The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults

Amanda V Tyndall, Margie H Davenport, Ben J Wilson, Grazyna M Burek, Genevieve Arsenault-Lapierre, Eryka Haley, Gail A Eskes, Christine M Friedenreich, Michael D Hill, David B Hogan, R Stewart Longman, Todd J Anderson, Richard Leigh, Eric E Smith, Marc J Poulin, Amanda V Tyndall, Margie H Davenport, Ben J Wilson, Grazyna M Burek, Genevieve Arsenault-Lapierre, Eryka Haley, Gail A Eskes, Christine M Friedenreich, Michael D Hill, David B Hogan, R Stewart Longman, Todd J Anderson, Richard Leigh, Eric E Smith, Marc J Poulin

Abstract

Background: Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is becoming an increasingly important population health issue. Emerging research suggests that higher levels of physical fitness at any age are associated with better cognitive functioning and this may be mediated, at least in part, by improvements in cerebrovascular reserve. We are currently conducting a study to determine: if a structured 6-month aerobic exercise program is associated with improvements or maintenance of both cerebrovascular function and cognitive abilities in older individuals; and, the extent to which any changes seen persist 6 months after the completion of the structured exercise program.

Methods/design: Two hundred and fifty men and women aged 55-80 years are being enrolled into an 18-month combined quasi-experimental and prospective cohort study. Participants are eligible for enrollment into the study if they are inactive (i.e., not participating in regular physical activity), non-smokers, have a body mass index <35.0 kg/m(2), are free of significant cognitive impairment (defined as a Montreal Cognitive Assessment score of 24 or more), and do not have clinically significant cardiovascular, cerebrovascular disease, or chronic obstructive pulmonary airway disease. Repeated measurements are done during three sequential six-month phases: 1) pre-intervention; 2) aerobic exercise intervention; and 3) post-intervention. These outcomes include: cardiorespiratory fitness, resting cerebral blood flow, cerebrovascular reserve, and cognitive function.

Discussion: This is the first study to our knowledge that will examine contemporaneously the effect of an exercise intervention on both cerebrovascular reserve and cognition in an older population. This study will further our understanding of whether cerebrovascular mechanisms might explain how exercise promotes healthy brain aging. In addition our study will address the potential of increasing physical activity to prevent age-associated cognitive decline.

Figures

Figure 1
Figure 1
Flow chart of the phases of the BIM study.

References

    1. Middleton LE, Barnes DE, Lui L, Yaffe K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc. 2010;58(7):1322–1326. doi: 10.1111/j.1532-5415.2010.02903.x.
    1. Public Health Agency of Canada- Physical Activity and Older Adults. .
    1. Dementia: A Public Health Priority. .
    1. Canada’s Physical Activity Guide to Healthy Active Living for Older Adults. .
    1. Gorelick PB, Sacco RL, Smith DB, Alberts M, Mustone-Alexander L, Rader D, Ross JL, Raps E, Ozer MN, Brass LM, Malone ME, Goldberg S, Booss J, Hanley DF, Toole JF, Greengold NL, Rhew DC. Prevention of a first stroke: a review of guidelines and a multidisciplinary consensus statement from the national stroke association. J Am Med Assoc. 1999;281(12):1112–1120. doi: 10.1001/jama.281.12.1112.
    1. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58(3):498–504. doi: 10.1001/archneur.58.3.498.
    1. Statistics Canada 2010- Population projections. Canada, the provinces and territories (2009–2036) .
    1. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010;464(7288):529–535. doi: 10.1038/nature08983.
    1. Grady C. The cognitive neuroscience of ageing. Nat Rev Neurosci. 2012;13(7):491–505. doi: 10.1038/nrn3256.
    1. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the national institute on aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–279. doi: 10.1016/j.jalz.2011.03.008.
    1. Silvestrini M, Pasqualetti P, Baruffaldi R, Bartolini M, Handouk Y, Matteis M, Moffa F, Provinciali L, Vernieri F. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke. 2006;37(4):1010–1015. doi: 10.1161/01.STR.0000206439.62025.97.
    1. Brown AD, McMorris CA, Longman RS, Leigh R, Hill MD, Friedenreich CM, Poulin MJ. Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women. Neurobiol Aging. 2010;31(12):2047–2057. doi: 10.1016/j.neurobiolaging.2008.11.002.
    1. Riecker A, Grodd W, Klose U, Schulz JB, Gröschel K, Erb M, Ackermann H, Kastrup A. Relation between regional functional MRI activation and vascular reactivity to carbon dioxide during normal aging. J Cereb Blood Flow Metab. 2003;23(5):565–573.
    1. Grolimund P, Seiler RW. Age dependence of the flow velocity in the basal cerebral arteries - a transcranial Doppler ultrasound study. Ultrasound Med Biol. 1988;14(3):191–198. doi: 10.1016/0301-5629(88)90139-1.
    1. Davenport MH, Hogan DB, Eskes GA, Longman RS, Poulin MJ. Cerebrovascular reserve: the link between fitness and cognitive function? Exerc Sport Sci Rev. 2012;40(3):153–158.
    1. Cunnane S, Nugent S, Roy M, Courchesne-Loyer A, Croteau E, Tremblay S, Castellano A, Pifferi F, Bocti C, Paquet N, Begdouri H, Bentourkia M, Turcotte E, Allard M, Barberger-Gateau P, Fulop T, Rapoport SI. Brain fuel metabolism, aging, and Alzheimer’s disease. Nutrition. 2011;27(1):3–20. doi: 10.1016/j.nut.2010.07.021.
    1. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer’s disease. Nat Rev Neurosci. 2004;5(5):347–360. doi: 10.1038/nrn1387.
    1. Girouard H, Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol. 2006;100(1):328–335. doi: 10.1152/japplphysiol.00966.2005.
    1. Attwell D, Iadecola C. The neural basis of functional brain imaging signals. Trends Neurosci. 2002;25(12):621–625. doi: 10.1016/S0166-2236(02)02264-6.
    1. Ahlskog JE, Geda YE, Graff-Radford NR, Petersen RC. Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin Proc. 2011;86(9):876–884. doi: 10.4065/mcp.2011.0252.
    1. Eskes GA, Longman S, Brown AD, McMorris CA, Langdon KD, Hogan DB, Poulin M. Contribution of physical fitness, cerebrovascular reserve and cognitive stimulation to cognitive function in postmenopausal women. Front Aging Neurosci. 2010;2:1–7.
    1. Voss MW, Nagamatsu LS, Liu-Ambrose T, Kramer AF. Exercise, brain, and cognition across the life span. J Appl Physiol. 2011;111(5):1505–1513. doi: 10.1152/japplphysiol.00210.2011.
    1. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108(7):3017–3022. doi: 10.1073/pnas.1015950108.
    1. Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L, Kramer AF. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006;61(11):1166–1170. doi: 10.1093/gerona/61.11.1166.
    1. Burns JM, Cronk BB, Anderson HS, Donnelly JE, Thomas GP, Harsha A, Brooks WM, Swerdlow RH. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology. 2008;71(3):210–216. doi: 10.1212/01.wnl.0000317094.86209.cb.
    1. Middleton LE, Yaffe K. Promising strategies for the prevention of dementia. Arch Neurol. 2009;66(10):1210–1215. doi: 10.1001/archneurol.2009.201.
    1. Churchill JD, Galvez R, Colcombe S, Swain RA, Kramer AF, Greenough WT. Exercise, experience and the aging brain. Neurobiol Aging. 2002;23(5):941–955. doi: 10.1016/S0197-4580(02)00028-3.
    1. Ainslie PN, Cotter JD, George KP, Lucas S, Murrell C, Shave R, Thomas KN, Williams MJA, Atkinson G. Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. J Physiol (Lond ) 2008;586(16):4005–4010. doi: 10.1113/jphysiol.2008.158279.
    1. Rossetti HC, Lacritz LH, Munro Cullum C, Weiner MF. Normative data for the Montreal cognitive assessment (MoCA) in a population-based sample. Neurology. 2011;77(13):1272–1275. doi: 10.1212/WNL.0b013e318230208a.
    1. Csizmadi I, Kahle L, Ullman R, Dawe U, Zimmerman TP, Friedenreich CM, Bryant H, Subar AF. Adaptation and evaluation of the national cancer Institute’s diet history questionnaire and nutrient database for Canadian populations. Public Health Nutr. 2007;10(1):88–96.
    1. Friedenreich CM, Courneya KS, Bryant HE. The lifetime total physical activity questionnaire: development and reliability. Med Sci Sports Exerc. 1998;30(2):266–274. doi: 10.1097/00005768-199802000-00015.
    1. Thompson WR, Gordon NF, Pescatello LS, American College of Sports Medicine. ASCM’s guidelines for exercise testing and prescription. 8. Philadelphia: Lippincott Williams & Wilkins; 2010.
    1. Friedenreich CM, Courneya KS, Neilson HK, Matthews CE, Willis G, Irwin M, Troiano R, Ballard-Barbash R. Reliability and validity of the past year total physical activity questionnaire. Am J Epidemiol. 2006;163(10):959–970. doi: 10.1093/aje/kwj112.
    1. Pialoux V, Brown AD, Leigh R, Friedenreich CM, Poulin MJ. Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women. Hypertension. 2009;54(5):1014–1020. doi: 10.1161/HYPERTENSIONAHA.109.138917.
    1. Barnett JH, Jones PB, Muller U, Robbins TW. Effects of the catechol-O-methyltransferase Val.sup.158]Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry. 2007;12:502+.
    1. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90(5):1977–1981. doi: 10.1073/pnas.90.5.1977.
    1. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci. 2004;20(10):2580–2590. doi: 10.1111/j.1460-9568.2004.03720.x.
    1. Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popović J, Blalock EM, Landfield PW, Thibault O, Porter NM. Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS One. 2011;6(10):e26812. doi: 10.1371/journal.pone.0026812.
    1. Paterson DH, Cunningham DA, Koval JJ, St. Croix CM. Aerobic fitness in a population of independently living men and women aged 55–86 years. Med Sci Sports Exerc. 1999;31(12):1813–1820. doi: 10.1097/00005768-199912000-00018.
    1. Canadian Society for Exercise Physiology. Professional Fitness and Lifestyle Consultant: Resource Manual, Canadian Society for Exercise Physiology. Ottawa: Canadian Society for Exercise Physiology; 1996.
    1. Anonymous. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003;167(2):211–277.
    1. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982;57(6):769–774. doi: 10.3171/jns.1982.57.6.0769.
    1. Poulin MJ, Liang P, Robbins PA. Dynamics of the cerebral blood flow response to step changes in end- tidal PCO2 and PO2 in humans. J Appl Physiol. 1996;81(3):1084–1095.
    1. Lambertsen CJ. Invited Editorial on ‘Fast and slow components of cerebral blood flow response to step decreases in end-tidal PCO2 in humans’. J Appl Physiol. 1998;85(2):386–387.
    1. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–130. doi: 10.1111/1467-9280.t01-1-01430.
    1. McNair D, Lorr M, Droppleman L. Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service; 1981.
    1. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213. doi: 10.1016/0165-1781(89)90047-4.
    1. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–545.
    1. Kremen WS, Lachman ME, Pruessner JC, Sliwinski M, Wilson RS. Mechanisms of age-related cognitive change and targets for intervention: social interactions and stress. J Gerontol A Biol Sci Med Sci. 2012;67 A(7):760–765.
    1. Lubben J, Blozik E, Gillmann G, Iliffe S, Von Kruse WR, Beck JC, Stuck AE. Performance of an abbreviated version of the lubben social network scale among three European community-dwelling older adult populations. Gerontologist. 2006;46(4):503–513. doi: 10.1093/geront/46.4.503.
    1. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci. 2002;14(3):340–347. doi: 10.1162/089892902317361886.
    1. Callejas A, Lupiàñez J, Funes MJ, Tudela P. Modulations among the alerting, orienting and executive control networks. Exp Brain Res. 2005;167(1):27–37. doi: 10.1007/s00221-005-2365-z.
    1. Posner MI, Petersen SE. The attentional system of the human brain. Annu Rev Neurosci. 1990;13:25–42. doi: 10.1146/annurev.ne.13.030190.000325.
    1. Stuss DT, Stethem LL, Poirier CA. Comparison of three tests of attention and rapid information processing across six age groups. Clin Neuropsychol. 1987;1(2):139–152. doi: 10.1080/13854048708520046.
    1. Lezak M. Neuropsychological Assessment. New York: Oxford University Press; 2004.
    1. Buschke H, Altman Fuld P. Evaluating storage, retention and retrieval in disordered memory and learning. Neurology. 1974;24(11):1019–1025. doi: 10.1212/WNL.24.11.1019.
    1. Hannay HJ, Levin HS. Selective reminding test: an examination of the equivalence of four forms. J Clin Exp Neuropsychol. 1985;7(3):251–263. doi: 10.1080/01688638508401258.
    1. Meador KJ, Moore EE, Nichols ME, Abney OL, Taylor HS, Zamrini EY, Loring DW. The role of cholinergic systems in visuospatial processing and memory. J Clin Exp Neuropsychol. 1993;15(5):832–842. doi: 10.1080/01688639308402599.
    1. Delis DC, Kaplan E, Kramer JH. Delis Kaplan Executive Functioning System (D-KEFS) San Antonio: NCS Pearson, Inc; 2001.
    1. Uttl B. North American adult reading test: Age norms, reliability, and validity. J Clin Exp Neuropsychol. 2002;24(8):1123–1137. doi: 10.1076/jcen.24.8.1123.8375.
    1. Nyenhuis DL, Yamamoto C, Lucheta T, Terrien A, Parmentier A. Adult and geriatric normative data and validation of the profile of mood states. J Clin Psychol. 1999;55(1):79–86. doi: 10.1002/(SICI)1097-4679(199901)55:1<79::AID-JCLP8>;2-7.
    1. Wilson RS, Bennett DA, Beckett LA, Morris MC, Gilley DW, Bienias JL, Scherr PA, Evans DA. Cognitive activity in older persons from a geographically defined population. J Gerontol B Psychol Sci Soc Sci. 1999;54(3):P155–P160.
    1. Deley G, Kervio G, Van Hoecke J, Verges B, Grassi B, Casillas J. Effects of a one-year exercise training program in adults over 70 years old: a study with a control group. Aging Clin Exp Res. 2007;19(4):310–315.
    1. Lautenschlager NT, Cox KL, Flicker L, Foster JK, Van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027–1037. doi: 10.1001/jama.300.9.1027.
    1. Rodahl K, Per-Olof êAstrand. From evaluation of physical performance on the basis of tests. McGraw-Hill; 2003. pp. 273–299. (Textbook of Work Physiology: Physiological Bases of Exercise.Volume 4).

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