AICDA expression in BCR/ABL1-positive acute lymphoblastic leukaemia is associated with a peculiar gene expression profile
Monica Messina, Sabina Chiaretti, Ilaria Iacobucci, Simona Tavolaro, Annalisa Lonetti, Simona Santangelo, Loredana Elia, Cristina Papayannidis, Francesca Paoloni, Antonella Vitale, Anna Guarini, Giovanni Martinelli, Robin Foà, Monica Messina, Sabina Chiaretti, Ilaria Iacobucci, Simona Tavolaro, Annalisa Lonetti, Simona Santangelo, Loredana Elia, Cristina Papayannidis, Francesca Paoloni, Antonella Vitale, Anna Guarini, Giovanni Martinelli, Robin Foà
Abstract
Activation-induced cytidine deaminase (AICDA) initiates somatic hypermutation and class-switch recombination of immunoglobulin (Ig) genes and induces mutations also in non-Ig genes. AICDA aberrant expression was detected in B-lineage acute lymphoblastic leukaemia (B-ALL), particularly BCR/ABL1+ B-ALL; patients expressing AICDA carried more copy number alterations than 'AICDA-negative' cases. To determine the role of AICDA, AICDA expression and gene expression profiling were studied in adult BCR/ABL1+ B-ALL. Patients displaying the full-length isoform AICDA are characterized by up-regulation of DNA repair/replication and cell cycle genes, suggesting their involvement in the genetic instability of BCR/ABL1+ B-ALL.
Trial registration: ClinicalTrials.gov NCT00391989 NCT00458848.
© 2011 Blackwell Publishing Ltd.
Source: PubMed