Effects of two lipid lowering therapies on immune responses in hyperlipidemic subjects
Flavio Tocci Moreira, Silvia Cristina Ramos, Andrea Moreira Monteiro, Tatiana Helfenstein, Magnus Gidlund, Nagila Raquel Teixeira Damasceno, Antonio Martins Figueiredo Neto, Maria Cristina Izar, Francisco Antonio Helfenstein Fonseca, Flavio Tocci Moreira, Silvia Cristina Ramos, Andrea Moreira Monteiro, Tatiana Helfenstein, Magnus Gidlund, Nagila Raquel Teixeira Damasceno, Antonio Martins Figueiredo Neto, Maria Cristina Izar, Francisco Antonio Helfenstein Fonseca
Abstract
Aims: To compare the effects of two of the most effective lipid-lowering therapies with similar LDL-cholesterol reduction capacity on the innate and adaptive immune responses through the evaluation of autoantibodies anti-oxidized LDL (anti-oxLDL Abs) and electronegative LDL [LDL(-)] levels.
Main methods: We performed a prospective, randomized, open label study, with parallel arms and blinded endpoints. One hundred and twelve subjects completed the study protocol and received rosuvastatin 40 mg or ezetimibe/simvastatin 10/40 mg for 12 weeks. Lipids, apolipoproteins, LDL(-), and anti-oxLDL Abs (IgG) were assayed at baseline and end of study.
Key findings: Main clinical and laboratory characteristics were comparable at baseline. Lipid modifications were similar in both treatment arms, however, a significant raise in anti-oxLDL Abs levels was observed in subjects treated with rosuvastatin (p=0.026 vs. baseline), but not in those receiving simvastatin/ezetimibe. (p=0.233 vs. baseline), thus suggesting modulation of adaptive immunity by a potent statin. Titers of LDL(-) were not modified by the treatments.
Significance: Considering atherosclerosis as an immune disease, this study adds new information, showing that under similar LDL-cholesterol reduction, the choice of lipid-lowering therapy can differently modulate adaptive immune responses.
Keywords: Dyslipidemia; Electronegative low-density lipoprotein; Ezetimibe; Oxidized LDL; Statins.
Copyright © 2014 Elsevier Inc. All rights reserved.
Source: PubMed