Postponing surgery to optimise patients with acute right-sided obstructing colon cancer - A pilot study
Jeske R E Boeding, Iris E Cuperus, Arjen M Rijken, Rogier M P H Crolla, Cornelis Verhoef, Paul D Gobardhan, Jennifer M J Schreinemakers, Jeske R E Boeding, Iris E Cuperus, Arjen M Rijken, Rogier M P H Crolla, Cornelis Verhoef, Paul D Gobardhan, Jennifer M J Schreinemakers
Abstract
Background: Right-sided obstructing colon cancer is most often treated with acute resection. Recent studies on right-sided obstructing colon cancer report higher mortality and morbidity rates than those in patients without obstruction. The aim of this study is to retrospectively analyse whether it is possible to optimise the health condition of patients with acute right-sided obstructing colon cancer, prior to surgery, and whether this improves postoperative outcomes.
Method: All consecutive patients with high suspicion of, or histologically proven, right-sided obstructing colon cancer, treated with curative intent between March 2013 and December 2019, were analysed retrospectively. Patients were divided into two groups: optimised group and non-optimised group. Pre-operative optimisation included additional nutrition, physiotherapy, and, if needed, bowel decompression.
Results: In total, 54 patients were analysed in this study. Twenty-four patients received optimisation before elective surgery, and thirty patients received emergency surgery, without optimisation. Scheduled surgery was performed after a median of eight days (IQR 7-12). Postoperative complications were found in twelve (50%) patients in the optimised group, compared to twenty-three (77%) patients in the non-optimised group (p = 0.051). Major complications were diagnosed in three (13%) patients with optimisation, compared to ten (33%) patients without optimisation (p = 0.111). Postoperative in-hospital stay, 30-day mortality, as well as primary anastomosis were comparable in both groups.
Conclusion: This pilot study suggests that pre-operative optimisation of patients with obstructing right sided colonic cancer may be feasible and safe but is associated with longer in-patient stay.
Keywords: Colon cancer; Emergency resection; Morbidity; Mortality; Obstruction; Optimisation.
Conflict of interest statement
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jeske R.E. Boeding reports financial support was provided by Wetenschapsfonds Amphia.
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Source: PubMed