Circulating IL-6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID-19
Vanessa Granger, Audrey Fels, Thomas Huet, Jean-Louis Laplanche, Sophie Laplanche, Gilles Chatellier, Hélène Beaussier, Sylvie Chollet-Martin, Luc de Chaisemartin, Gilles Hayem, Vanessa Granger, Audrey Fels, Thomas Huet, Jean-Louis Laplanche, Sophie Laplanche, Gilles Chatellier, Hélène Beaussier, Sylvie Chollet-Martin, Luc de Chaisemartin, Gilles Hayem
Abstract
Added data on circulating IL-6 levels can predict COVID-19 severity and IL1RA efficiency.
Conflict of interest statement
The authors declare no conflict of interest.
©2022 Society for Leukocyte Biology.
Figures
Kaplan–Meier cumulative estimation of probability of survival according to IL‐6 (A) or NET (B) levels at Day 0 and log‐rank test. The median values of IL‐6 levels (75.49 pg/ml) and NET levels (58.39 au) are used for the analysis
IL‐6 circulating levels before (Day 0) and after 3–4 days of anakinra (D3/4). The horizontal bars represent the median values (n = 32). *p = 0.012 as compared to Day 0 values
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Source: PubMed