Chemotherapy-Induced Intestinal Mucosal Barrier Damage: a Cause of Falsely Elevated Serum 1,3-Beta-d-Glucan Levels?

Juergen Prattes, Reinhard B Raggam, Kim Vanstraelen, Jasmin Rabensteiner, Christoph Hoegenauer, Robert Krause, Florian Prüller, Albert Wölfler, Isabel Spriet, Martin Hoenigl, Juergen Prattes, Reinhard B Raggam, Kim Vanstraelen, Jasmin Rabensteiner, Christoph Hoegenauer, Robert Krause, Florian Prüller, Albert Wölfler, Isabel Spriet, Martin Hoenigl

Abstract

Blood citrulline and intestinal fatty acid binding protein were determined as biomarkers for intestinal mucositis. Biomarker levels were correlated with corresponding serum 1,3-beta-D-glucan levels in 56 samples obtained from 33 cases with underlying hematological malignancies receiving induction chemotherapy. No correlation between biomarkers of intestinal mucositis and BDG levels was observed. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.).

Figures

**FIG 1**
Correlation of 1,3-beta-d-glucan (BDG) with citrulline and intestinal fatty acid binding protein (IFABP) in same-day plasma and serum samples. Correlation analyses were performed by Spearman ρ analysis and yielded no significant correlations between BDG and citrulline (r = 0.081) and BDG and IFABP (r = 0.048).

Source: PubMed

Chemotherapy-Induced Intestinal Mucosal Barrier Damage: a Cause of Falsely Elevated Serum 1,3-Beta-d-Glucan Levels?

Abstract

Figures

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