Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis
Marc R Dweck, Sanjiv Joshi, Timothy Murigu, Francisco Alpendurada, Andrew Jabbour, Giovanni Melina, Winston Banya, Ankur Gulati, Isabelle Roussin, Sadaf Raza, Nishant A Prasad, Rick Wage, Cesare Quarto, Emiliano Angeloni, Simone Refice, Mary Sheppard, Stuart A Cook, Philip J Kilner, Dudley J Pennell, David E Newby, Raad H Mohiaddin, John Pepper, Sanjay K Prasad, Marc R Dweck, Sanjiv Joshi, Timothy Murigu, Francisco Alpendurada, Andrew Jabbour, Giovanni Melina, Winston Banya, Ankur Gulati, Isabelle Roussin, Sadaf Raza, Nishant A Prasad, Rick Wage, Cesare Quarto, Emiliano Angeloni, Simone Refice, Mary Sheppard, Stuart A Cook, Philip J Kilner, Dudley J Pennell, David E Newby, Raad H Mohiaddin, John Pepper, Sanjay K Prasad
Abstract
Objectives: The goal of this study was to assess the prognostic significance of midwall and infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis.
Background: Myocardial fibrosis occurs in aortic stenosis as part of the hypertrophic response. It can be detected by LGE, which is associated with an adverse prognosis in a range of other cardiac conditions.
Methods: Between January 2003 and October 2008, consecutive patients with moderate or severe aortic stenosis undergoing cardiovascular magnetic resonance with administration of gadolinium contrast were enrolled into a registry. Patients were categorized into absent, midwall, or infarct patterns of LGE by blinded independent observers. Patient follow-up was completed using patient questionnaires, source record data, and the National Strategic Tracing Service.
Results: A total of 143 patients (age 68 ± 14 years; 97 male) were followed up for 2.0 ± 1.4 years. Seventy-two underwent aortic valve replacement, and 27 died (24 cardiac, 3 sudden cardiac deaths). Compared with those with no LGE (n = 49), univariate analysis revealed that patients with midwall fibrosis (n = 54) had an 8-fold increase in all-cause mortality despite similar aortic stenosis severity and coronary artery disease burden. Patients with an infarct pattern (n = 40) had a 6-fold increase. Midwall fibrosis (hazard ratio: 5.35; 95% confidence interval: 1.16 to 24.56; p = 0.03) and ejection fraction (hazard ratio: 0.96; 95% confidence interval: 0.94 to 0.99; p = 0.01) were independent predictors of all-cause mortality by multivariate analysis.
Conclusions: Midwall fibrosis was an independent predictor of mortality in patients with moderate and severe aortic stenosis. It has incremental prognostic value to ejection fraction and may provide a useful method of risk stratification.
Trial registration: ClinicalTrials.gov NCT00930735.
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Source: PubMed