Brain Activity Response to Visual Cues for Gait Impairment in Parkinson's Disease: An EEG Study

Samuel Stuart, Johanna Wagner, Scott Makeig, Martina Mancini, Samuel Stuart, Johanna Wagner, Scott Makeig, Martina Mancini

Abstract

Background. Gait impairments are common in Parkinson's disease (PD) and increase falls risk. Visual cues can improve gait in PD, particularly freezing of gait (FOG), but mechanisms involved in visual cue response are unknown. This study aimed to examine brain activity in response to visual cues in people with PD who do (PD+FOG) and do not report FOG (PD-FOG) and explore relationships between attention, brain activity and gait. Methods. Mobile EEG measured brain activity during gait in 20 healthy older adults and 43 PD participants (n=22 PD+FOG, n=21 PD-FOG). Participants walked for 2-minutes with and without visual cues (transverse lines to step over). We report power spectral density (PSD) in Delta (1-4 Hz), Theta (4-7 Hz), Alpha (8-12 Hz), Beta (14-24 Hz) and Gamma (30-50 Hz) bands within clusters of similarly brain localized independent component sources. Results. PSDs within the parietal and occipital lobes were altered when walking with visual cues in PD, particularly in PD+FOG. Between group, differences suggested that parietal sources in PD, particularly with PD+FOG, had larger activity compared to healthy older adults when walking. Within group, visual cues altered brain activity in PD, particularly in PD+FOG, within visual processing brain regions. In PD participants, brain activity differences with cues correlated with gait improvements, and in PD+FOG those with worse attention required more visual attentional processing (reduced alpha PSD) in the occipital lobe. Conclusions. Visual cues improve gait and influence brain activity during walking in PD, particularly in PD+FOG. Findings may allow development of more effective therapeutics.

Keywords: Parkinson’s disease; brain activity; electroencephalography; visual cues; walking.

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Power Spectral Densities in Brain Cluster Locations in people with PD (PD-FOG and PD+FOG) and healthy controls when walking with and without visual cues [Scalp maps, dipole cluster locations and Log PSDs, Significant (P < .05) differences in PSDs denoted by black bar on x axis].
Figure 2.
Figure 2.
Power spectral density of the left parietal cortex when walking without and with visual cues in people with PD (PD-FOG, PD+FOG) and health controls [significant (P<.05) differences in PSDs denoted by black bar on x axis].

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