Concomitant fibromyalgia complicating chronic inflammatory arthritis: a systematic review and meta-analysis

Stephen J Duffield, Natasha Miller, Sizheng Zhao, Nicola J Goodson, Stephen J Duffield, Natasha Miller, Sizheng Zhao, Nicola J Goodson

Abstract

Objectives: This systematic review and meta-analysis will describe the prevalence of concomitant FM in adults with inflammatory arthritis and quantify the impact of FM on DAS.

Methods: Cochrane library, MEDLINE, Psychinfo, PubMed, Scopus and Web of Science were searched using key terms and predefined exclusion criteria. As appropriate, proportional and pairwise meta-analysis methods were used to pool results.

Results: Forty articles were identified. In RA the prevalence of FM ranged from 4.9 to 52.4% (21% pooled). In axSpA the range was 4.11-25.2% (13% pooled in AS only). In PsA the range was 9.6-27.2% (18% pooled). The presence of concomitant FM was related to higher DAS in patients with RA and AS (DAS28 mean difference 1.24, 95% CI: 1.10, 1.37 in RA; BASDAI mean difference 2.22, 95% CI: 1.86, 2.58 in AS). Concomitant FM was also associated with higher DAS in existing PsA studies. Self-reported, rather than objective, components of DAS appear to be raised in the presence of FM (e.g. tender joint count and Visual Analogue Scale (VAS) pain scores).

Conclusion: FM is common in RA, AxSpA and PsA. Comorbid FM appears to amplify DAS and could therefore influence management of these rheumatic conditions.

Figures

F ig . 1
Fig. 1
Flowchart showing selection of suitable articles
F ig . 2
Fig. 2
Fixed-effects meta-analysis of DAS28 in RA vs RA with comorbid FM df: degrees of freedom; iv: inverse variance.
F ig . 3
Fig. 3
Fixed-effects meta-analysis of BASDAI in AS vs AS with comorbid FM df: degrees of freedom; iv: inverse variance.

References

    1. Raspe H, Croft P.. Fibromyalgia. Baillieres Clin Rheumatol 1995;9:599–614.
    1. Borchers AT, Gershwin ME.. Fibromyalgia: a critical and comprehensive review. Clin Rev Allergy Immunol 2015;49:100–51.
    1. Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol 2005;32:6–21.
    1. Neumann L, Buskila D.. Epidemiology of fibromyalgia. Curr Pain Headache Rep 2003;7:362–8.
    1. White KP, Speechley M, Harth M, Ostbye T.. The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario. J Rheumatol 1999;26:1570–6.
    1. Branco JC, Bannwarth B, Failde I. et al. Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum 2010;39:448–53.
    1. Jones GT, Atzeni F, Beasley M. et al. The prevalence of fibromyalgia in the general population: a comparison of the American College of Rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol 2015;67:568–75.
    1. Wolfe F, Smythe HA, Yunus MB. et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160–72.
    1. Wolfe F. Fibromyalgianess. Arthritis Rheum 2009;61:715–6.
    1. Torrente-Segarra V, Carbonell-Abello J, Castro-Oreiro S, Manresa Dominguez JM.. Association between fibromyalgia and psychiatric disorders in systemic lupus erythematosus. Clin Exp Rheumatol 2010;28 (6 Suppl 63):S22–6.
    1. Haliloglu S, Carlioglu A, Akdeniz D, Karaaslan Y, Kosar A.. Fibromyalgia in patients with other rheumatic diseases: prevalence and relationship with disease activity. Rheumatol Int 2014;34:1275–80.
    1. Smolen JS, Landewé R, Breedveld FC. et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 2014;73:492–509.
    1. Almodovar R, Carmona L, Zarco P. et al. Fibromyalgia in patients with ankylosing spondylitis: prevalence and utility of the measures of activity, function and radiological damage. Clin Exp Rheumatol 2010;28 (6 Suppl 63):S33–9.
    1. Joharatnam N, McWilliams DF, Wilson D. et al. A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis. Arthritis Res Ther 2015;17:11.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG.. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. PLoS Med 2009;6:e1000097.
    1. Wells GA, Shea B, O’Connell D. et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Hosp Res Inst 2013;3:1–4.
    1. Abbasi L, Haidri FR.. Fibromyalgia complicating disease management in rheumatoid arthritis. J Coll Physicians Surg Pak 2014;24:424–7.
    1. Ahmad J, Blumen H, Tagoe CE.. Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis. Rheumatol Int 2015;35:1415–21.
    1. Amity CL, Schlenk EA, Gold KN. et al. Agreement of physicians and nurses performing tender and swollen joint counts in rheumatoid arthritis. J Clin Rheumatol 2016;22:30–4.
    1. Buyukbese M, Pamuk O, Yurekli O, Yesil N.. Effect of fibromyalgia on bone mineral density in patients with fibromylagia and rheumatoid arthritis. J Postgrad Med 2013;59:106.
    1. Da Silva Chakr RM, Brenol JCT, Behar M. et al. Is ultrasound a better target than clinical disease activity scores in Rheumatoid Arthritis with fibromyalgia? A case-control study. PLoS One 2015;10:e0118620.
    1. Da Silva Chakr RM, Brenol C, Ranzolin A. et al. Rheumatoid arthritis seems to have DMARD treatment decision influenced by fibromyalgia. Rev Bras Reumatol 2017;57:403–411.
    1. Christensen AW, Rifbjerg-Madsen S, Christensen R. et al. Non-nociceptive pain in rheumatoid arthritis is frequent and affects disease activity estimation: cross-sectional data from the FRAME study. Scand J Rheumatol 2016;45:461–9.
    1. Coury F, Rossat A, Tebib A. et al. Rheumatoid arthritis and fibromyalgia: a frequent unrelated association complicating disease management. J Rheumatol 2009;36:58–62.
    1. Dhir V, Lawrence A, Aggarwal A, Misra R.. Fibromyalgia is common and adversely affects pain and fatigue perception in North Indian patients with rheumatoid arthritis. J Rheumatol 2009;36:2443–9.
    1. El-Rabbat MS, Mahmoud NK, Gheita TA.. Clinical significance of fibromyalgia syndrome in different rheumatic diseases: relation to disease activity and quality of life. Reumatol Clin 2017; doi: 10.1016/j.reuma.2017.02.008.
    1. Fan A, Pereira B, Tournadre A. et al. Frequency of concomitant fibromyalgia in rheumatic diseases: monocentric study of 691 patients. Semin Arthritis Rheum 2017;47:129–32.
    1. Gheita TA, Sayed S, Gheita HA, Kenawy SA.. Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome. Int J Rheum Dis 2016;19:294–9.
    1. Ghib LJ, Tamas M-M, Damian LO. et al. The role of ultrasonography in assessing disease activity in patients with rheumatoid arthritis and associated fibromyalgia. Med Ultrason 2015;17:339–44.
    1. Gist AC, Guymer EK, Eades LE, Leech M, Littlejohn GO.. Fibromyalgia remains a significant burden in rheumatoid arthritis patients in Australia. Int J Rheum Dis 2018;21:639–46
    1. Karpouzas GA, Dolatabadi S, Moran R. et al. Correlates and predictors of disability in vulnerable US Hispanics with rheumatoid arthritis. Arthritis Care Res 2012;64:1274–81.
    1. Kapoor SR, Hider SL, Brownfield A, Mattey DL, Packham JC.. Fibromyalgia in patients with rheumatoid arthritis: driven by depression or joint damage? Clin Exp Rheumatol 2011;29 (6 Suppl 69):S88–91.
    1. Lage-Hansen PR, Chrysidis S, Lage-Hansen M. et al. Concomitant fibromyalgia in rheumatoid arthritis is associated with the more frequent use of biological therapy: a cross-sectional study. Scand J Rheumatol 2016;45:45–8.
    1. Mian AN, Chaabo K, Wajed J. et al. Rheumatoid arthritis patients with fibromyalgic clinical features have significantly less synovitis as defined by power Doppler ultrasound. BMC Musculoskelet Disord 2016;17:404.
    1. Nawito Z, Rady HM, Maged LA.. The impact of fibromyalgia on disease assessment in rheumatoid arthritis patients. Egypt Rheumatol 2013;35:115–9.
    1. Pollard LC, Kingsley GH, Choy EH, Scott DL.. Fibromyalgic rheumatoid arthritis and disease assessment. Rheumatology 2010;49:924–8.
    1. Ranzolin A, Brenol JC, Bredemeier M. et al. Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis. Arthritis Rheum Arthritis Care Res 2009;61:794–801.
    1. Ton E, Bakker MF, Verstappen SMM. et al. Look beyond the disease activity score of 28 joints (DAS28): tender points influence the DAS28 in patients with rheumatoid arthritis. J Rheumatol 2012;39:22–7.
    1. Urrows S, Affleck G, Tennen H, Higgins P.. Unique clinical and psychological correlates of fibromyalgia tender points and joint tenderness in rheumatoid arthritis. Arthritis Rheum 1994;37:1513–20.
    1. Roig Vilaseca D, Hoces Otero C.. Effect of the coexistence of fibromyalgia in the DAS28 index in women with rheumatoid arthritis. Reumatol Clinica Engl Ed 2008;4:96–9.
    1. Zammurrad S, Aziz W, Farooqi A.. Disease activity score in rheumatoid arthritis with or without secondary fibromyalgia. J Coll Physicians Surg Pakistan 2013;23:413–7.
    1. Di Carlo M, Becciolini A, Lato V. et al. The 12-item Psoriatic Arthritis Impact of Disease Questionnaire: construct validity, reliability, and interpretability in a clinical setting. J Rheumatol 2017;44:279–85.
    1. Graceffa D, Maiani E, Sperduti I, Ceralli F, Bonifati C.. Clinical remission of psoriatic arthritis in patients receiving continuous biological therapies for 1 year: the experience of an outpatient dermatological clinic for psoriasis. Clin Exp Dermatol 2015;40:136–41.
    1. Husted JA, Tom BDM, Farewell VT, Gladman DD.. Longitudinal analysis of fatigue in psoriatic arthritis. J Rheumatol 2010;37:1878–84.
    1. Macfarlane GJ, Barnish MS, Pathan E. et al. The co-occurrence and characteristics of patients with axial spondyloarthritis who meet criteria for fibromyalgia: results from a UK national register (BSRBR-AS). Arthritis Rheumatol 2017;69:2144–50.
    1. Wach J, Letroublon M-C, Coury F, Tebib JG.. Fibromyalgia in spondyloarthritis: effect on disease activity assessment in clinical practice. J Rheumatol 2016;43:2056–63.
    1. Aloush V, Ablin JN, Reitblat T, Caspi D, Elkayam O.. Fibromyalgia in women with ankylosing spondylitis. Rheumatol Int 2007;27:865–8.
    1. Azevedo VF, Paiva Edos S, Felippe LR, Moreira RA.. Occurrence of fibromyalgia in patients with ankylosing spondylitis. Rev Bras Reum 2010;50:646–50.
    1. Demirdal S, Çakir T, Tugrul T, Subaşi V.. Coexisting of fibromyalgia syndrome and ankylosing spondylitis. Acta Medica Mediterranea 2013;29:827–833.
    1. Salaffi F, De Angelis R, Carotti M. et al. Fibromyalgia in patients with axial spondyloarthritis: epidemiological profile and effect on measures of disease activity. Rheumatol Int 2014;34:1103–10.
    1. Brikman S, Furer V, Wollman J. et al. The effect of the presence of fibromyalgia on common clinical disease activity indices in patients with psoriatic arthritis: a Cross-sectional Study. J Rheumatol 2016;43:1749–54.
    1. Salaffi F, Gerardi MC, Atzeni F. et al. The influence of fibromyalgia on achieving remission in patients with long-standing rheumatoid arthritis. Rheumatol Int 2017;37:2035–42.
    1. Lee YC, Bingham CO, Edwards RR. et al. Pain sensitization is associated with disease activity in rheumatoid arthritis patients: a cross-sectional study. Arthritis Care Res 2018;70:197–204.
    1. Prevoo MLL, Van’T Hof MA, Kuper HH. et al. Modified disease activity scores that include twenty‐eight‐joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44–8.
    1. Alamanos Y, Drosos AA.. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev. 2005;4:130–6.
    1. Gladman DD, Antoni C, Mease P, Clegg DO, Nash P.. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis. 2005;64 (Suppl 2):ii14–7.
    1. Gran JT, Husby G.. The epidemiology of ankylosing spondylitis. Semin Arthritis Rheum 1993;22:319–34.
    1. Wolfe F, Clauw DJ, Fitzcharles MA. et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 2010;62:600–10.

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