A Nutraceutical Formula Is Effective in Raising the Circulating Vitamin and Mineral Levels in Healthy Subjects: A Randomized Trial

Hatice Zeynep Nenseth, Aparna Sahu, Fahri Saatcioglu, Steven Osguthorpe, Hatice Zeynep Nenseth, Aparna Sahu, Fahri Saatcioglu, Steven Osguthorpe

Abstract

Low levels of nutrient intake are common in industrialized countries. This has negative implications on health and is associated with chronic diseases. Supplementation of vitamins, minerals, and key nutrients to optimal levels may, therefore, be beneficial for individual health and for the health economy. Although the use of supplements has become very common, due to a lack of monitoring, there is very limited data on the efficacy of supplementation with different formulas. In this study, we present the results of a randomized controlled study on the efficacy of a novel formulated nutraceutical, N247, in 250 healthy volunteers aged 26-75 years and a placebo control group (n = 35). The broad-spectrum formulation of N247 includes essential vitamins, minerals, and trace elements that are adequately balanced in regard to synergies and related metabolic functions. Moreover, tolerance, safety, and nutrient availability is an important aspect of daily, long-term use of N247. After 3 months of regular N247 use, levels of vitamins and minerals in serum were significantly increased in the N247 group compared with the control group and a placebo group, with excellent compliance rates. Coupled with additional natural ingredients that aim to increase the potency of the nutrients, N247 may represent a novel and beneficial supplement for individuals with nutritional deficiencies. Clinical Trial Registration:https://ichgcp.net/clinical-trials-registry/NCT04054505" title="See in ClinicalTrials.gov">NCT04054505.

Keywords: clinical trial; minerals; nutraceuticals; supplementation; vitamins.

Conflict of interest statement

SO is employed by the company Optimal Health Research. SO is married to Dianne Osguthorpe, the owner of ReaLifeResources, Inc, which is the owner of N247, the subject matter of this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Nenseth, Sahu, Saatcioglu and Osguthorpe.

Figures

Figure 1
Figure 1
Consort diagram.
Figure 2
Figure 2
Graphical representation of N247 effects on serum vitamin A, C, D, and E levels. Serum concentrations of vitamin A (A), vitamin C (B), vitamin D (C), and vitamin E (D) in control and N247 receiving group of women and men subjects during the study. Values are mean ± SEM.
Figure 3
Figure 3
Serum concentrations of vitamin A, C, D, and E. Values are mean ± SD. % values are given in parentheses.
Figure 4
Figure 4
Graphical representation of N247 effects on serum vitamin B1, B2, B6, and B12 levels. Serum concentrations of vitamin B1 (A), vitamin B2 (B), vitamin B6 (C), and vitamin B12 (D) in control and N247 receiving group of women and men subjects during the study. Values are mean ± SEM.
Figure 5
Figure 5
Serum concentrations of vitamin B1, B2, B6, and B12. Values are mean ± SD% values are given in parentheses.
Figure 6
Figure 6
Graphical representation of N247 effects on serum calcium, iron, IGF-1, and FT-3 levels. Serum concentrations of calcium (A), iron (B), IGF-1 (C), and FT-3 (D) in control and N247 receiving group of women and men subjects during the study of 3 months. Values are mean ± SEM.
Figure 7
Figure 7
Serum concentrations of calcium, iron, IGF-1, and FT-3. Values are mean ± SD% values are given in parentheses.

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