Exercise and sport performance with low doses of caffeine

Lawrence L Spriet, Lawrence L Spriet

Abstract

Caffeine is a popular work-enhancing supplement that has been actively researched since the 1970s. The majority of research has examined the effects of moderate to high caffeine doses (5-13 mg/kg body mass) on exercise and sport. These caffeine doses have profound effects on the responses to exercise at the whole-body level and are associated with variable results and some undesirable side effects. Low doses of caffeine (<3 mg/kg body mass, ~200 mg) are also ergogenic in some exercise and sport situations, although this has been less well studied. Lower caffeine doses (1) do not alter the peripheral whole-body responses to exercise; (2) improve vigilance, alertness, and mood and cognitive processes during and after exercise; and (3) are associated with few, if any, side effects. Therefore, the ergogenic effect of low caffeine doses appears to result from alterations in the central nervous system. However, several aspects of consuming low doses of caffeine remain unresolved and suffer from a paucity of research, including the potential effects on high-intensity sprint and burst activities. The responses to low doses of caffeine are also variable and athletes need to determine whether the ingestion of ~200 mg of caffeine before and/or during training and competitions is ergogenic on an individual basis.

Figures

Fig. 1
Fig. 1
Plasma caffeine concentrations for 1 h at rest and during exercise to exhaustion at 80–85 % of maximum oxygen uptake in recreationally active subjects after the consumption of a placebo (open circles), or 3 (filled squares), 6 (filled triangles) or 9 (filled circles) mg/kg body mass of caffeine. Data are means ± standard error (n = 8). exh exhaustion (reproduced from Graham and Spriet [2], with permission)
Fig. 2
Fig. 2
Effects of ingesting no caffeine (0) or 3, 6 or 9 mg/kg body mass of caffeine (dose) on running time to exhaustion at ~85 % of maximum oxygen uptake. Data are means ± standard error (n = 8). Barswith different letters are significantly different, and bars with the same letters are not significantly different (reproduced from Graham and Spriet [2], with permission)

References

    1. Pasman WJ, VanBaak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med. 1995;16:225–230. doi: 10.1055/s-2007-972996.
    1. Graham TE, Spriet LL. Metabolic, catecholamine and exercise performance responses to varying doses of caffeine. J Appl Physiol. 1995;78:867–874.
    1. Spriet LL, MacLean DA, Dyck DJ, et al. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992;262:E891–E898.
    1. Graham TE, Spriet LL. Performance and metabolic responses to a high caffeine dose during prolonged exercise. J Appl Physiol. 1991;71:2292–2298.
    1. Graham TE, Helge JW, MacLean DA, et al. Caffeine ingestion does not alter carbohydrate or fat metabolism in skeletal muscle during exercise. J Physiol. 2000;529(3):837–847. doi: 10.1111/j.1469-7793.2000.00837.x.
    1. Graham TE, Rush JWE, van Soeren MH. Caffeine and exercise: metabolism and performance. Can J Appl Physiol. 1994;19:111–138. doi: 10.1139/h94-010.
    1. Spriet LL. Caffeine. In: Bahrke MS, Yesalis CE, editors. Performance enhancing substances in sport and exercise. Windsor: Human Kinetics; 2003. pp. 267–278.
    1. Spriet LL. Caffeine. In: Maughan RJ, ed. The encyclopaedia of sports medicine: an IOC medical commission publication. Sports Nutrition. Vol 19. Oxford: Wiley; 2013. p. 313–23.
    1. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic, and psychostimulant effects. Brain Res Rev. 1992;17:139–170. doi: 10.1016/0165-0173(92)90012-B.
    1. Daly JW. Mechanism of action of caffeine. In: Garatttini S, editor. Caffeine, coffee, and health. New York: Raven Press; 1993. pp. 97–150.
    1. Fredholm BB. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol. 1995;76:93–101. doi: 10.1111/j.1600-0773.1995.tb00111.x.
    1. Kalmar JM, Cafarelli E. Caffeine: a valuable tool to study central fatigue in humans. Exerc Sports Sci Rev. 2004;32:143–147. doi: 10.1097/00003677-200410000-00004.
    1. Davis JM, Zhao Z, Stock HS, et al. Central nervous system effects of caffeine and adenosine on fatigue. Am J Physiol. 2003;284:R399–R404.
    1. Graham TE, Hibbert E, Sathasivam P. Metabolic and exercise endurance effects of coffee and caffeine ingestion. J Appl Physiol. 1998;85:883–889.
    1. Hodgson AB, Randell RK, Jeukendup AE. The metabolic and performance effects of caffeine compared to coffee during endurance exercise. PLoS One. 2013;8:e59561. doi: 10.1371/journal.pone.0059561.
    1. Kamimori GH, Karyekar CS, Otterstetter R, et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm. 2002;234:159–167. doi: 10.1016/S0378-5173(01)00958-9.
    1. Costill DL, Dalsky GP, Fink WJ. Effects of caffeine on metabolism and exercise performance. Med Sci Sports. 1978;10:155–158.
    1. Ivy JL, Costill DL, Fink WJ, et al. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports. 1979;11:6–11. doi: 10.2165/00007256-199111010-00002.
    1. Kovacs EMR, Stegen JHCH, Brouns F. Effect of caffeine drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol. 1998;85:709–715.
    1. Cox GR, Desbrow B, Montgomery PG, et al. Effect of different protocols of caffeine intake on metabolism and performance. J Appl Physiol. 2002;93:990–999.
    1. Talanian JL, Spriet LL. Low doses of caffeine late in exercise improve cycling time trial performance. FASEB J. 2007;21:107.
    1. Jenkins NT, Trilk JL, Singhal A, et al. Ergogenic effects of low doses of caffeine on cycling performance. Int J Sport Nutr Exerc Metab. 2008;18:328–342.
    1. Desbrow B, Barrett CM, Minahan CL, et al. Caffeine, cycling performance, and exogenous CHO oxidation: a dose-response study. Med Sci Sports Exerc. 2009;41:1744–1751. doi: 10.1249/MSS.0b013e3181a16cf7.
    1. Irwin C, Desbrow B, Ellis A, et al. Caffeine withdrawal and high-intensity endurance cycling performance. J Sports Sci. 2011;29:509–515. doi: 10.1080/02640414.2010.541480.
    1. Desbrow B, Biddulph C, Devlin B, et al. The effects of different doses of caffeine on endurance cycling time trial performance. J Sports Sci. 2012;3:115–120. doi: 10.1080/02640414.2011.632431.
    1. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008;33:1319–1334. doi: 10.1139/H08-130.
    1. Ganio MS, Klau JF, Casa DJ, et al. Effect of caffeine on sport-specific endurance performance: a systematic review. J Strength Cond Res. 2009;23:315–324. doi: 10.1519/JSC.0b013e31818b979a.
    1. Wiles JD, Bird SR, Hopkins J, et al. Effect of caffeinated coffee on running speed, respiratory factors, blood lactate and perceived exertion during 1,500 m treadmill running. Br J Sports Med. 1992;26:116–120. doi: 10.1136/bjsm.26.2.116.
    1. Van Nieuwenhoven MA, Brouns F, Kovacs EM. The effect of two sports drinks and water on GI complaints and performance during an 18 km run. Int J Sports Med. 2005;26:281–285. doi: 10.1055/s-2004-820931.
    1. Bridge CA, Jones MA. The effect of caffeine ingestion on 8 km run performance in a field setting. J Sports Sci. 2006;24:433–439. doi: 10.1080/02640410500231496.
    1. Schubert MM, Astorino TA, Azevedo JL., Jr The effects of caffeinated “energy shots” on time trial performance. Nutrients. 2013;6:2062–2075. doi: 10.3390/nu5062062.
    1. Strecker E, Foster EB, Taylor K, et al. Effects of caffeine ingestion on tennis skill performance and hydration status [abstract] Med Sci Sports Exerc. 2007;39:S43. doi: 10.1249/01.mss.0000273312.37308.85.
    1. Stevenson EJ, Hayes PR, Allison SJ. The effect of a carbohydrate-caffeine sports drink on simulated golf performance. Appl Physiol Nutr Metab. 2009;34:681–688. doi: 10.1139/H09-057.
    1. Perez-Lopez A, Salinero JJ, Abian-Vicen J, et al. Caffeinated energy drinks improve volleyball performance in elite female players. Med Sci Sports Exerc. Epub 18 Jul 2014.
    1. Del Coso J, Pereze-Lopez A, Abian-Vican L, et al. Caffeine-containing energy drink enhances physical performance in male volleyball players. Int J Sports Physiol Perform. Epub 19 Mar 2014.
    1. Gant N, Ali A, Foskett A. The influence of caffeine and carbohydrate coingestion on simulated soccer performance. Int J Sports Nutr Exerc Metab. 2010;20:191–197.
    1. Roberts SP, Stokes KA, Trewartha G, et al. Effects of carbohydrate and caffeine ingestion on performance during a rugby union simulation protocol. J Sports Sci. 2010;28:833–842. doi: 10.1080/02640414.2010.484069.
    1. Spriet LL. Anaerobic metabolism during exercise. In: Hargreaves M, Spriet LL, editors. Exercise metabolism. 2. Windsor: Human Kinetics; 2006. pp. 7–28.
    1. Parolin ML, Chesley A, Matsos MP, et al. Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. Am J Physiol Endocrinol Metab. 1999;277:E890–E900.
    1. Astorino TA, Robertson DW. Efficacy of acute caffeine ingestion for short-term high intensity exercise performance: a systematic review. J Strength Cond Res. 2010;24:257–265. doi: 10.1519/JSC.0b013e3181c1f88a.
    1. Davis JK, Green JM. Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med. 2009;39:813–832. doi: 10.2165/11317770-000000000-00000.
    1. Jacobson BH, Weber MD, Claypool L. Effect of caffeine on maximal strength and power in elite male athletes. Br J Sports Med. 1992;26:276–280. doi: 10.1136/bjsm.26.4.276.
    1. Woolf K, Bidwell W, Carlson AG. The effect of caffeine as an ergogenic aid in anaerobic exercise. Int J Sport Nutr Exerc Metab. 2008;18:412–429.
    1. Wiles JD, Coleman D, Tegerdine M, et al. The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1-km cycling time trial. J Sports Sci. 2006;24:1165–1171. doi: 10.1080/02640410500457687.
    1. Doherty M, Smith P, Hughes M, et al. Caffeine lowers perceptual response and increases power output during high-intensity cycling. J Sports Sci. 2004;22:637–643. doi: 10.1080/02640410310001655741.
    1. Anselme F, Collomp K, Mercier B, et al. Caffeine increases maximal anaerobic power and blood lactate concentration. Eur J Appl Occup Physiol. 1992;65:188–191. doi: 10.1007/BF00705079.
    1. Collomp K, Ahmaidi S, Chatard JC, et al. Benefits of caffeine ingestion on sprint performance in trained and untrained swimmers. Eur J Appl Occup Physiol. 1992;64:377–380. doi: 10.1007/BF00636227.
    1. Astorino TA, Terzi MN, Roberson DW, et al. Effect of two doses of caffeine on muscular function during isokinetic exercise. Med Sci Sports Exerc. 2010;42:2205–2210. doi: 10.1249/MSS.0b013e3181e3a11d.
    1. Lieberman HR, Wurtman RJ, Emde GG, et al. The effects of low doses of caffeine on human performance and mood. Psychopharmacology. 1987;92:308–312. doi: 10.1007/BF00210835.
    1. Olson CA, Thornton JA, Adam GE, et al. Effects of adenosine antagonists, quercitin and caffeine, on vigilance and mood. J Clin Pyschopharmacol. 2010;30:573–578. doi: 10.1097/JCP.0b013e3181ee0f79.
    1. Brunye TT, Mahoney CR, Lieberman HR, et al. Caffeine modulates attention network function. Brain Cogn. 2010;72:181–188. doi: 10.1016/j.bandc.2009.07.013.
    1. Hogervorst E, Riedel WJ, Kovacs E, et al. Caffeine improves cognitive performance after strenuous physical exercise. Int J Sports Med. 1999;20:354–361. doi: 10.1055/s-2007-971144.
    1. Hogervorst E, Badelow S, Scmitt J, et al. Caffeine improves physical and cognitive performance during exhaustive exercise. Med Sci Sports Exerc. 2008;40:1842–1851. doi: 10.1249/MSS.0b013e31817bb8b7.
    1. Motl RW, OConnor PJ, Dishman RK. Effect of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise. J Pain. 2003;4:316–321. doi: 10.1016/S1526-5900(03)00635-7.
    1. Motl RW, OConnor PJ, Tubandt L, et al. Effect of caffeine on leg muscle pain during cycling exercise among females. Med Sci Sports Exerc. 2006;38:598–604. doi: 10.1249/01.mss.0000193558.70995.03.
    1. Gliottoni RC, Meyers JR, Arngrimsson SA, et al. Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. Int J Sport Nutr Exerc Metab. 2009;19:150–161.
    1. Astorino TA, Terzi MN, Roberson DW. Effect of caffeine intake on pain perception during high intensity exercise. Int J Sport Nutr Exerc Metab. 2011;21:27–32.
    1. Ganio MS, Johnson EC, Lopez RM, et al. Caffeine lowers muscle pain during exercise in hot but not cool environments. Physiol Behav. 2011;102:429–435. doi: 10.1016/j.physbeh.2010.12.005.
    1. Cohen BS, Nelson AG, Prevost MC, et al. Effects of caffeine ingestion on endurance racing in the heat and humidity. Eur J Appl Occup Physiol. 1996;73:358–363. doi: 10.1007/BF02425499.
    1. Roelands B, Buyse L, Pauwels F, et al. No effect of caffeine on exercise performance in high ambient temperature. Eur J Appl Physiol. 2011;111:3089–3095. doi: 10.1007/s00421-011-1945-9.
    1. Ganio MS, Johnson EC, Klau JF, et al. Effect of ambient temperature on caffeine ergogenicity during endurance exercise. Eur J Appl Physiol. 2011;111:1135–1146. doi: 10.1007/s00421-010-1734-x.
    1. Van Nieuwenhoven MA, Brummer RJM, Brouns F. Gastrointestinal function during exercise: comparison of water, sports drink, and sports drink with caffeine. J Appl Physiol. 2000;89:1079–1085.
    1. Yeo SE, Jentjens RLPG, Wallis GA, et al. Caffeine increases exogenous carbohydrate oxidation during exercise. J Appl Physiol. 2005;99:844–850. doi: 10.1152/japplphysiol.00170.2005.
    1. Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc. 2008;40:2096–2104. doi: 10.1249/MSS.0b013e318182a9c7.
    1. Andoniou CE, Andrews DM, Degli-Esposti MA. Natural killer cells in viral infection: more than just killers. Immunol Rev. 2006;214:239–250. doi: 10.1111/j.1600-065X.2006.00465.x.
    1. Gleeson M. Immune function in sport and exercise. J Appl Physiol. 2007;103:693–699. doi: 10.1152/japplphysiol.00008.2007.
    1. Fletcher DK, Bishop NC. Effect of high and low dose of caffeine on antigen-stimulated activation of human natural killer cells after prolonged exercise. Int J Sport Nutr Exerc Metab. 2011;21:155–165.
    1. Syed SA, Kamimori GH, Kelly W, et al. Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers. Biopharm Drug Dispos. 2005;26:403–409. doi: 10.1002/bdd.469.
    1. Ryan EJ, Kim CH, Muller MD, et al. Low-dose caffeine administered in chewing gum does not enhance cycling to exhaustion. J Strength Cond Res. 2012;26:844–850.
    1. Ryan EJ, Kim CH, Fickes EJ, et al. Caffeine gum and cycling performance: a timing study. J Strength Cond Res. 2013;27:259–264. doi: 10.1519/JSC.0b013e3182541d03.
    1. Paton CD, Lowe T, Irvine A. Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. Eur J Appl Physiol. 2010;110:1243–1250. doi: 10.1007/s00421-010-1620-6.
    1. Bellar D, Kamimori G, Judge L. Effects of low-dose caffeine supplementation on early morning performance in the standing shot put throw. Eur J Sports Sci. 2012;12:57–61. doi: 10.1080/17461391.2010.536585.
    1. Doering TM, Fell JW, Veveritt MD, et al. The effect of a caffeinated mouth-rinse on endurance cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2014;24:90–97. doi: 10.1123/ijsnem.2013-0103.
    1. Beaven CM, Maulder P, Pooley A, et al. Effects of caffeine and carbohydrate mouth rinses on repeated sprint performance. Appl Physiol Nutr Metab. 2013;38:633–637. doi: 10.1139/apnm-2012-0333.

Source: PubMed

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