Frequent ice cream consumption is associated with reduced striatal response to receipt of an ice cream-based milkshake

Abstract

Background: Weight gain leads to reduced reward-region responsivity to energy-dense food receipt, and consumption of an energy-dense diet compared with an isocaloric, low-energy-density diet leads to reduced dopamine receptors. Furthermore, phasic dopamine signaling to palatable food receipt decreases after repeated intake of that food, which collectively suggests that frequent intake of an energy-dense food may reduce striatal response to receipt of that food.

Objective: We tested the hypothesis that frequent ice cream consumption would be associated with reduced activation in reward-related brain regions (eg, striatum) in response to receipt of an ice cream-based milkshake and examined the influence of adipose tissue and the specificity of this relation.

Design: Healthy-weight adolescents (n = 151) underwent fMRI during receipt of a milkshake and during receipt of a tasteless solution. Percentage body fat, reported food intake, and food craving and liking were assessed.

Results: Milkshake receipt robustly activated the striatal regions, yet frequent ice cream consumption was associated with a reduced response to milkshake receipt in these reward-related brain regions. Percentage body fat, total energy intake, percentage of energy from fat and sugar, and intake of other energy-dense foods were not related to the neural response to milkshake receipt.

Conclusions: Our results provide novel evidence that frequent consumption of ice cream, independent of body fat, is related to a reduction in reward-region responsivity in humans, paralleling the tolerance observed in drug addiction. Data also imply that intake of a particular energy-dense food results in attenuated reward-region responsivity specifically to that food, which suggests that sensory aspects of eating and reward learning may drive the specificity.

Figures

FIGURE 1.

A and B: Widespread activation in response to milkshake receipt (milkshake receipt > tasteless solution receipt contrast) in the bilateral putamen (circles; A) and the bilateral caudate (circles; B) and oral somatosensory regions (squares; see Table S1 and Figure S1 under “Supplemental data” in the online issue for additional details). C and D: Reduced striatal responsivity to milkshake receipt as a function of frequency of ice cream consumption (tasteless solution receipt > milkshake receipt contrast). Participants’ frequency of ice cream intake was associated with reduced responsivity to milkshake receipt in the bilateral putamen (A) and right caudate (B). Additional details are presented in Table 1. Both the axial (upper left) and coronal (lower right) views are presented, and color bars indicate the T value of the activation.

FIGURE 2.

Striatal responsivity to milkshake receipt as a function of ice cream consumption. Frequency of ice cream consumption relations to the average cluster parameter estimates of the right putamen (A), left putamen (B), and left caudate (C).