Host susceptibility to severe influenza A virus infection

Sara Clohisey, John Kenneth Baillie, Sara Clohisey, John Kenneth Baillie

Abstract

Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial inoculum or the influenza exposure history of the individual; some is explained by generic host factors, such as frailty, that decrease resilience following any systemic insult. Some demographic factors (pregnancy, obesity, and advanced age) appear to confer a more specific susceptibility to severe illness following infection with influenza viruses. As with other infectious diseases, a substantial component of susceptibility is determined by host genetics. Several genetic susceptibility variants have now been reported with varying levels of evidence. Susceptible hosts may have impaired intracellular controls of viral replication (e.g. IFITM3, TMPRS22 variants), defective interferon responses (e.g. GLDC, IRF7/9 variants), or defects in cell-mediated immunity with increased baseline levels of systemic inflammation (obesity, pregnancy, advanced age). These mechanisms may explain the prolonged viral replication reported in critically ill patients with influenza: patients with life-threatening disease are, by definition, abnormal hosts. Understanding these molecular mechanisms of susceptibility may in the future enable the design of host-directed therapies to promote resilience.

Keywords: ARDS; Genetics; Influenza; Susceptibility.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Conceptual visualisation of variation in specificity of host susceptibility factors. Factors predicted to confer more specific susceptibility to influenza are placed higher in the diagram

References

    1. Hayward AC, Fragaszy EB, Bermingham A, Wang L, Copas A, Edmunds WJ, Ferguson N, Goonetilleke N, Harvey G, Kovar J, Lim MSC, McMichael A, Millett ERC, Nguyen-Van-Tam JS, Nazareth I, Pebody R, Tabassum F, Watson JM, Wurie FB, Johnson AM, Zambon M. Comparative community burden and severity of seasonal and pandemic influenza: results of the flu watch cohort study. Lancet Respir Med. 2014;2:445–454. doi: 10.1016/S2213-2600(14)70034-7.
    1. Rowan KM, Harrison DA, Walsh TS, McAuley DF, Perkins GD, Taylor BL, Menon DK. The Swine Flu Triage (SwiFT) study: development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic. Health Technol Assess. 2010;14:335–492. doi: 10.3310/hta14550-05.
    1. Frodsham, A.J. & Hill, A.V.S. Genetics of infectious diseases. Hum Mol Genet 13 Spec No 2, R187–R194(2004).
    1. Baillie JK. Targeting the host immune response to fight infection. Science. 2014;344:807–808. doi: 10.1126/science.1255074.
    1. Baillie JK, Digard P. Influenza to target the host? N Engl J Med. 2013;369:191–193. doi: 10.1056/NEJMcibr1304414.
    1. Slemons RD, Easterday BC. Type-a influenza viruses in the feces of migratory waterfowl. J Am Vet Med Assoc. 1977;171:947–948.
    1. Marois I, Cloutier A, Garneau É, Richter MV. Initial infectious dose dictates the innate, adaptive, and memory responses to influenza in the respiratory tract. J Leukoc Biol. 2012;92:107–121. doi: 10.1189/jlb.1011490.
    1. Memoli MJ, Czajkowski L, Reed S, Athota R, Bristol T, Proudfoot K, Fargis S, Stein M, Dunfee RL, Shaw PA, Davey RT, Taubenberger JK. Validation of the wild-type influenza a human challenge model H1N1pdmist: an a(H1N1)pdm09 dose-finding investigational new drug study. Clin Infect Dis. 2015;60:693–702. doi: 10.1093/cid/ciu924.
    1. Zitzow LA, Rowe T, Morken T, Shieh W-J, Zaki S, Katz JM. Pathogenesis of avian influenza a (h5n1) viruses in ferrets. J Virol. 2002;76:4420–4429. doi: 10.1128/JVI.76.9.4420-4429.2002.
    1. Ramos I, Krammer F, Hai R, Aguilera D, Bernal-Rubio D, Steel J, García-Sastre A, Fernandez-Sesma A. H7N9 influenza viruses interact preferentially with 2,3-linked sialic acids and bind weakly to 2,6-linked sialic acids. J General Virol. 2013;94:2417–2423. doi: 10.1099/vir.0.056184-0.
    1. Liu Y, Childs RA, Matrosovich T, Wharton S, Palma AS, Chai W, Daniels R, Gregory V, Uhlendorff J, Kiso M, Klenk H-D, Hay A, Feizi T, Matrosovich M. Altered receptor specificity and cell tropism of d222g hemagglutinin mutants isolated from fatal cases of pandemic a(H1N1) 2009 influenza virus. J Virol. 2010;84:12069–12074. doi: 10.1128/JVI.01639-10.
    1. Parvin JD, Moscona A, Pan WT, Leider JM, Palese P. Measurement of the mutation rates of animal viruses: influenza a virus and poliovirus type 1. J Virol. 1986;59:377–383.
    1. Suárez P, Valcárcel J, Ortín J. Heterogeneity of the mutation rates of influenza a viruses: isolation of mutator mutants. J Virol. 1992;66:2491–2494.
    1. Andino R, Domingo E. Viral quasispecies. Virology. 2015;479-480:46–51. doi: 10.1016/j.virol.2015.03.022.
    1. Graitcer SB, Gubareva L, Kamimoto L, Doshi S, Vandermeer M, Louie J, Waters C, Moore Z, Sleeman K, Okomo-Adhiambo M, Marshall SA, St. George K, Pan C-Y, LaPlante JM, Klimov A, Fry AM. Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States. Emerg Infect Dis. 2011;17:255–257. doi: 10.3201/eid1702.101724.
    1. Memoli MJ, Hrabal RJ, Hassantoufighi A, Eichelberger MC, Taubenberger JK. Rapid selection of oseltamivir and peramivir resistant pandemic H1N1 during therapy in two immunocompromised hosts. Clin Infect Dis. 2010;50:1252–1255. doi: 10.1086/651605.
    1. Tamura D, DeBiasi RL, Okomo-Adhiambo M, Mishin VP, Campbell AP, Loechelt B, Wiedermann BL, Fry AM, Gubareva LV. Emergence of multidrug-resistant influenza a(H1N1)pdm09 virus variants in an immunocompromised child treated with oseltamivir and zanamivir. J Infect Dis. 2015;212:1209–1213. doi: 10.1093/infdis/jiv245.
    1. Elderfield RA, Watson SJ, Godlee A, Adamson WE, Thompson CI, Dunning J, Fernandez-Alonso M, Blumenkrantz D, Hussell T, MOSAIC Investigators. Zambon M, Openshaw P, Kellam P, Barclay WS. Accumulation of human-adapting mutations during circulation of A(H1N1)Pdm09 influenza virus in humans in the United Kingdom. J Virol. 2014;88:13269–13283. doi: 10.1128/JVI.01636-14.
    1. Chiu C, Openshaw PJ. Antiviral B cell and T cell immunity in the lungs. Nat Immunol. 2015;16:18–26. doi: 10.1038/ni.3056.
    1. Francis T. Influenza: the new acquayantance. Ann Intern Med. 1953;39:203–221. doi: 10.7326/0003-4819-39-2-203.
    1. Gostic KM, Ambrose M, Worobey M, Lloyd-Smith JO. Potent protection against h5n1 and H7N9 influenza via childhood hemagglutinin imprinting. Science. 2016;354:722–726. doi: 10.1126/science.aag1322.
    1. Simonsen L, Spreeuwenberg P, Lustig R, Taylor RJ, Fleming DM, Kroneman M, Van Kerkhove MD, Mounts AW, Paget WJ. Global mortality estimates for the 2009 influenza pandemic from the glamor project: a modeling study. PLoS Med. 2013;10:e1001558. doi: 10.1371/journal.pmed.1001558.
    1. Wilkinson TM, Li CKF, Chui CSC, Huang AKY, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, Staples KJ, Dong T, Douek DC, McMichael AJ, Xu X-N. Preexisting influenza-specific cd4+ t cells correlate with disease protection against influenza challenge in humans. Nat Med. 2012;18:274–280. doi: 10.1038/nm.2612.
    1. Mertz D, Kim TH, Johnstone J, Lam P-P, Science M, Kuster SP, Fadel SA, Tran D, Fernandez E, Bhatnagar N, Loeb M. Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis. BMJ. 2013;347:f5061. doi: 10.1136/bmj.f5061.
    1. Cervantes-Gonzalez M, Launay O. Pandemic influenza a (H1N1) in pregnant women: impact of early diagnosis and antiviral treatment. Expert Rev Anti-Infect Ther. 2010;8:981–984. doi: 10.1586/eri.10.83.
    1. Neuzil KM, Reed GW, Mitchel EF, Simonsen L, Griffin MR. Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women. Am J Epidemiol. 1998;148:1094–1102. doi: 10.1093/oxfordjournals.aje.a009587.
    1. Siston AM, Rasmussen SA, Honein MA, Fry AM, Seib K, Callaghan WM, Louie J, Doyle TJ, Crockett M, Lynfield R, Moore Z, Wiedeman C, Anand M, Tabony L, Nielsen CF, Waller K, Page S, Thompson JM, Avery C, Springs CB, Jones T, Williams JL, Newsome K, Finelli L, Jamieson DJ. Pandemic 2009 influenza a(H1N1) virus illness among pregnant women in the United States. JAMA. 2010;303:1517–1525. doi: 10.1001/jama.2010.479.
    1. Fanelli V, Ranieri VM. Mechanisms and clinical consequences of acute lung injury. Ann Am Thorac Soc. 2015;12(Suppl 1):S3–S8. doi: 10.1513/AnnalsATS.201407-340MG.
    1. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014;370:2211–2218. doi: 10.1056/NEJMra1213566.
    1. Louie JK, Acosta M, Winter K, Jean C, Gavali S, Schechter R, Vugia D, Harriman K, Matyas B, Glaser CA, Samuel MC, Rosenberg J, Talarico J, Hatch D. Factors associated with death or hospitalization due to pandemic 2009 influenza a(H1N1) infection in California. JAMA. 2009;302:1896–1902. doi: 10.1001/jama.2009.1583.
    1. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293:1861–1867. doi: 10.1001/jama.293.15.1861.
    1. Louie JK, Acosta M, Samuel MC, Schechter R, Vugia DJ, Harriman K, Matyas BT. A novel risk factor for a novel virus: obesity and 2009 pandemic influenza a (H1N1) Clin Infect Dis. 2011;52:301–312. doi: 10.1093/cid/ciq152.
    1. Maier HE, Lopez R, Sanchez N, Ng S, Gresh L, Ojeda S, Burger-Calderon R, Kuan G, Harris E, Balmaseda A, Gordon A. Obesity increases the duration of influenza a virus shedding in adults. J Infect Dis. 2018;218:1378–1382. doi: 10.1093/infdis/jiy370.
    1. Nathan C. Epidemic inflammation: Pondering obesity. Mol Med. 2008;14:485–492. doi: 10.2119/2008-00038.Nathan.
    1. Neidich SD, Green WD, Rebeles J, Karlsson EA, Schultz-Cherry S, Noah TL, Chakladar S, Hudgens MG, Weir SS, Beck MA. Increased risk of influenza among vaccinated adults who are obese. Int J Obes. 2017;41:1324–1330. doi: 10.1038/ijo.2017.131.
    1. Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon AB, Holland LA, Weir S, Noah TL, Beck MA. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (London) 2012;36:1072–1077. doi: 10.1038/ijo.2011.208.
    1. Paich HA, Sheridan PA, Handy J, Karlsson EA, Schultz-Cherry S, Hudgens MG, Noah TL, Weir SS, Beck MA. Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza a virus. Obesity. 2013;21:2377–2386. doi: 10.1002/oby.20383.
    1. Wong KK, Jain S, Blanton L, Dhara R, Brammer L, Fry AM, Finelli L. Influenza-associated pediatric deaths in the United States, 2004-2012. Pediatrics. 2013;132:796–804. doi: 10.1542/peds.2013-1493.
    1. Cromer D, van Hoek AJ, Jit M, Edmunds WJ, Fleming D, Miller E. The burden of influenza in England by age and clinical risk group: a statistical analysis to inform vaccine policy. J Infect. 2014;68:363–371. doi: 10.1016/j.jinf.2013.11.013.
    1. Ruf BR, Knuf M. The burden of seasonal and pandemic influenza in infants and children. Eur J Pediatr. 2014;173:265–276. doi: 10.1007/s00431-013-2023-6.
    1. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, Fukuda K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003;289:179–186. doi: 10.1001/jama.289.2.179.
    1. Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, Cohen C, Gran JM, Schanzer D, Cowling BJ, Wu P, Kyncl J, Ang LW, Park M, Redlberger-Fritz M, Yu H, Espenhain L, Krishnan A, Emukule G, van Asten L, Pereira da Silva S, Aungkulanon S, Buchholz U, Widdowson M-A, Bresee JS. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet (London) 2018;391:1285–1300. doi: 10.1016/S0140-6736(17)33293-2.
    1. Brüünsgaard H, Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin N Am. 2003;23:15–39. doi: 10.1016/S0889-8561(02)00056-5.
    1. Palmer DB. The effect of age on thymic function. Front Immunol. 2013;4:316. doi: 10.3389/fimmu.2013.00316.
    1. Toapanta FR, Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res. 2009;10:112. doi: 10.1186/1465-9921-10-112.
    1. Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PAH. Cytomegalovirus seropositivity drives the cd8 t cell repertoire toward greater clonality in healthy elderly individuals. J immunol. 2002;169:1984–1992. doi: 10.4049/jimmunol.169.4.1984.
    1. Furman D, Jojic V, Sharma S, Shen-Orr SS, Angel CJL, Onengut-Gumuscu S, Kidd BA, Maecker HT, Concannon P, Dekker CL, Thomas PG, Davis MM. Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med. 2015;7:281ra43. doi: 10.1126/scitranslmed.aaa2293.
    1. Baillie JK, Bretherick A, Haley CS, Clohisey S, Gray A, Neyton LPA, Barrett J, Stahl EA, Tenesa A, Andersson R, Brown JB, Faulkner GJ, Lizio M, Schaefer U, Daub C, Itoh M, Kondo N, Lassmann T, Kawai J, Consortium I, Mole D, Bajic VB, Heutink P, Rehli M, Kawaji H, Sandelin A, Suzuki H, Satsangi J, Wells CA, Hacohen N, Freeman TC, Hayashizaki Y, Carninci P, Forrest ARR, Hume DA. Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PLOS Comput Biol. 2018;14:e1005934. doi: 10.1371/journal.pcbi.1005934.
    1. Sorensen T, Nielsen G, Andersen P, Teasdale T. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med. 1988;318:727–732. doi: 10.1056/NEJM198803243181202.
    1. Horby P, Nguyen NY, Dunstan SJ, Baillie JK. The role of host genetics in susceptibility to influenza: a systematic review. PLoS One. 2012;7:e33180. doi: 10.1371/journal.pone.0033180.
    1. Horby Peter, Nguyen Nhu Y., Dunstan Sarah J., Kenneth Baillie John. An updated systematic review of the role of host genetics in susceptibility to influenza. Influenza and Other Respiratory Viruses. 2013;7:37–41. doi: 10.1111/irv.12079.
    1. Patarčić I, Gelemanović A, Kirin M, Kolčić I, Theodoratou E, Baillie KJ, de Jong MD, Rudan I, Campbell H, Polašek O. The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis. Sci Rep. 2015;5(16119).
    1. Albright F, Orlando P, Pavia A, Jackson G, Cannon Albright L. Evidence for a heritable predisposition to death due to influenza. J Infect Dis. 2008;197:18–24. doi: 10.1086/524064.
    1. Gounder AP, Boon ACM. Influenza pathogenesis: the effect of host factors on severity of disease. J Immunol. 2019;202:341–350. doi: 10.4049/jimmunol.1801010.
    1. Ciancanelli MJ, Abel L, Zhang S-Y, Casanova J-L. Host genetics of severe influenza: from mouse mx1 to human irf7. Curr Opin Immunol. 2016;38:109–120. doi: 10.1016/j.coi.2015.12.002.
    1. Ciancanelli M. J., Huang S. X. L., Luthra P., Garner H., Itan Y., Volpi S., Lafaille F. G., Trouillet C., Schmolke M., Albrecht R. A., Israelsson E., Lim H. K., Casadio M., Hermesh T., Lorenzo L., Leung L. W., Pedergnana V., Boisson B., Okada S., Picard C., Ringuier B., Troussier F., Chaussabel D., Abel L., Pellier I., Notarangelo L. D., Garcia-Sastre A., Basler C. F., Geissmann F., Zhang S.-Y., Snoeck H.-W., Casanova J.-L. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency. Science. 2015;348(6233):448–453. doi: 10.1126/science.aaa1578.
    1. Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras M-N, Leung MC, Mathew LS, Boisson B, Zhang S-Y, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova J-L. Life-threatening influenza pneumonitis in a child with inherited irf9 deficiency. J Ex Med. 2018;215:2567–2585. doi: 10.1084/jem.20180628.
    1. Sologuren Ithaisa, Martínez-Saavedra María Teresa, Solé-Violán Jordi, de Borges de Oliveira Jr Edgar, Betancor Eva, Casas Inmaculada, Oleaga-Quintas Carmen, Martínez-Gallo Mónica, Zhang Shen-Ying, Pestano Jose, Colobran Roger, Herrera-Ramos Estefanía, Pérez Carmen, López-Rodríguez Marta, Ruiz-Hernández José Juan, Franco Nieves, Ferrer José María, Bilbao Cristina, Andújar-Sánchez Miguel, Álvarez Fernández Mercedes, Ciancanelli Michael J., Rodríguez de Castro Felipe, Casanova Jean-Laurent, Bustamante Jacinta, Rodríguez-Gallego Carlos. Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency. Journal of Clinical Immunology. 2018;38(4):513–526. doi: 10.1007/s10875-018-0512-0.
    1. Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR. A global reference for human genetic variation. Nature. 2015;526:68–74. doi: 10.1038/nature15393.
    1. Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, Manolio TA. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009;106:9362–9367. doi: 10.1073/pnas.0903103106.
    1. Brass AL, Huang I-C, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM proteins mediate cellular resistance to influenza a H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243–1254. doi: 10.1016/j.cell.2009.12.017.
    1. Desai TM, Marin M, Chin CR, Savidis G, Brass AL, Melikyan GB. IFITM3 restricts influenza a virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. PLoS Pathog. 2014;10:e1004048. doi: 10.1371/journal.ppat.1004048.
    1. Gorman MJ, Poddar S, Farzan M, Diamond MS. The interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesis. J Virol. 2016;90:8212–8225. doi: 10.1128/JVI.00581-16.
    1. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, Everingham K, Dawson H, Hope D, Ramsay P, Walsh TS, Campbell A, Kerr S, Harrison D, Rowan K, Addison J, Donald N, Galt S, Noble D, Taylor J, Webster N, Taylor I, Aldridge J, Dornan R, Richard C, Gilmour D, Simmons R, White R, Jardine C, Williams D, Booth M, Quasim T, Watson V, Henry P, Munro F, Bell L, Ruddy J, Cole S, Southward J, Allcoat P, Gray S, McDougall M, Matheson J, Whiteside J, Alcorn D, Rooney K, Sundaram R, Imrie G, Bruce J, McGuigan K, Moultrie S, Cairns C, Grant J, Hughes M, Murdoch C, Davidson A, Harris G, Paterson R, Wallis C, Binning S, Pollock M, Antonelli J, Duncan A, Gibson J, McCulloch C, Murphy L, Haley C, Faulkner G, Freeman T, Hume DA, Baillie JK, Chaussabel D, Adamson WE, Carman WF, Thompson C, Zambon MC, Aylin P, Ashby D, Barclay WS, Brett SJ, Cookson WO, Drumright LN, Dunning J, Elderfield RA, Garcia-Alvarez L, Gazzard BG, Griffiths MJ, Habibi MS, Hansel TT, Herberg JA, Holmes AH, Hussell T, Johnston SL, Kon OM, Levin M, Moffatt MF, Nadel S, Openshaw PJ, Warner JO, Aston SJ, Gordon SB, Hay A, McCauley J, O’Garra A, Banchereau J, Hayward A, Kellam P, Baillie JK, Hume DA, Simmonds P, McNamara PS, Semple MG, Smyth RL, Nguyen-Van-Tam JS, Ho L-P, McMichael AJ, Kellam P, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012;484:519–523. doi: 10.1038/nature10921.
    1. Zhang Y-H, Zhao Y, Li N, Peng Y-C, Giannoulatou E, Jin R-H, Yan H-P, Wu H, Liu J-H, Liu N, Wang D-Y, Shu Y-L, Ho L-P, Kellam P, McMichael A, Dong T. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nature Commun. 2013;4:1418. doi: 10.1038/ncomms2433.
    1. Yang X, Tan B, Zhou X, Xue J, Zhang X, Wang P, Shao C, Li Y, Li C, Xia H, Qiu J. Interferon-inducible transmembrane protein 3 genetic variant rs12252 and influenza susceptibility and severity: a meta-analysis. PloS One. 2015;10:e0124985. doi: 10.1371/journal.pone.0124985.
    1. Allen EK, Randolph AG, Bhangale T, Dogra P, Ohlson M, Oshansky CM, Zamora AE, Shannon JP, Finkelstein D, Dressen A, DeVincenzo J, Caniza M, Youngblood B, Rosenberger CM, Thomas PG. SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Nat Med. 2017;23:975–983. doi: 10.1038/nm.4370.
    1. Lucke B, Wight T, Kime E. Pathologic anatomy and bacteriology of influenza: epidemic of autumn, 1918. Arch Intern Med. 1919;24:154–237. doi: 10.1001/archinte.1919.00090250027002.
    1. Kwong JC, Schwartz KL, Campitelli MA, Chung H, Crowcroft NS, Karnauchow T, Katz K, Ko DT, McGeer AJ, McNally D, Richardson DC, Rosella LC, Simor A, Smieja M, Zahariadis G, Gubbay JB. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378:345–353. doi: 10.1056/NEJMoa1702090.
    1. Zani A, Yount JS. Antiviral protection by IFITM3 in vivo. Curr Clin Microbiol Rep. 2018;5:229–237. doi: 10.1007/s40588-018-0103-0.
    1. Zhou J, To KK, Dong H, Cheng Z-S, Lau CC-Y, Poon VKM, Fan Y-H, Song Y-Q, Tse H, Chan K-H, Zheng B-J, Zhao G-P, Yuen K-Y. A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza a virus infection. J Infect Dis. 2012;206:495–503. doi: 10.1093/infdis/jis378.
    1. Lee N, Cao B, Ke C, Lu H, Hu Y, Tam CHT, Ma RCW, Guan D, Zhu Z, Li H, Lin M, Wong RYK, Yung IMH, Hung T-N, Kwok K, Horby P, Hui DSC, Chan MCW, Chan PKS. IFITM3, TLR3, and CD55 gene SNPs and cumulative genetic risks for severe outcomes in Chinese patients with H7N9/H1N1pdm09 influenza. J Infect Dis. 2017;216:97–104. doi: 10.1093/infdis/jix235.
    1. Cheng Z, Zhou J, To KK, Chu H, Li C, Wang D, Yang D, Zheng S, Hao K, Bossé Y, Obeidat M, Brandsma C-A, Song Y-Q, Chen Y, Zheng B-J, Li L, Yuen K-Y. Identification of TMPRS22 as a susceptibility gene for severe 2009 pandemic a(H1N1) influenza and a(H7N9) influenza. J Infect Dis. 2015;212:1214–1221. doi: 10.1093/infdis/jiv246.
    1. Tarnow C, Engels G, Arendt A, Schwalm F, Sediri H, Preuss A, Nelson PS, Garten W, Klenk H-D, Gabriel G, Böttcher-Friebertshäuser E. TMPRS22 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza a virus in mice. J Virol. 2014;88:4744–4751. doi: 10.1128/JVI.03799-13.
    1. Hatesuer B, Bertram S, Mehnert N, Bahgat MM, Nelson PS, Pöhlmann S, Pöhlman S, Schughart K. TMPRS22 is essential for influenza H1N1 virus pathogenesis in mice. PLoS Pathog. 2013;9:e1003774. doi: 10.1371/journal.ppat.1003774.
    1. Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M. The host protease TMPRS22 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses. J Virol. 2014;88:5608–5616. doi: 10.1128/JVI.03677-13.
    1. To KK, Zhou J, Song Y-Q, Hung IFN, Ip WCT, Cheng Z-S, Chan ASF, Kao RYT, Wu AKL, Chau S, Luk W-K, Ip MSM, Chan K-H, Yuen K-Y. Surfactant protein b gene polymorphism is associated with severe influenza. Chest. 2014;145:1237–1243. doi: 10.1378/chest.13-1651.
    1. Li G, Siddiqui J, Hendry M, Akiyama J, Edmondson J, Brown C, Allen L, Levitt S, Poulain F, Hawgood S. Surfactant protein-a–deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza a virus. Am J Respir Cell Mol Biol. 2002;26:277–282. doi: 10.1165/ajrcmb.26.3.4584.
    1. Wood AM, Stockley RA. The genetics of chronic obstructive pulmonary disease. Respir Res. 2006;7(130).
    1. Zhou J, Wang D, Wong BH-Y, Li C, Poon VK-M, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze K-H, Chan JF-W, Chu H, To, K.K.-W, Yuen KY. Identification and characterization of GLDC as host susceptibility gene to severe influenza. EMBO Mol Med. 2019;11:e9528.
    1. Kikuchi G. The glycine cleavage system: composition, reaction mechanism, and physiological significance. Mol Cell Biochem. 1973;1:169–187. doi: 10.1007/BF01659328.
    1. Chen Y, Zhou J, Cheng Z, Yang S, Chu H, Fan Y, Li C, Wong BH-Y, Zheng S, Zhu Y, Yu F, Wang Y, Liu X, Gao H, Yu L, Tang L, Cui D, Hao K, Bossé Y, Obeidat M, Brandsma C-A, Song Y-Q, To KK, Sham PC, Yuen K-Y, Li L. Functional variants regulating LGALS1 (galectin 1) expression affect human susceptibility to influenza a(H7N9) Sci Rep. 2015;5:8517. doi: 10.1038/srep08517.
    1. To KK, Hung IFN, Li IWS, Lee K-L, Koo C-K, Yan W-W, Liu R, Ho K-Y, Chu K-H, Watt C-L, Luk W-K, Lai K-Y, Chow F-L, Mok T, Buckley T, Chan JFW, Wong SSY, Zheng B, Chen H, Lau CCY, Tse H, Cheng VCC, Chan K-H, Yuen K-Y. Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection. Clin Infect Dis. 2010;50:850–859. doi: 10.1086/650581.
    1. Liu Y, Li S, Zhang G, Nie G, Meng Z, Mao D, Chen C, Chen X, Zhou B, Zeng G. Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus. BMC Immunol. 2013;14:Article number: 37. doi: 10.1186/1471-2172-14-37.
    1. García-Ramírez RA, Ramírez-Venegas A, Quintana-Carrillo R, Camarena ÁE, Falfán-Valencia R, Mejía-Aranguré JM. TNF, IL6, and IL1B polymorphisms are associated with severe influenza A (H1N1) virus infection in the Mexican population. PloS one. 2015;10(12):e0144832. doi: 10.1371/journal.pone.0144832.
    1. Klinkhammer J, Schnepf D, Ye L, Schwaderlapp M, Gad HH, Hartmann R, Garcin D, Mahlakõiv T, Staeheli P. IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. Elife. 2018;7:e33354.
    1. Rogo LD, Rezaei F, Marashi SM, Yekaninejad MS, Naseri M, Ghavami N, Mokhtari-Azad T. Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17, and IL-28 polymorphisms in Iranian population. J Med Virol. 2016;88(12):2078–2084. doi: 10.1002/jmv.24572.
    1. Yanbaeva DG, Dentener MA, Spruit MA, Houwing-Duistermaat JJ, Kotz D, Passos VL, Wouters EF. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. BMC Med Genet. 2009;10:23. doi: 10.1186/1471-2350-10-23.
    1. Herrera-Ramos Estefanía, López-Rodríguez Marta, Ruíz-Hernández José, Horcajada Juan, Borderías Luis, Lerma Elisabeth, Blanquer José, Pérez-González María, García-Laorden María, Florido Yanira, Mas-Bosch Virginia, Montero Milagro, Ferrer José, Sorlí Luisa, Vilaplana Carlos, Rajas Olga, Briones Marisa, Aspa Javier, López-Granados Eduardo, Solé-Violán Jordi, de Castro Felipe, Rodríguez-Gallego Carlos. Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection. Critical Care. 2014;18(3):R127. doi: 10.1186/cc13934.
    1. Maestri Alvino, Sortica Vinicius Albuquerque, Tovo-Rodrigues Luciana, Santos Mirleide Cordeiro, Barbagelata Luana, Moraes Milene Raiol, Alencar de Mello Wyller, Gusmão Leonor, Sousa Rita Catarina Medeiros, Emanuel Batista dos Santos Sidney. Siaα2-3Galβ1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity. PLOS ONE. 2015;10(10):e0139681. doi: 10.1371/journal.pone.0139681.
    1. Antonopoulou A, Baziaka F, Tsaganos T, Raftogiannis M, Koutoukas P, Spyridaki A, Mouktaroudi M, Kotsaki A, Savva A, Georgitsi M. Giamarellos-Bourboulis. EJ Int J Infect Dis. 2012;16(3):e204–e208. doi: 10.1016/j.ijid.2011.11.012.
    1. Esposito S, Molteni CG, Giliani S, Mazza C, Scala A, Tagliaferri L, Pelucchi C, Fossali E, Plebani A, Principi N. Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children. Virol J. 2012;9:270. doi: 10.1186/1743-422X-9-270.

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