Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa

Eduardo Vieira Couto, Carlos Roberto Ballin, Claudia Paraguaçu Pupo Sampaio, Carlos Augusto Seije Maeda, Carlos Henrique Ballin, Camila Soares Dassi, Lilian Yukari Miura, Eduardo Vieira Couto, Carlos Roberto Ballin, Claudia Paraguaçu Pupo Sampaio, Carlos Augusto Seije Maeda, Carlos Henrique Ballin, Camila Soares Dassi, Lilian Yukari Miura

Abstract

Introduction: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing.

Objectives: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds.

Methods: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated.

Results: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group.

Conclusion: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.

Keywords: Angiogenesis-inducing agents; Cicatrização; Indutores da angiogênese; Tonsilectomia; Tonsillectomy; Wound healing.

Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

Figures

Figure 1
Figure 1
Surgical wound induction.
Figure 2
Figure 2
Wound removal on D7.
Figure 3
Figure 3
Mask used for the reading of Picrosirius staining.
Figure 4
Figure 4
Slide showing Picrosirius staining of integra.
Figure 5
Figure 5
Finished slides and paraffin after punch was performed.
Figure 6
Figure 6
Mask used for the reading of CD34 marker.
Figure 7
Figure 7
Slide showing CD34 marker of integra.

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