Abnormalities of regional brain function in Parkinson's disease: a meta-analysis of resting state functional magnetic resonance imaging studies

PingLei Pan, Yang Zhang, Yi Liu, He Zhang, DeNing Guan, Yun Xu, PingLei Pan, Yang Zhang, Yi Liu, He Zhang, DeNing Guan, Yun Xu

Abstract

There is convincing evidence that abnormalities of regional brain function exist in Parkinson's disease (PD). However, many resting-state functional magnetic resonance imaging (rs-fMRI) studies using amplitude of low-frequency fluctuations (ALFF) have reported inconsistent results about regional spontaneous neuronal activity in PD. Therefore, we conducted a comprehensive meta-analysis using the Seed-based d Mapping and several complementary analyses. We searched PubMed, Embase, and Web of Science databases for eligible whole-brain rs-fMRI studies that measured ALFF differences between patients with PD and healthy controls published from January 1st, 2000 until June 24, 2016. Eleven studies reporting 14 comparisons, comparing 421 patients and 381 healthy controls, were included. The most consistent and replicable findings in patients with PD compared with healthy controls were identified, including the decreased ALFFs in the bilateral supplementary motor areas, left putamen, left premotor cortex, and left inferior parietal gyrus, and increased ALFFs in the right inferior parietal gyrus. The altered ALFFs in these brain regions are related to motor deficits and compensation in PD, which contribute to understanding its neurobiological underpinnings and could serve as specific regions of interest for further studies.

Figures

Figure 1. Flow diagram for inclusion/exclusion of…
Figure 1. Flow diagram for inclusion/exclusion of studies.
Key: PD, Parkinson’s disease; ALFF, amplitude of low-frequency fluctuations.
Figure 2. ALFF differences in patients with…
Figure 2. ALFF differences in patients with PD compared to healthy controls.
Key: Red and green colors indicate increased and decreased ALFFs in patients with PD compared to healthy controls, respectively. ALFF, amplitude of low-frequency fluctuations; (A), Right inferior temporal/middle temporal/fusiform/parahippocampal gyri; (B), Right inferior parietal gyrus; (C), Brainstem (pons and midbrain); (D), Right orbitofrontal cortex; (E), Left/Right cuneus cortices; (F), Left/Right supplementary motor areas; (G), Left putamen; (H), Left cuneus cortex; (I), Left inferior parietal gyrus; (J), Left lateral premotor cortex.

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