Nutritional Assessment of Childhood Cancer Survivors (the Swiss Childhood Cancer Survivor Study-Nutrition): Protocol for a Multicenter Observational Study

Fabiën Naomi Belle, Maja Beck Popovic, Marc Ansari, Maria Otth, Claudia Elisabeth Kuehni, Murielle Bochud, Fabiën Naomi Belle, Maja Beck Popovic, Marc Ansari, Maria Otth, Claudia Elisabeth Kuehni, Murielle Bochud

Abstract

Background: Childhood cancer survivors are at high risk of developing adverse late health effects. Poor nutritional intake may contribute to this risk, but information about dietary intake is limited.

Objective: This study will assess childhood cancer survivors' dietary intake and compare two dietary assessment tools: a self-reported food frequency questionnaire, and dietary measurements from urine spot samples.

Methods: In a substudy of the Swiss Childhood Cancer Survivor Study (SCCSS), SCCSS-Nutrition, we assessed childhood cancer survivors' dietary intake via a validated food frequency questionnaire. We sent a urine spot collection kit to a subset of 212 childhood cancer survivors from the French-speaking region of Switzerland to analyze urinary sodium, potassium, urea, urate, creatinine, and phosphate content. We will compare the food frequency questionnaire results with the urine spot analyses to quantify childhood cancer survivors' intake of various nutrients. We collected data between March 2016 and March 2018.

Results: We contacted 1599 childhood cancer survivors, of whom 919 (57.47%) returned a food frequency questionnaire. We excluded 11 childhood cancer survivors who were pregnant or were breastfeeding, 35 with missing dietary data, and 71 who had unreliable food frequency questionnaire data, resulting in 802 childhood cancer survivors available for food frequency questionnaire analyses. To a subset of 212 childhood cancer survivors in French-speaking Switzerland we sent a urine spot collection kit, and 111 (52.4%) returned a urine sample. We expect to have the results from analyses of these samples in mid-2019.

Conclusions: The SCCSS-Nutrition study has collected in-depth dietary data that will allow us to assess dietary intake and quality and compare two dietary assessment tools. This study will contribute to the knowledge of nutrition among childhood cancer survivors and is a step toward surveillance guidelines and targeted nutritional recommendations for childhood cancer survivors in Switzerland.

Trial registration: ClinicalTrials.gov NCT03297034; https://ichgcp.net/clinical-trials-registry/NCT03297034.

International registered report identifier (irrid): DERR1-10.2196/14427.

Keywords: Swiss Childhood Cancer Registry; Switzerland; cancer survivors; child; diet surveys; food frequency questionnaire; urine specimen collection.

Conflict of interest statement

Conflicts of Interest: None declared.

©Fabiën Belle, Maja Beck Popovic, Marc Ansari, Maria Otth, Claudia Elisabeth Kuehni, Murielle Bochud. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 18.11.2019.

Figures

Figure 1
Figure 1
Response rates in the Swiss Childhood Cancer Survivor Study (SCCSS)-Nutrition study. The SCCSS-Nutrition study is subdivided into a food frequency questionnaire assessment (FFQ; gray) and a urine spot collection (black).
Figure 2
Figure 2
Timelines and response rates of food frequency questionnaire (FFQ) assessment and urine spot collection.

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