SARS-CoV-2 (COVID-19) by the numbers

Yinon M Bar-On, Avi Flamholz, Rob Phillips, Ron Milo, Yinon M Bar-On, Avi Flamholz, Rob Phillips, Ron Milo

Abstract

The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the peer-reviewed literature) about the SARS-CoV-2 virus that is responsible for the pandemic. The discussion is framed around two broad themes: i) the biology of the virus itself; ii) the characteristics of the infection of a single human host.

Keywords: SARS-CoV-2; coronavirus; epidemiology; global health; human; infectious disease; microbiology; quantitative biology; virology.

Conflict of interest statement

YB, AF, RP, RM No competing interests declared

© 2020, Bar-On et al.

Figures

Figure 1.. SARS-CoV-2 (COVID-19) by the numbers.
Figure 1.. SARS-CoV-2 (COVID-19) by the numbers.
Graphic showing what we know about the basic properties of the SARS-CoV-2 virus, such as its size and genome, and about how it interacts with the body. These topics are discussed further in the text, which also includes sources for all the values listed. This article will be updated as new data become available, and the latest version is available at: bit.ly/2WOeN64. A larger version of this figure (which was created with Biorender) is available as Supplementary file 1.

References

    1. Cavanagh D. Coronavirus IBV: further evidence that the surface projections are associated with two glycopolypeptides. Journal of General Virology. 1983;64 (Pt 8:1787–1791. doi: 10.1099/0022-1317-64-8-1787.
    1. CDC How COVID-19 spreads. [April 21, 2020];2020
    1. Chin AWH, Chu JTS, Perera MRA, Hui KPY, Yen H-L, Chan MCW, Peiris M, Poon LLM. Stability of SARS-CoV-2 in different environmental conditions. The Lancet Microbe. 2020;1:e10. doi: 10.1016/S2666-5247(20)30003-3.
    1. Couch RB, Cate TR, Douglas RG, Gerone PJ, Knight V. Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission. Bacteriological Reviews. 1966;30:517–529. doi: 10.1128/MMBR.30.3.517-529.1966.
    1. Crapo RO, Morris AH, Clayton PD, Nixon CR. Lung volumes in healthy nonsmoking adults. Bulletin Europeen De Physiopathologie Respiratoire. 1982;18:419–425.
    1. Davies NG, Klepac P, Liu Y, Prem K. Age-dependent effects in the transmission and control of COVID-19 epidemics. medRxiv. 2020 doi: 10.1101/2020.03.24.20043018.
    1. ECDC Download today's data on the geographic distribution of COVID-19 cases worldwide. [April 21, 2020];2020
    1. Escors D, Camafeita E, Ortego J, Laude H, Enjuanes L. Organization of two transmissible gastroenteritis coronavirus membrane protein topologies within the virion and core. Journal of Virology. 2001;75:12228–12240. doi: 10.1128/JVI.75.24.12228-12240.2001.
    1. Fehrenbach H, Schmiedl A, Wahlers T, Hirt SW, Brasch F, Riemann D, Richter J. Morphometric characterisation of the fine structure of human type II pneumocytes. The Anatomical Record. 1995;243:49–62. doi: 10.1002/ar.1092430107.
    1. Ferguson NM, Laydon D, Nedjati-Gilani G, Imai N, Ainslie K, Baguelin M, Bhatia S, Boonyasiri A, Cucunubá Z, Cuomo-Dannenburg G, Dighe A, Dorigatti I, Fu H, Gaythorpe K, Green W, Hamlet A, Hinsley W, Okell LC, van Elsland S, Thompson H, Verity R, Volz E, Wang H, Wang Y, Walker PGT, Walters C, Winskill P, Whittaker C, Donnelly CA, Riley S, Ghani CA. Report 9: Impact of Non-Pharmaceutical Interventions (NPIs) to Reduce COVID-19 Mortality and Healthcare Demand. Imperial College; 2020.
    1. Ferretti L, Wymant C, Kendall M, Zhao L, Nurtay A, Abeler-Dörner L, Parker M, Bonsall D, Fraser C. Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing. Science. 2020;368:eabb6936. doi: 10.1126/science.abb6936.
    1. Godet M, L'Haridon R, Vautherot JF, Laude H. TGEV Corona virus ORF4 encodes a membrane protein that is incorporated into virions. Virology. 1992;188:666–675. doi: 10.1016/0042-6822(92)90521-P.
    1. Han ZY, Weng WG, Huang QY. Characterizations of particle size distribution of the droplets exhaled by sneeze. Journal of the Royal Society Interface. 2013;10:20130560. doi: 10.1098/rsif.2013.0560.
    1. Harcourt J, Tamin A, Xi L, Kamili S, Kumar S, Wang L, Murray J, Queen K, Lynch B, Whitaker B. Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient. bioRxiv. 2020 doi: 10.1101/2020.03.02.972935.
    1. He X, Lau EHY, Wu P, Deng X, Wang J, Hao X, Lau YC, Wong JY, Guan Y, Tan X, Mo X, Chen Y, Liao B, Chen W, Hu F, Zhang Q, Zhong M, Wu Y, Zhao L, Zhang F, Cowling BJ, Li F, Leung GM. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nature Medicine. 2020;382:5. doi: 10.1038/s41591-020-0869-5.
    1. Hirano N, Fujiwara K, Matumoto M. Mouse hepatitis virus (MHV-2) Japanese Journal of Microbiology. 1976;20:219–225. doi: 10.1111/j.1348-0421.1976.tb00978.x.
    1. Hogue BG, Brian DA. Structural proteins of human respiratory coronavirus OC43. Virus Research. 1986;5:131–144. doi: 10.1016/0168-1702(86)90013-4.
    1. ICRP . Report on the Task Group on Reference Man. Oxford, UK: Pergamon Press; 1975.
    1. Ip DK, Lau LL, Leung NH, Fang VJ, Chan KH, Chu DK, Leung GM, Peiris JS, Uyeki TM, Cowling BJ. Viral shedding and transmission potential of asymptomatic and paucisymptomatic influenza virus infections in the community. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2017;64:736–742. doi: 10.1093/cid/ciw841.
    1. Jefferson T, Del Mar C, Dooley L, Ferroni E, Al-Ansary LA, Bawazeer GA, van Driel ML, Foxlee R, Rivetti A. Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review. BMJ. 2009;339:b3675. doi: 10.1136/bmj.b3675.
    1. Kim JY, Ko JH, Kim Y, Kim YJ, Kim JM, Chung YS, Kim HM, Han MG, Kim SY, Chin BS. Viral load kinetics of SARS-CoV-2 infection in first two patients in Korea. Journal of Korean Medical Science. 2020;35:e86. doi: 10.3346/jkms.2020.35.e86.
    1. Koyama T, Platt D, Parida L. Variant analysis of COVID-19 genomes. Bulletin of the World Health Organization. 2020 doi: 10.2471/BLT.20.253591.
    1. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020;579:5. doi: 10.1038/s41586-020-2180-5.
    1. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, Azman AS, Reich NG, Lessler J. The incubation period of coronavirus disease 2019 (COVID-19) From publicly reported confirmed cases: estimation and application. Annals of Internal Medicine. 2020:504. doi: 10.7326/M20-0504.
    1. Leung NHL, Chu DKW, Shiu EYC, Chan K-H, McDevitt JJ, Hau BJP, Yen H-L, Li Y, Ip DKM, Peiris JSM, Seto W-H, Leung GM, Milton DK, Cowling BJ. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nature Medicine. 2020;21:16836. doi: 10.21203/-16836/v1.
    1. Li R, Pei S, Chen B, Song Y, Zhang T, Yang W, Shaman J. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2) Science. 2020a;368:489–493. doi: 10.1126/science.abb3221.
    1. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. New England Journal of Medicine. 2020b;382:1199–1207. doi: 10.1056/NEJMoa2001316.
    1. Liu DX, Inglis SC. Association of the infectious bronchitis virus 3c protein with the virion envelope. Virology. 1991;185:911–917. doi: 10.1016/0042-6822(91)90572-S.
    1. Mercer RR, Russell ML, Roggli VL, Crapo JD. Cell number and distribution in human and rat airways. American Journal of Respiratory Cell and Molecular Biology. 1994;10:613–624. doi: 10.1165/ajrcmb.10.6.8003339.
    1. Mizumoto K, Kagaya K, Chowell G. Early epidemiological assessment of the transmission potential and virulence ofcoronavirus disease 2019 (COVID-19) in Wuhan City, China, January-February, 2020. medRxiv. 2020 doi: 10.1101/2020.02.12.20022434.
    1. Moriarty LF, Plucinski MM, Marston BJ, Kurbatova EV, Knust B, Murray EL, Pesik N, Rose D, Fitter D, Kobayashi M, Toda M, Canty PT, Scheuer T, Halsey ES, Cohen NJ, Stockman L, Wadford DA, Medley AM, Green G, Regan JJ, Tardivel K, White S, Brown C, Morales C, Yen C, Wittry B, Freeland A, Naramore S, Novak RT, Daigle D, Weinberg M, Acosta A, Herzig C, Kapella BK, Jacobson KR, Lamba K, Ishizumi A, Sarisky J, Svendsen E, Blocher T, Wu C, Charles J, Wagner R, Stewart A, Mead PS, Kurylo E, Campbell S, Murray R, Weidle P, Cetron M, Friedman CR, Behravesh CB, Bjork A, Bower W, Bozio C, Braden Z, Bertulfo MC, Chatham-Stephens K, Chu V, Cooper B, Dooling K, Dubray C, Curren E, Honein MA, Ivey K, Jones J, Kadzik M, Knight N, Marlow M, McColloch A, McDonald R, Klevos A, Poser S, Rinker RA, Ritter T, Rodriguez L, Ryan M, Schneider Z, Shockey C, Shugart J, Silver M, Smith PW, Tobolowsky F, Treffiletti A, Wallace M, Yoder J, Barry P, Berumen R, Bregman B, Campos K, Chai S, Glenn-Finer R, Guevara H, Hacker J, Hsieh K, Morris MK, Murphy R, Myers JF, Padilla T, Pan C-Y, Readhead A, Saguar E, Salas M, Snyder RE, Vugia D, Watt J, Wong C, Acosta M, Davis S, Kapuszinsky B, Matyas B, Miller G, Ntui A, Richards J. Public health responses to COVID-19 outbreaks on cruise ships — Worldwide, February–March 2020. MMWR. Morbidity and Mortality Weekly Report. 2020;69:347–352. doi: 10.15585/mmwr.mm6912e3.
    1. Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ. A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology. 2011;174:11–22. doi: 10.1016/j.jsb.2010.11.021.
    1. Ng ML, Tan SH, See EE, Ooi EE, Ling AE. Early events of SARS coronavirus infection in vero cells. Journal of Medical Virology. 2003;71:323–331. doi: 10.1002/jmv.10499.
    1. Nishiura H, Kobayashi T, Yang Y, Hayashi K, Miyama T, Kinoshita R, Linton NM, Jung S-mok, Yuan B, Suzuki A, Akhmetzhanov AR. The rate of underascertainment of novel coronavirus (2019-nCoV) Infection: estimation using Japanese passengers data on evacuation flights. Journal of Clinical Medicine. 2020;9:419. doi: 10.3390/jcm9020419.
    1. Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV. Mild and moderate asthma is associated with airway goblet cell Hyperplasia and abnormalities in mucin gene expression. American Journal of Respiratory and Critical Care Medicine. 2001;163:517–523. doi: 10.1164/ajrccm.163.2.2004039.
    1. Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples. The Lancet Infectious Diseases. 2020;20:411–412. doi: 10.1016/S1473-3099(20)30113-4.
    1. Park SW, Bolker BM, Champredon D, Earn JDD, Li M, Weitz JM. Reconciling early-outbreak estimates of the basic reproductive number and its uncertainty: framework and applications to the novel coronavirus (SARS-CoV-2) outbreak. medRxiv. 2020a doi: 10.1101/2020.01.30.20019877.
    1. Park WB, Kwon NJ, Choi SJ, Kang CK, Choe PG, Kim JY, Yun J, Lee GW, Seong MW, Kim NJ, Seo JS, Oh MD. Virus isolation from the first patient with SARS-CoV-2 in Korea. Journal of Korean Medical Science. 2020b;35:e84. doi: 10.3346/jkms.2020.35.e84.
    1. Pastorino B, Touret F, Gilles M, Lamballerie X, Charrel RN. Prolonged viability of SARS-CoV-2 in fomites. OSF Preprints. 2020 doi: 10.31219/.
    1. Rengasamy S, Shaffer R, Williams B, Smit S. A comparison of facemask and respirator filtration test methods. Journal of Occupational and Environmental Hygiene. 2017;14:92–103. doi: 10.1080/15459624.2016.1225157.
    1. Rockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, de Meulder M, van Amerongen G, van den Brand J, Okba NMA, Schipper D. Comparative pathogenesis of COVID-19, MERS and SARS in a non-human primate model. bioRxiv. 2020 doi: 10.1101/2020.03.17.995639.
    1. Russell TW, Hellewell J, Jarvis CI, van Zandvoort K, Abbott S, Ratnayake R, Flasche S, Eggo RM, Edmunds WJ, Kucharski AJ. Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020. Eurosurveillance. 2020;25:2000256. doi: 10.2807/1560-7917.ES.2020.25.12.2000256.
    1. Sanjuán R, Nebot MR, Chirico N, Mansky LM, Belshaw R. Viral mutation rates. Journal of Virology. 2010;84:9733–9748. doi: 10.1128/JVI.00694-10.
    1. Schneider M, Ackermann K, Stuart M, Wex C, Protzer U, Schätzl HM, Gilch S. Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. Journal of Virology. 2012;86:10112–10122. doi: 10.1128/JVI.01001-12.
    1. Shang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020;382 doi: 10.1038/s41586-020-2179-y.
    1. Shieh WJ, Hsiao CH, Paddock CD, Guarner J, Goldsmith CS, Tatti K, Packard M, Mueller L, Wu MZ, Rollin P, Su IJ, Zaki SR. Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan. Human Pathology. 2005;36:303–309. doi: 10.1016/j.humpath.2004.11.006.
    1. Smith EC, Denison MR. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Current Opinion in Virology. 2012;2:519–524. doi: 10.1016/j.coviro.2012.07.005.
    1. Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. Allometric relationships of cell numbers and size in the mammalian lung. American Journal of Respiratory Cell and Molecular Biology. 1992;6:235–243. doi: 10.1165/ajrcmb/6.2.235.
    1. Tellier R, Li Y, Cowling BJ, Tang JW. Recognition of aerosol transmission of infectious agents: a commentary. BMC Infectious Diseases. 2019;19:101. doi: 10.1186/s12879-019-3707-y.
    1. The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team The epidemiologicalcharacteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) China CDC Weekly. 2020;2:113–122.
    1. To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, Yip CC, Cai JP, Chan JM, Chik TS, Lau DP, Choi CY, Chen LL, Chan WM, Chan KH, Ip JD, Ng AC, Poon RW, Luo CT, Cheng VC, Chan JF, Hung IF, Chen Z, Chen H, Yuen KY. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. The Lancet. Infectious Diseases. 2020:S1473-3099(20)30196-1. doi: 10.1016/S1473-3099(20)30196-1.
    1. Tos M, Mogensen C. Density of mucous glands in the normal adult nasal septum. Archives of Oto-Rhino-Laryngology. 1976;214:125–133. doi: 10.1007/BF00453608.
    1. Tos M, Morgensen C. Density of mucous glands in the normal adult nasal turbinates. Archives of Oto-Rhino-Laryngology. 1977;215:101–111. doi: 10.1007/BF00455856.
    1. van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO, de Wit E, Munster VJ. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. New England Journal of Medicine. 2020;382:1564–1567. doi: 10.1056/NEJMc2004973.
    1. Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, Cuomo-Dannenburg G, Thompson H, Walker PGT, Fu H, Dighe A, Griffin JT, Baguelin M, Bhatia S, Boonyasiri A, Cori A, Cucunubá Z, FitzJohn R, Gaythorpe K, Green W, Hamlet A, Hinsley W, Laydon D, Nedjati-Gilani G, Riley S, van Elsland S, Volz E, Wang H, Wang Y, Xi X, Donnelly CA, Ghani AC, Ferguson NM. Estimates of the severity of coronavirus disease 2019: a model-based analysis. The Lancet Infectious Diseases. 2020;30:S1473-3099(20)30243-7. doi: 10.1016/S1473-3099(20)30243-7.
    1. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181:281–292. doi: 10.1016/j.cell.2020.02.058.
    1. WHO . Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-2019) WHO; 2020.
    1. Widdicombe JH. Early studies of airway submucosal glands. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2019;316:L990–L998. doi: 10.1152/ajplung.00068.2019.
    1. Woelfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Mueller MA, Niemeyer D, Vollmar P, Rothe C, Hoelscher M, Bleicker T, Bruenink S, Schneider J, Ehmann R, Zwirglmaier K, Drosten C, Wendtner C. Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster. medRxiv. 2020 doi: 10.1101/2020.03.05.20030502.
    1. Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, Niemeyer D, Jones TC, Vollmar P, Rothe C, Hoelscher M, Bleicker T, Brünink S, Schneider J, Ehmann R, Zwirglmaier K, Drosten C, Wendtner C. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 doi: 10.1038/s41586-020-2196-x.
    1. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260–1263. doi: 10.1126/science.abb2507.
    1. Wu LP, Wang NC, Chang YH, Tian XY, Na DY, Zhang LY, Zheng L, Lan T, Wang LF, Liang GD. Duration of antibody responses after severe acute respiratory syndrome. Emerging Infectious Diseases. 2007;13:1562–1564. doi: 10.3201/eid1310.070576.
    1. Wu Y, Guo C, Tang L, Hong Z, Zhou J, Dong X, Yin H, Xiao Q, Tang Y, Qu X, Kuang L, Fang X, Mishra N, Lu J, Shan H, Jiang G, Huang X. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The Lancet Gastroenterology & Hepatology. 2020a;5:434–435. doi: 10.1016/S2468-1253(20)30083-2.
    1. Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X, Zheng M, Chen L, Li H. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharmaceutica Sinica B. 2020b doi: 10.1016/j.apsb.2020.02.008. In press.
    1. Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, Meng J, Zhu Z, Zhang Z, Wang J, Sheng J, Quan L, Xia Z, Tan W, Cheng G, Jiang T. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host & Microbe. 2020c;27:325–328. doi: 10.1016/j.chom.2020.02.001.
    1. Xu B, Gutierrez B, Mekaru S, Sewalk K, Goodwin L, Loskill A, Cohn EL, Hswen Y, Hill SC, Cobo MM, Zarebski AE, Li S, Wu CH, Hulland E, Morgan JD, Wang L, O'Brien K, Scarpino SV, Brownstein JS, Pybus OG, Pigott DM, Kraemer MUG. Epidemiological data from the COVID-19 outbreak, real-time case information. Scientific Data. 2020;7:106. doi: 10.1038/s41597-020-0448-0.
    1. Yang S, Lee GW, Chen CM, Wu CC, Yu KP. The size and concentration of droplets generated by coughing in human subjects. Journal of Aerosol Medicine. 2007;20:484–494. doi: 10.1089/jam.2007.0610.
    1. Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Current Biology. 2020;30:1346–1351. doi: 10.1016/j.cub.2020.03.022.
    1. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. medRxiv. 2020 doi: 10.1101/2020.03.02.20030189.
    1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W, China Novel Coronavirus Investigating and Research Team A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine. 2020;382:727–733. doi: 10.1056/NEJMoa2001017.

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