Relation between stress and cytokine responses in inner-city mothers
David A Gruenberg, Rosalind J Wright, Cynthia M Visness, Katy F Jaffee, Gordon R Bloomberg, William W Cruikshank, Meyer Kattan, Megan T Sandel, Robert A Wood, James E Gern, David A Gruenberg, Rosalind J Wright, Cynthia M Visness, Katy F Jaffee, Gordon R Bloomberg, William W Cruikshank, Meyer Kattan, Megan T Sandel, Robert A Wood, James E Gern
Abstract
Background: Women in poor urban neighborhoods have high rates of stress and allergic diseases, but whether stress or stress correlates such as depression promote inflammatory and type 2 cytokine responses is unknown.
Objective: To examine associations among external stressors, perceived stress, depression, and peripheral blood mononuclear cell cytokine responses of mothers enrolled in the Urban Environment and Childhood Asthma Study and test the hypothesis that stress would be positively associated with type 2 and selected proinflammatory (tumor necrosis factor-α and interleukin-8) responses.
Methods: Questionnaire data from mothers living in 4 inner cities included information about external stress, stress perception, and depression. The external stress domains (interpersonal problems, housing, and neighborhood stress) were combined into a Composite Stressor score. Peripheral blood mononuclear cells were stimulated ex vivo and cytokine responses to innate, adaptive, and polyclonal immune stimuli were compared with stress and depression scores for 469 of the 606 study participants.
Results: There were no significant positive associations between Composite Stressor scores, perceived stress, or depression scores and proinflammatory or type 2 cytokine responses, and these findings were not modified by allergy or asthma status. There were some modest associations with individual stressors and cytokine responses, but no consistent relations were noted. Depression was associated with decreased responses to some stimuli, particularly dust mite.
Conclusion: Composite measurements of stressors, perceived stress, or depression were not positively related to proinflammatory or type 2 cytokine responses in these young urban women. These data do not support the hypothesis that these factors promote cytokine responses associated with allergy.
Trial registration: ClinicalTrials.gov, identifier NCT00114881.
Copyright © 2015. Published by Elsevier Inc.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4814156/bin/nihms759847f1.jpg)
Figure 2
Associations between depression/perceived stress and…
Figure 2
Associations between depression/perceived stress and cytokine responses to innate (A) and adaptive (B)…
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- Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort.Wright RJ, Visness CM, Calatroni A, Grayson MH, Gold DR, Sandel MT, Lee-Parritz A, Wood RA, Kattan M, Bloomberg GR, Burger M, Togias A, Witter FR, Sperling RS, Sadovsky Y, Gern JE. Wright RJ, et al. Am J Respir Crit Care Med. 2010 Jul 1;182(1):25-33. doi: 10.1164/rccm.200904-0637OC. Epub 2010 Mar 1. Am J Respir Crit Care Med. 2010. PMID: 20194818 Free PMC article.
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- Clinical Trial
- Research Support, N.I.H., Extramural
- Adolescent
- Adult
- Asthma / immunology
- Cytokines / immunology*
- Depression / immunology
- Female
- Humans
- Hypersensitivity / immunology
- Interleukin-8 / immunology*
- Leukocytes, Mononuclear / immunology
- Mothers
- Residence Characteristics
- Stress, Psychological / immunology*
- Tumor Necrosis Factor-alpha / immunology*
- Urban Population
- Young Adult
- CXCL8 protein, human
- Cytokines
- Interleukin-8
- TNF protein, human
- Tumor Necrosis Factor-alpha
- ClinicalTrials.gov/NCT00114881
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Source: PubMed