Fasting-mimicking diet plus chemotherapy in breast cancer treatment

Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de Braud, Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de Braud

Abstract

A clinical trial published in Nature Communications examined the effect of fasting-mimicking diet (FMD) during chemotherapy in breast cancer patients. The overall negative study results highlight the need for ameliorating future trial design and investigating alternative FMD-based therapeutic combinations.

Conflict of interest statement

C.V., L.R. and F.deB. were inventors of an FMD regimen that is being evaluated in the context of ongoing clinical trials in cancer patients.

References

    1. de Groot S, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat. Commun. 2020;11:3083. doi: 10.1038/s41467-020-16138-3.
    1. Di Biase S, et al. Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer Cell. 2016;30:136–146. doi: 10.1016/j.ccell.2016.06.005.
    1. Caffa I, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020;583:620–624. doi: 10.1038/s41586-020-2502-7.
    1. Brandhorst S, et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab. 2015;22:86–99. doi: 10.1016/j.cmet.2015.05.012.
    1. Raffaghello L, et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc. Natl Acad. Sci. USA. 2008;105:8215–8220. doi: 10.1073/pnas.0708100105.
    1. Cortazar P, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet. 2014;384:164–172. doi: 10.1016/S0140-6736(13)62422-8.
    1. Romero A, et al. Correlation between response to neoadjuvant chemotherapy and survival in locally advanced breast cancer patients. Ann. Oncol. 2013;24:655–661. doi: 10.1093/annonc/mds493.
    1. Guerin, M. V., et al. Preclinical murine tumor models: a structural and functional perspective. Elife9, 10.7554/eLife.50740 (2020).
    1. Choi M, et al. Assessment of pathologic response and long-term outcome in locally advanced breast cancers after neoadjuvant chemotherapy: comparison of pathologic classification systems. Breast Cancer Res Treat. 2016;160:475–489. doi: 10.1007/s10549-016-4008-4.
    1. Bauersfeld SP, et al. The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study. BMC Cancer. 2018;18:476. doi: 10.1186/s12885-018-4353-2.
    1. Cheryl L. et al. American Cancer Society guideline for diet and physical activity for cancer prevention ACS journal. 10.3322/caac.21591 (2020).
    1. Obradovic MMS, et al. Glucocorticoids promote breast cancer metastasis. Nature. 2019;567:540–544. doi: 10.1038/s41586-019-1019-4.
    1. Giles AJ, et al. Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy. J. Immunother. Cancer. 2018;6:51. doi: 10.1186/s40425-018-0371-5.
    1. Elgendy M, et al. Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3beta-MCL-1 Axis. Cancer Cell. 2019;35:798–815 e795. doi: 10.1016/j.ccell.2019.03.007.

Source: PubMed

Sponsors et collaborateurs

Les conditions médicales

Interventions en matière de drogue

3
S'abonner