Effectiveness of Working Memory Training among Subjects Currently on Sick Leave Due to Complex Symptoms

Julie K Aasvik, Astrid Woodhouse, Tore C Stiles, Henrik B Jacobsen, Tormod Landmark, Mari Glette, Petter C Borchgrevink, Nils I Landrø, Julie K Aasvik, Astrid Woodhouse, Tore C Stiles, Henrik B Jacobsen, Tormod Landmark, Mari Glette, Petter C Borchgrevink, Nils I Landrø

Abstract

Introduction: The current study examined if adaptive working memory training (Cogmed QM) has the potential to improve inhibitory control, working memory capacity, and perceptions of memory functioning in a group of patients currently on sick leave due to symptoms of pain, insomnia, fatigue, depression and anxiety. Participants who were referred to a vocational rehabilitation center volunteered to take part in the study. Methods: Participants were randomly assigned to either a training condition (N = 25) or a control condition (N = 29). Participants in the training condition received working memory training in addition to the clinical intervention offered as part of the rehabilitation program, while participants in the control condition received treatment as usual i.e., the rehabilitation program only. Inhibitory control was measured by The Stop Signal Task, working memory was assessed by the Spatial Working Memory Test, while perceptions of memory functioning were assessed by The Everyday Memory Questionnaire-Revised. Results: Participants in the training group showed a significant improvement on the post-tests of inhibitory control when compared with the comparison group (p = 0.025). The groups did not differ on the post-tests of working memory. Both groups reported less memory problems at post-testing, but there was no sizeable difference between the two groups. Conclusions: Results indicate that working memory training does not improve general working memory capacity per se. Nor does it seem to give any added effects in terms of targeting and improving self-perceived memory functioning. Results do, however, provide evidence to suggest that inhibitory control is accessible and susceptible to modification by adaptive working memory training.

Keywords: adaptive working memory training; complex symptoms; inhibitory control; self-perceived memory functioning; spatial working memory.

Figures

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Figure 1
Consort flow chart.

References

    1. Aasvik J., Woodhouse A., Jacobsen H. B., Borchgrevink P. C., Stiles T., Landrø N. I. (2015). Subjective memory complaints among patients on sick leave are associated with symptoms of fatigue and anxiety. Front. Psychol. 6:1338. 10.3389/fpsyg.2015.01338
    1. Alloway T. P., Alloway R. G. (2010). Investigating the predictive roles of Working memory and IQ in academic attainment. J. Exp. Child Psychol. 106, 20–29. 10.1016/j.jecp.2009.11.003
    1. Alloway T. P., Bibile V., Lau G. (2013). Computerized working memory training: can it lead to gain in skills in students. Comput. Human Behav. 29, 632–638. 10.1016/j.chb.2012.10.023
    1. Anguera J. A., Boccanfuso J., Rintoul J. L., Al-Hashimi O., Faraji F., Janowich J., et al. . (2013). Video game training enhances cognitive control in older adults. Nature 501, 97–101. 10.1038/nature12486
    1. Au J., Sheehan E., Tsai N., Duncan G. J., Buschkuehl M., Jaeggi S. M. (2015). Improving fluid intelligence with training on working memory: a meta-analysis. Psychon. Bull. Rev. 22, 366–377. 10.3758/s13423-014-0699-x
    1. Bastien C. H., Valliéres A., Morin C. M. (2001). Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Med. 2, 297–300. 10.1016/S1389-9457(00)00065-4
    1. Berkman E. T., Kahn L. E., Merchant J. S. (2014). Training induced changes in inhibitory control network activity. J. Neurosci. 34, 149–157. 10.1523/JNEUROSCI.3564-13.2014
    1. Bjelland J., Dahl A. A., Haug T. T., Neckelmann D. (2001). The validity of the hospital anxiety and depression scale an updated literature review. J. Psychosom. Res. 52, 69–77. 10.1016/S0022-3999(01)00296-3
    1. Brehmer Y., Westerberg H., Bäckmann L. (2012). Working-Memory training in younger and older adults: training gains, transfer and maintenance. Front. Hum. Neurosci. 6:63. 10.3389/fnhum.2012.00063
    1. Broadbent D. E., Cooper P. F., Fitzgerald P., Parkes K. R. (1982). The cognitive failure questionnaire (CFQ) and its correlates. (1982). Br. J.Clin. Psychol. 21, 1–16. 10.1111/j.2044-8260.1982.tb01421.x
    1. Chalder T., Berelowitz G., Pawlikovska T., Watts L., Wessely S., Wright D., et al. . (1993). Development of a fatigue scale. J. Psychosom. Res. 37, 147–153. 10.1016/0022-3999(93)90081-P
    1. Chein J. M., Morrison A. B. (2010). Expanding the mind's workspace: training and transfer effects with a complex working memory span task. Psychon. Bull. Rev. 17, 193–199. 10.3758/PBR.17.2.193
    1. Christopher G., MacDonald J. (2005). The impact of clinical depression on working memory. Cogn. Neuropsychiatry 10, 379–399. 10.1080/13546800444000128
    1. Cleeland C. S., Ryan K. M. (1994). Pain assessment: global use of the brief pain inventory. Ann. Acad. Singapore 23, 129–138.
    1. Constant E. L., Adam S., Gillain B., Lambert M., Masquelier E., Seron X. (2011). Cognitive deficits in patients with chronic fatigue syndrome compared to those with major depressive disorder and healthy controls. Clin. Neurol. Neurosurg. 113, 295–302. 10.1016/j.clineuro.2010.12.002
    1. Dahlin K. I. E. (2011). Effects of working memory training on reading in children with special needs. Read. Writ. 24, 479–491. 10.1007/s11145-010-9238-y
    1. Dalley J. W., Everitt B. J., Robbins T. W. (2011). Impulsivity, compulsivity and top-down cognitive control. Neuron 69, 680–694. 10.1016/j.neuron.2011.01.020
    1. Derakshan N., Ansari T. L., Hansard M., Shoker L., Eysenck M. W. (2009). Anxiety, inhibition efficiency and effectiveness: an investigation using the antisaccade task. Exp. Psychol. 56, 48–55. 10.1027/1618-3169.56.1.48
    1. Derousné C., Lacomblez L., Thibault S., Leponcin M. (1999). Memory complaints in young and elderly subjects. Int. J. Geriatr. Psychiatry 14, 291–301. 10.1002/(SICI)1099-1166(199904)14:4<291::AID-GPS902>;2-7
    1. Fimland M. S., Vasseljen O., Gismervik S., Rise M. B., Halsteinli V., Jacobsen H. B., et al. . (2014). Occupational rehabilitation programs for musculoskeletal pain and common mental health disorders: study protocol of a randomized controlled trial. BMC Public Health 14:368. 10.1186/1471-2458-14-368
    1. Folkmann S., Lazarus R. S., Dunkel-Schetter C., Delongis A., Gruen R. J. (1986). Dynamics of a stressful encounter: cognitive appraisal, coping and encounter outcomes. J. Pers. Soc. Psychol. 50, 992–1003. 10.1037/0022-3514.50.5.992
    1. Fortier-Brochu E., Beaulieu-Bonneau S., Ivers H., Morin C. M. (2012). Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med. Rev. 16, 83–94. 10.1016/j.smrv.2011.03.008
    1. Glass J., Park D. C., Minear M., Crofford L. J. (2005). Memory belief and function in fibromyalgia patients. J. Psychosom. Res. 58, 263–269. 10.1016/j.jpsychores.2004.09.004
    1. Grace G. M., Nielson W. R., Hopkins M., Berg M. A. (1999). Concentration and memory deficits in patients with fibromyalgia syndrome. J. Clin. Exp. Neuropsychol. 21, 477–487. 10.1076/jcen.21.4.477.876
    1. Hayes S. C., Strosahl K. D., Wilson K. G. (2003). Acceptance and Commitment Therapy: An Experimental Approach to Behavioral Change. New York, NY: The Guilford press.
    1. Henderson M., Glozier N., Elliott K. H. (2005). Long term sickness absence: is caused by common conditions and needs managing. Br. Med. J. 330, 802–803. 10.1136/bmj.330.7495.802
    1. Jacobsen H. B., Aasvik J. K., Landro N. I., Borchgrevink P. C., Stiles T. C. (2016). Metacognitions are associated with subjective memory problems in patients with chronic fatigue. Front. Psychol. 7:729 10.3389/fpsyg.2016.00729
    1. Jaeggi S. M., Buschkuehl M., Jonides J., Perrig W. J. (2008). Improving fluid intelligence with training on working memory. Proc. Natl. Acad. Sci.U.S.A 105, 6829–6833. 10.1073/pnas.0801268105
    1. Joormann J. (2010). Cognitive inhibition and emotion regulation in depression. Curr. Dir. Psychol. Sci. 19, 161–166. 10.1177/0963721410370293
    1. Joormann J., D'Avanzato C. (2010). Emotion regulation in depression: examining the role of cognitive processes. Cogn. Emot. 24, 913–939. 10.1080/02699931003784939
    1. Kane M. J., Engle R. W. (2000). Working-memory capacity, proactive interference, and divided attention: limits on long–term memory retrieval. J. Exp. Psychol. Learn. Mem. Cogn. 26, 336–358. 10.1037/0278-7393.26.2.336
    1. Klepstad P., Loge J. H., Borchgrevink P. C., Mendoza T. R., Cleeland C. S., Kaasa S. (2002). The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients. J. Pain Symptom Manage. 24, 517–525. 10.1016/S0885-3924(02)00526-2
    1. Klingberg T. (2010). Training and plasticity of working memory. Trends Cogn. Sci. 14, 317–324. 10.1016/j.tics.2010.05.002
    1. Klingberg T., Fernell E., Olesen P. J., Johnson M., Gustafsson P., Dahlström K., et al. . (2005). Computerized training of working memory in children with ADHD – A randomized, controlled trial. Child Adolesc. Psychiatry 44, 177–186. 10.1097/00004583-200502000-00010
    1. Klingberg T., Forssberg H., Westerberg H. (2002).Training of working memory in children with ADHD. J. Clin. Exp. Psychol. 24, 781–791. 10.1076/jcen.24.6.781.8395
    1. Kronholm E., Sallinen M., Suutama T., Sulkava R., Era P., Partonen T. (2009). Self-reported sleep duration and cognitive functioning in the general population. J. Sleep Res. 18, 436–446. 10.1111/j.1365-2869.2009.00765.
    1. Landrø N. I., Fors E. A., Våpenstad L. L., Holthe Ø., Stiles T., Borchgrevink P. C. (2013). The extent of neurocognitive dysfunction in a multidisciplinary pain center population. Is there a relation between reported and tested neuropsychological functioning? Pain 154, 972–977. 10.1016/j.pain.2013.01.013
    1. Logan G. D., Cowan D. B. (1984). On the ability to inhibit thought and action: a theory of an act of control. Psychol. Rev. 91, 295–327. 10.1037/0033-295X.91.3.295
    1. Logan G. D., Cowan D. B., Davis K. A. (1984). On the ability to inhibit simple and choice reaction time responses- a model and a method. J. Exp. Psychol. Hum. Percept. Perform. 10, 276–291. 10.1037/0096-1523.10.2.276
    1. Loge J. H., Ekeberg O., Kaasa S. (1998). Fatigue in the Norwegian population: normative data and associations. J. Psychosom. Res. 45, 53–65. 10.1016/S0022-3999(97)00291-2
    1. Melby-Lervåg M., Hulme C. (2013). Is working memory training effective? A meta-analytic review. Dev. Psychol. 49, 270–291. 10.1037/a0028228
    1. Miyake A., Friedman N. P. (2012). The nature and organization of individual differences in executive functions: four general conclusions. Curr. Dir. Psychol. Sci. 21, 8–14. 10.1177/0963721411429458
    1. Miyake A., Friedman N. P., Emerson M. J., Witzki A. H., Howerter A. (2000). The unity and diversity of executive functions and their contributions to complex frontal lobe tasks: a latent variable analysis. Cogn. Psychol. 41, 49–100. 10.1006/cogp.1999.0734
    1. Morin C. M., Belleville G., Bélager L., Ivers H. (2011). The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 34, 601–608.
    1. Morrison A. B., Chein J. M. (2011). Does working memory training work? The promise and challenges of enhancing cognition by training working memory. Psychon. Bull. Rev. 18, 46–60. 10.3758/s13423-010-0034-0
    1. Mowla A., Ashkani H., Ganizadeh A., Dehbozorgi G. R., Sabayan B., Chohedri A. B. (2008). Do memory complaints represent impaired memory performance in patients with major depressive disorder? Depress. Anxiety, 25, E92–E96. 10.1002/da.20343
    1. Ochsner K. N., Gross J. J. (2005). The cognitive control of emotion. Trends Cogn. Sci. 9, 242–249. 10.1016/j.tics.2005.03.010
    1. Olesen P. J., Westerberg H., Klingberg T. (2004). Increased prefrontal and parietal activity after training on working memory. Nat. Neurosci. 7, 75–79. 10.1038/nn1165
    1. Olssøn J., Mykletun A., Dahl A. (2005). The hospital anxiety and depression rating scale: a cross sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry 5:46. 10.1186/1471-244X-5-46
    1. Oosterman J. M., Dijkerman H. C., Kessels R. P. C., Scherder E. J. A. (2010). A unique association between cognitive inhibition and pain sensitivity in healthy participants. Eur. J. Pain 14, 1046–1050. 10.1016/j.ejpain.2010.04.004
    1. Owen A. M., Downes J. J., Sahakian B. J., Polkey C. E., Robbins T. W. (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 1021–1034. 10.1016/0028-3932(90)90137-D
    1. Owen A. M., Hampshire A., Grahn J. A., Stenton R., Dajani S., Burns A. S., et al. . (2010). Putting brain training to the test. Nature 465, 775–778. 10.1038/nature09042
    1. Redick T. S., Shipstead Z., Harrison T. L., Hicks K. L., Fried D. E., Hambrick D. Z., et al. . (2012). No evidence of intelligence improvement after working memory training: a randomized, placebo-controlled study. J. Exp. Psychol. 142, 359–379. 10.1037/a0029082
    1. Royle J., Lincoln N. B. (2008). The everyday memory questionnaire-revised: development of a 13 item scale. Disabil. Rehabil. 30, 114–121. 10.1080/09638280701223876
    1. Sahakian B. J., Owen A. M. (1992). Computerized assessment in neuropsychiatry using CANTAB. J. R. Soc. Med. 85, 399–402.
    1. Salminen T., Strobach T., Schubert T. (2012). On the impacts of working memory training on executive functioning. Front. Hum. Neurosci. 6:166. 10.3389/fnhum.2012.00166
    1. Shipstead Z., Redick T. S., Engle R. W. (2012). Is working memory training effective? Psychol. Bull. 138, 628–654. 10.1037/a0027473
    1. Siegle G. J., Ghinassi F., Thase M. E. (2007). Neurobehavioral therapies in the 21st century: summary of an emerging field of and an extended example of cognitive control training for depression. Cogn. Therapy Res. 31, 235–262. 10.1007/s10608-006-9118-6
    1. Stenfors C. U. D., Marklund P., Hanson L. L. M., Theorell T., Nilsson L. G. (2013). Subjective cognitive complaints and the role of executive cognitive functioning in the working population: a case control study. PLoS ONE 8:e83351. 10.1371/journal.pone.0083351
    1. Suhr J. A. (2003). Neuropsychological impairment in fibromyalgia: relation to depression, fatigue and pain. J. Psychosom. Res. 4, 321–329. 10.1016/S0022-3999(02)00628-1
    1. Sunderland A., Harris J. E., Baddely A. D. (1983). Do laboratory tests predict everyday memory? A neuropsychological study. J. Verbal Learn. Verbal Behav. 22, 727–738. 10.1093/brain/awu207
    1. Tesio V., Torta D. M. E., Colonna F., Leombruni P., Gihiggia A., Fusaro E., et al. . (2015). Are fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence. Arthritis Care Res. 67, 143–150. 10.1002/acr.22403
    1. Thorell L. B., Lindquist S., Bergman S., Bohlin G., Klingberg T. (2009). Training and transfer effects of executive functions in preschool children. Dev. Sci. 12, 106–113. 10.1111/j.1467-7687.2008.00745.x
    1. Van der Molen M. J., Van Luit J. E. H., Van der Molen M. W., Klugist I., Jongmans M. J. (2010). Effectiveness of a computerized working memory training in adolescents with mild to borderline intellectual disabilities. J. Intell. Disabil. Res. 54, 433–447. 10.1111/j.1365-2788.2010.01285.x
    1. Waris O., Soveri A., Laine M. (2015). Transfer after working memory updating training. PLoS ONE 10:e0138734. 10.1371/journal.pone.0138734
    1. Wechsler D. (1997). Wechsler Adult Intelligence Scale–3rd Edn. San Antonio, TX: The Psychological Corporation.
    1. Westerberg H., Jacobaeus H., Hirvikoski T., Clevberger P., Ostensson M. L., Bartfai A., et al. . (2007). Computerized working memory training after stroke – a pilot study. Brain Injury 21, 21–29. 10.1080/02699050601148726
    1. Williams D. A., Clauw D. J., Glass J. M. (2011). Perceived cognitive dysfunction in fibromyalgia syndrome. J. Musculoskelet. Pain 19, 66–76. 10.3109/10582452.2011.558989
    1. Zigmond A. S., Snaith R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatr. Scand. 67, 361–370. 10.1111/j.1600-0447.1983.tb09716.x
    1. Zinke K., Zeintl M., Eschen A Herzog, C., Kliegel M. (2012). Potentials and limits of plasticity induced by working memory training in old age. Gerontology 58, 79–87. 10.1159/000324240

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