Long-lasting neural and behavioral effects of iron deficiency in infancy
Betsy Lozoff, John Beard, James Connor, Felt Barbara, Michael Georgieff, Timothy Schallert, Betsy Lozoff, John Beard, James Connor, Felt Barbara, Michael Georgieff, Timothy Schallert
Abstract
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.
Source: PubMed