Implementation of evidence-based practice for benign paroxysmal positional vertigo: DIZZTINCT- A study protocol for an exploratory stepped-wedge randomized trial

William J Meurer, Kathryn E Beck, Brigid Rowell, Devin Brown, Alexander Tsodikov, Angela Fagerlin, Steven A Telian, Laura Damschroder, Lawrence C An, Lewis B Morgenstern, Misty Ujhely, Laura Loudermilk, Sandeep Vijan, Kevin A Kerber, William J Meurer, Kathryn E Beck, Brigid Rowell, Devin Brown, Alexander Tsodikov, Angela Fagerlin, Steven A Telian, Laura Damschroder, Lawrence C An, Lewis B Morgenstern, Misty Ujhely, Laura Loudermilk, Sandeep Vijan, Kevin A Kerber

Abstract

Background: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder, and accounts for 8% of individuals with moderate or severe dizziness. BPPV patients experience substantial inconveniences and disabilities during symptomatic periods. BPPV therapeutic processes - the Dix-Hallpike Test (DHT) and the Canalith Repositioning Maneuver (CRM) - have an evidence base that is at the clinical practice guideline level. The most commonly used CRM is the modified Epley maneuver. The DHT is the gold standard test for BPPV and the CRM is supported by numerous randomized controlled trials and systematic reviews. Despite this, BPPV care processes are underutilized.

Methods/design: This is a stepped-wedge, randomized clinical trial of a multi-faceted educational and care-process-based intervention designed to improve the guideline-concordant care of patients with BPPV presenting to the emergency department (ED) with dizziness. The unit of randomization and target of intervention is the hospital. After an initial observation period, the six hospitals will undergo the intervention in five waves (two closely integrated hospitals will be paired). The order will be randomized. The primary endpoint is measured at the individual patient level, and is the presence of documentation of either the Dix-Hallpike Test or CRM. The secondary endpoints are referral to a health care provider qualified to treat dizziness for CRM and 90-day stroke rates following an ED dizziness visit. Formative evaluations are also performed to monitor and identify potential and actual influences on the progress and effectiveness of the implementation efforts.

Discussion: If this study safely increases documentation of the DHT/CRM, this will be an important step in implementing the use of these evidenced-based processes of care. Positive results will support conducting larger-scale follow-up studies that assess patient outcomes. The data collection also enables evaluation of potential and actual influences on the progress and effectiveness of the implementation efforts.

Trial registration: ClinicalTrials.gov, ID: NCT02809599 . The record was first available to the public on 22 June 2016 prior to the enrollment of the first patients in October 2016.

Keywords: Benign paroxysmal peripheral vertigo; Clinical trial; Emergency medicine; Stepped wedge.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

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Fig. 1
Timing of study events at hospital level

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Source: PubMed

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