The higher plasma malondialdehyde concentrations are determined by metabolic syndrome-related glucolipotoxicity

Fernando Moreto, Erick P de Oliveira, Rodrigo M Manda, Roberto C Burini, Fernando Moreto, Erick P de Oliveira, Rodrigo M Manda, Roberto C Burini

Abstract

This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), γ-glutamyltransferase (γ-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and γ-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.

Figures

Figure 1
Figure 1
Logistic regression analysis identifying the main predictors for higher plasma MDA concentrations; (a) metabolic syndrome and its components; (b) anthropometry, body composition, and fitness; (c) dietary intake; (d) blood markers. Analyses were adjusted for age, gender, smoking status, medicine use, BMI, and energy intake. Black circles are odds ratio and traces are confidence interval. *P < 0.05.

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