Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study

Liwen Chen, Chaohua Deng, Xuhui Chen, Xian Zhang, Bo Chen, Huimin Yu, Yuanjun Qin, Ke Xiao, Hong Zhang, Xufang Sun, Liwen Chen, Chaohua Deng, Xuhui Chen, Xian Zhang, Bo Chen, Huimin Yu, Yuanjun Qin, Ke Xiao, Hong Zhang, Xufang Sun

Abstract

Purpose: To investigate the ocular manifestations and clinical characteristics of COVID-19 patients caused by SARS-CoV-2 in Wuhan, China.

Methods: A total of 535 COVID-19 patients were recruited at Mobile Cabin Hospital and Tongji Hospital. Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records.

Results: Of 535 patients, 27 patients (5.0%) presented with conjunctival congestion and 4 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 5.9 ± 4.5 days (mean [SD]). The other ocular symptoms, including increased conjunctival secretion, ocular pain, photophobia, dry eye and tearing, were also found in patients with conjunctival congestion. Notably, hand-eye contact was independently correlated with conjunctival congestion in COVID-19 patients. We also found that some COVID-19 patients had chronic eye diseases, including conjunctivitis (33, 6.2%), xerophthalmia (24, 4.5%) and keratitis (14, 2.6%). Similar to the published studies, the most common clinical symptoms were fever, cough and fatigue. A total of 343 patients (64.1%) had positive SARS-CoV-2 detection in nasopharyngeal swabs.

Conclusions: Conjunctival congestion is one of the COVID-19-related ocular symptoms, which could occur as the initial symptoms. Frequent hand-eye contact may be the risk factor for conjunctival congestion in COVID-19 patients. Screening of patients with conjunctival congestion by ophthalmologists is advocated during the outbreak of COVID-19. It is essential to provide eye-care equipment and strengthen education on eye protection.

Keywords: COVID-19; SARS-CoV-2; conjunctival congestion; hand-eye contact; ocular manifestations.

© 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Figures

Fig. 1
Fig. 1
Flow chart for the study profile. A total of 535 patients were finally valid for the study.
Fig. 2
Fig. 2
Detailed information about the duration of conjunctival congestion, the onset date of clinical symptoms in 27 patients with conjunctival congestion. (A) The numbers in boxes are calendar dates from 20 January 2019 to 7 March 2020. Dark grey box – onset date of the first clinical symptoms; light grey box – conjunctival congestion. (B) Days after clinical symptoms occurring conjunctival congestion. Four (14.8%) patients had conjunctival congestion as an initial symptom.

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