Predictors and outcomes of side branch occlusion after main vessel stenting in coronary bifurcation lesions: results from the COBIS II Registry (COronary BIfurcation Stenting)
Joo-Yong Hahn, Woo Jung Chun, Ji-Hwan Kim, Young Bin Song, Ju Hyeon Oh, Bon-Kwon Koo, Seung Woon Rha, Cheol Woong Yu, Jong-Sun Park, Jin-Ok Jeong, Seung-Hyuk Choi, Jin-Ho Choi, Myung-Ho Jeong, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Hyo-Soo Kim, Hyeon-Cheol Gwon, Joo-Yong Hahn, Woo Jung Chun, Ji-Hwan Kim, Young Bin Song, Ju Hyeon Oh, Bon-Kwon Koo, Seung Woon Rha, Cheol Woong Yu, Jong-Sun Park, Jin-Ok Jeong, Seung-Hyuk Choi, Jin-Ho Choi, Myung-Ho Jeong, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Hyo-Soo Kim, Hyeon-Cheol Gwon
Abstract
Objectives: This study sought to investigate the predictors and outcomes of side branch (SB) occlusion after main vessel (MV) stenting in coronary bifurcation lesions.
Background: SB occlusion is a serious complication that occurs during percutaneous coronary intervention (PCI) for bifurcation lesions.
Methods: Consecutive patients undergoing PCI using drug-eluting stents for bifurcation lesions with SB ≥2.3 mm were enrolled. We selected patients treated with the 1-stent technique or MV stenting first strategy. SB occlusion after MV stenting was defined as Thrombolysis in Myocardial Infarction flow grade <3.
Results: SB occlusion occurred in 187 (8.4%) of 2,227 bifurcation lesions. In multivariate analysis, independent predictors of SB occlusion were pre-procedural percent diameter stenosis of the SB ≥50% (odds ratio [OR]: 2.34; 95% confidence interval [CI]: 1.59 to 3.43; p < 0.001) and the proximal MV ≥50% (OR: 2.34; 95% CI: 1.57 to 3.50; p < 0.001), SB lesion length (OR: 1.03; 95% CI: 1.003 to 1.06; p = 0.03), and acute coronary syndrome (OR: 1.53; 95% CI: 1.06 to 2.19; p = 0.02). Of 187 occluded SBs, flow was restored spontaneously in 26 (13.9%) and by SB intervention in 103 (55.1%) but not in 58 (31.0%). Jailed wire in the SB was associated with flow recovery (74.8% vs. 57.8%, p = 0.02). Cardiac death or myocardial infarction occurred more frequently in patients with SB occlusion than in those without SB occlusion (adjusted hazard ratio: 2.34; 95% CI: 1.15 to 4.77; p = 0.02).
Conclusions: Angiographic findings of SB, proximal MV stenosis, and clinical presentation are predictive of SB occlusion after MV stenting. Occlusion of sizable SB is associated with adverse clinical outcomes..
Trial registration: ClinicalTrials.gov NCT01642992.
Keywords: DES; IVUS; MACE; MI; MV; PCI; SB; TIMI; TLR; Thrombolysis In Myocardial Infarction; angioplasty; bifurcation lesion; drug-eluting stent(s); intravascular ultrasound; main vessel; major adverse cardiac event(s); myocardial infarction; percutaneous coronary intervention; side branch; target lesion revascularization.
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Source: PubMed