In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to Michele Di Mascio 1 , Geethanjali Dornadula, Hui Zhang, Julie Sullivan, Yan Xu, Joseph Kulkosky, Roger J Pomerantz, Alan S Perelson Affiliations Expand Affiliation 1 Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. PMID: 12525664 PMCID: PMC140859 DOI: 10.1128/jvi.77.3.2271-2275.2003 Free PMC article Item in Clipboard
Michele Di Mascio, Geethanjali Dornadula, Hui Zhang, Julie Sullivan, Yan Xu, Joseph Kulkosky, Roger J Pomerantz, Alan S Perelson, Michele Di Mascio, Geethanjali Dornadula, Hui Zhang, Julie Sullivan, Yan Xu, Joseph Kulkosky, Roger J Pomerantz, Alan S Perelson
Abstract
Three of five virally suppressed human immunodeficiency virus type I (HIV-1)-infected patients treated with highly active antiretroviral therapy and followed intensively with a supersensitive reverse transcriptase PCR assay with a lower limit of quantitation of 5 copies/ml showed statistically significant viral load decays below 50 copies/ml, with half-lives of 5 to 8 months and a mean of 6 months. This range of half-lives is consistent with the estimated half-life of the latent HIV-1 reservoir in the peripheral blood. Those patients without decay of viral load in plasma may have significant cryptic HIV-1 residual replication.
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Source: PubMed