TR, Lipsky LM, Laffel LMB. Associations of youth and parent weight status with reported versus predicted daily energy intake and hemoglobin A1c in youth with type 1 diabetes mellitus. Journal of Diabetes Science and Technology. 2013;7(1):263–270.

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