Airway cells from atopic asthmatic patients exposed to ozone display an enhanced innate immune gene profile
Michelle Hernandez, Willie June Brickey, Neil E Alexis, Rebecca C Fry, Julia E Rager, Baiming Zhou, Jenny P Y Ting, Haibo Zhou, David B Peden, Michelle Hernandez, Willie June Brickey, Neil E Alexis, Rebecca C Fry, Julia E Rager, Baiming Zhou, Jenny P Y Ting, Haibo Zhou, David B Peden
Abstract
This study identifies transcriptional phenotypes of sputum samples from normal volunteers and atopic asthmatics exposed to ozone. Network analyses suggest that asthmatics elevate immune signaling following oxidative stress, while nonasthmatics attempt to mitigate the ozone-induced response.
Figures
A) Heat map of O3-modulated genes in NV and AA with low (blue) and high (red) expression. B) Changes with O3 in PCR-amplified ERBB2 pathway, oxidant response and innate immune transcripts relative to ACTB (n=6 NV, 8 AA). Mean changes in gene expression with O3 (± SEM). Nonparametric t testing (Mann Whitney testing) was used to compare differences in NV and AA.
Source: PubMed