Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case-Control Study With Electroencephalogram

Tianran Zhang, Lanlan Wang, Yanle Bai, Wenqing Zhao, Yanru Wu, Wenhui Jiang, Qing Fan, Jianyin Qiu, Tianran Zhang, Lanlan Wang, Yanle Bai, Wenqing Zhao, Yanru Wu, Wenhui Jiang, Qing Fan, Jianyin Qiu

Abstract

Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case-control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls. Design: Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32). Discussion: The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism. Trial Registration: NCT03558256. Registered: June 13, 2018-retrospectively registered, https://ichgcp.net/clinical-trials-registry/NCT03558256.

Keywords: case-control study; electroencephalogram; major depressive disorder; mindfulness based cognitive therapy; randomized-control trial.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Zhang, Wang, Bai, Zhao, Wu, Jiang, Fan and Qiu.

Figures

Figure 1
Figure 1
Study design and measurement time points. EEG, electroencephalogram; HAMD24, Hamilton Depression Scale-24; HAMA, Hamilton Anxiety Scale; SCS, Self-Compassion Scale; BDI-II, Beck Depression Inventory-II; SAS, Self-rating Anxiety Scale; EES, Emotional Expressivity Scale; IRI, Interpersonal Reactivity Index; TAS, Toronto Alexithymia Scale; TEPS, Temporal Experience of Pleasure Scale; ERQ, Emotion Regulation Questionnaire; PANAS, Positive Affect and Negative Affect Scale, CERQ, Cognitive Emotion Regulation Questionnaire.

References

    1. Kessler RC, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ormel J, et al. . The global burden of mental disorders: an update from the WHO World Mental Health (WMH) Surveys. Epidemiol Psich Soc. (2009) 18:23–33. 10.1017/S1121189X00001421
    1. World Health Organization . Depression Fact Sheet. (2012). Retrieved from:
    1. Kessing LV, Hansen MG, Kessing LV, Hansen GM, Andersen G, Angst J. The predictive effect of episodes on the risk of recurrence in depressive and bipolar disorders—A life-long perspective. Acta Psychiatr Scand. (2004) 109:339–44. 10.1046/j.1600-0447.2003.00266.x
    1. Bloom FE, Kupfer DJ, Bunney BS. Psychopharmacology: the Fourth Generation of Progress. New York, NY: Raven Press; (1995).
    1. Pigott HE, Leventhal AM, Alter GS, Boren JJ. Efficacy and effectiveness of antidepressants: current status of research. Psychother Psych. (2010) 79:267–79. 10.1159/000318293
    1. Segal ZV, Williams JMG, Teasdale JD. Mindfulness-Based Cognitive Therapy for Depression: A New Approach to Preventing Relapse. New York, NY: Guilford Press; (2002).
    1. Kabat-Zinn J. Mindfulness-based interventions in context: past, present, and future. Clin Psych Sci Practice. (2003) 10:144–56. 10.1093/clipsy.bpg016
    1. Lau MA, Segal ZV, Williams JMG. Teasdale's differential activation hypothesis: implications for mechanisms of depressive relapse and suicidal behaviour. Behav Res Ther. (2004) 42:1001–17. 10.1016/j.brat.2004.03.003
    1. Zhang Z, Zhang L, Zhang G, Jin J, Zheng Z. The effect of cbt and its modifications for relapse prevention in major depressive disorder: a systematic review and meta-analysis. BMC Psychiatry. (2018) 18:50. 10.1186/s12888-018-1610-5
    1. Piet J, Hougaard E. The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis. Clin Psych Rev. (2011) 31:1032–40. 10.1016/j.cpr.2011.05.002
    1. Godfrin KA, Van Heeringen C. The effects of mindfulness-based cognitive therapy on recurrence of depressive episodes, mental health and quality of life: a randomized controlled study. Behav Res Ther. (2010) 48:738–46. 10.1016/j.brat.2010.04.006
    1. Manicavasgar V, Parker G, Perich T. Mindfulness-based cognitive therapy vs cognitive behaviour therapy as a treatment for non-melancholic depression. J Affect Disord. (2011) 130:138–144. 10.1016/j.jad.2010.09.027
    1. Kenny MA, Williams JMG. Treatment-resistant depressed patients show a good response to mindfulness-based cognitive therapy. Behav Res Ther. (2007) 45:617–25. 10.1016/j.brat.2006.04.008
    1. Eisendrath SJ, Delucchi K, Bitner R, Fenimore P, Smit M, McLane M. Mindfulness-based cognitive therapy for treatment-resistant depression: a pilot study. Psychother Psychos. (2008) 77:319–20. 10.1159/000142525
    1. Crane C, Barnhofer T, Duggan DS, Hepburn S, Fennell MV, Williams JMG. Mindfulness-based cognitive therapy and self-discrepancy in recovered depressed patients with a history of depression and suicidality. Cogn Therap Res. (2008) 32:775. 10.1007/s10608-008-9193-y
    1. Kingston T, Dooley B, Bates A, Lawlor E, Malone K. Mindfulness-based cognitive therapy for residual depressive symptoms. Psych Psychother Theory Res Pract. (2007) 80:193–203. 10.1348/147608306X116016
    1. Slagter HA, Lutz A, Greischar LL, Francis AD, Nieuwenhuis S, Davis JM, et al. . Mental training affects distribution of limited brain resources. PLoS Biol. (2012) 5:e138. 10.1371/journal.pbio.0050138
    1. Rimma T, Michael I. Meditation, mindfulness and executive control: the importance of emotional acceptance and brain-based performance monitoring. Soc Cogn Affect Neurosci. (2013) 8:85–92. 10.1093/scan/nss045
    1. Procyshyn RM, Bezchlibnyk-Butler KZ, Jeffries JJ. (Eds.). Clinical Handbook of Psychotropic Drugs. Cambridge: Hogrefe Publishing. (2017). 10.1027/00496-000
    1. Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K. Severity classification on the hamilton depression rating scale. J Affect Disorder. (2013) 150:384–8. 10.1016/j.jad.2013.04.028
    1. Zimmerman M, Martin J, Clark H, McGonigal P, Harris L, Holst CG. Measuring anxiety in depressed patients: a comparison of the Hamilton anxiety rating scale and the DSM-5 Anxious Distress Specifier Interview. J Psychiatr Res. (2017) 93:59–63. 10.1016/j.jpsychires.2017.05.014
    1. Neff KD. The development and validation of a scale to measure self-compassion. Self Identity. (2003) 2:223–50. 10.1080/15298860309027
    1. Chan RC, Wang Y, Li H, Shi Y, Wang Y, Liu W, et al. . A 2-stage factor analysis of the Emotional Expressivity Scale in the Chinese context. Psychologia. (2010) 53:44–50. 10.2117/psysoc.2010.44
    1. Zhu X, Yi J, Yao S, Ryder AG, Taylor GJ, Bagby RM. Cross-cultural validation of a Chinese translation of the 20-item Toronto Alexithymia Scale. Compreh Psych. (2007) 48:489–96. 10.1016/j.comppsych.2007.04.007
    1. Chan RC, Shi YF, Lai MK, Wang YN, Wang Y, Kring AM. The Temporal Experience of Pleasure Scale (TEPS): exploration and confirmation of factor structure in a healthy Chinese sample. PLoS ONE. (2012) 7:e35352. 10.1371/journal.pone.0035352
    1. Li WANG., Hengchao LIU, Zhongquan L. Reliability and validity of emotion regulation questionnaire Chinese revised version. Chin J Health Psychol. (2007) 6:013. 10.3969/j.issn.1005-1252.2007.06.034
    1. Zhu X, Auerbach RP, Yao S, Abela JR, Xiao J, Tong X. Psychometric properties of the cognitive emotion regulation questionnaire: chinese version. Cogn Emot. (2008) 22:288–07. 10.1080/02699930701369035

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