Vaccination and allergic disease: a birth cohort study

Tricia M McKeever, Sarah A Lewis, Chris Smith, Richard Hubbard, Tricia M McKeever, Sarah A Lewis, Chris Smith, Richard Hubbard

Abstract

Objectives: We examined the effect of vaccination for diphtheria; polio; pertussis and tetanus; or measles, mumps, and rubella on the incidence of physician-diagnosed asthma and eczema.

Methods: We used a previously established birth cohort in the West Midlands General Practice research database.

Results: We found an association between vaccination and the development of allergic disease; however, this association was present only among children with the fewest physician visits and can be explained by this factor.

Conclusions: Our data suggest that currently recommended routine vaccinations are not a risk factor for asthma or eczema.

References

    1. Chadwick DJ, Cardew G. The Rising Trends in Asthma. Chichester, England: John Wiley & Sons; 1997.
    1. Sen DK, Arora S, Gupta S, Sanyal RK. Studies of adrenergic mechanisms in relation to histamine sensitivity in children immunized with Bordetella pertussis vaccine. J Allergy Clin Immunol. 1974;54:25–31.
    1. Odelram H, Granstrom M, Hedenskog S, Duchen K, Bjorksten B. Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminium content of the vaccines. Pediatr Allergy Immunol. 1994; 5:118–123.
    1. Karmaus W, Botezan C. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Community Health. 2002;56:209–217.
    1. Strachan DP. Hay Fever, hygiene, and household size. BMJ. 1989;299:1259–1260.
    1. Schaffer SJ, Szilagyi PG. Immunization status and birth order. Arch Pediatr Adolesc Med. 1995;149:792–797.
    1. Li J, Taylor B. Factors affecting uptake of measles, mumps, and rubella immunization. BMJ. 1993;307:168–171.
    1. Ponsonby AL, Couper D, Dwyer T, Baird J. Characteristics of infants receiving prompt first diphtheria-tetanus-pertussis immunization in an infant cohort. Aust N Z J Public Health. 1997;21:489–494.
    1. Bobo JK, Gale JL, Thapa PB, Wassilak SG. Risk factors for delayed immunization in a random sample of 1163 children from Oregon and Washington. Pediatrics. 1993;91:308–314.
    1. Wiecha JM, Gann P. Does maternal prenatal care use predict infant immunization delay? Fam Med. 1994;26:172–178.
    1. Brenner RA, Simons-Morton BG, Bhaskar B, Das A, Clemens JD. Prevalence and predictors of immunization among inner-city infants: a birth cohort study. Pediatrics. 2001;108:661–670.
    1. Kemp T, Pearce N, Fitzharris P, et al. Is infant immunization a risk factor for childhood asthma or allergy? Epidemiology. 1997;8:678–680.
    1. Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax. 1998;53:927–932.
    1. Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet. 1999;353:1485–1488.
    1. Odent MR, Culpin EE, Kimmel T. Pertussis vaccination and asthma: is there a link? JAMA. 1994;272:592–593.
    1. Anderson HR, Poloniecki JD, Strachan DP, Beasley R, Bjorksten B, Asher MI. Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood. Am J Public Health. 2001;91:1126–1129.
    1. Kuehni CE, Brooke AM, Davis A, Silverman M. Vaccinations as risk factors for wheezing disorders. Lancet. 2001;358:1186.
    1. Hurwitz EL, Morgenstern H. Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States. J Manipulative Physiol Ther. 2000;23:81–90.
    1. Wickens K, Crane J, Kemp T, et al. A case-control study of risk factors for asthma in New Zealand children. Aust N Z J Public Health. 2001;25:44–49.
    1. Mullooly JP, Pearson J, Drew L, et al. Wheezing lower respiratory disease and vaccination of full-term infants. Pharmacoepidemiol Drug Saf. 2002;11:21–30.
    1. Henderson J, North K, Griffiths M, Harvey I, Golding J. Pertussis vaccination and wheezing illnesses in young children: prospective cohort study. The Longitudinal Study of Pregnancy and Childhood Team. BMJ. 1999;318:1173–1176.
    1. Nilsson L, Kjellman NI, Storsaeter J, Gustafsson L, Olin P. Lack of association between pertussis vaccination and symptoms of asthma and allergy. JAMA. 1996;275:760.
    1. Nilsson L, Kjellman NI, Bjorksten B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med. 1998;152:734–738.
    1. Jefferson T. Real or perceived adverse effects of vaccines and the media—a tale of our times. J Epidemiol Community Health. 2000;54:402–403.
    1. McKeever TM, Lewis SA, Smith C, et al. Siblings, multiple births, and the incidence of allergic disease: a birth cohort study using the West Midlands general practice research database. Thorax. 2001;56:758–762.
    1. McKeever TM, Lewis SA, Smith C, et al. Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database. J Allergy Clin Immunol. 2002;109:43–50.
    1. McKeever TM, Lewis SA, Smith C, Hubbard R. Mode of delivery and risk of developing allergic disease. J Allergy Clin Immunol. 2002;109:800–802.
    1. International Classification of Diseases, 8th Revision. Geneva, Switzerland: World Health Organization; 1965.

Source: PubMed

Sponsors et collaborateurs

Les conditions médicales

Interventions en matière de drogue

3
S'abonner