A comparison of cognitive bias modification for interpretation and computerized cognitive behavior therapy: effects on anxiety, depression, attentional control, and interpretive bias

Jennifer O Bowler, Bundy Mackintosh, Barnaby D Dunn, Andrew Mathews, Tim Dalgleish, Laura Hoppitt, Jennifer O Bowler, Bundy Mackintosh, Barnaby D Dunn, Andrew Mathews, Tim Dalgleish, Laura Hoppitt

Abstract

Objective: Computerized cognitive behavioral therapy (cCBT) and cognitive bias modification for interpretation (CBM-I) both have demonstrated efficacy in alleviating social anxiety, but how they compare with each other has not been investigated. The present study tested the prediction that both interventions would reduce anxiety relative to a no-intervention comparison condition, but CBM-I would be particularly effective at modifying threat-related cognitive bias under high mental load.

Method: Sixty-three primarily Caucasian adults (mean age = 22.7, SD = 5.87; 68.3% female) with high social anxiety, randomly allocated to 3 groups: CBM-I (n = 21), cCBT (n = 21), and a no-intervention control group (n = 21) provided complete data for analysis. Pre- and postintervention (4 sessions lasting 2 weeks, control participants only attended the pre-post sessions) self-report measures of anxiety, depression, attentional control, and threat-related interpretive bias were completed. In addition, interpretive bias under high versus low cognitive load was measured using the Scrambled Sentences Test.

Results: Both CBM-I and cCBT groups reported significantly reduced levels of social anxiety, trait anxiety, and depression and improved attentional control, relative to the control group, with no clear superiority of either active intervention. Although both active conditions reduced negative bias on the Scrambled Sentences Test completed under mental load, CBM-I was significantly more effective at doing so.

Conclusions: The results suggest that although not differing in therapeutic efficacy, CBM-I and cCBT might differ in the resilience of their effects when under mental load.

Figures

Figure 1. Consolidated Standards of Reporting Trials…
Figure 1. Consolidated Standards of Reporting Trials (CONSORT) diagram illustrating flow of participants through the study. CBM-I = cognitive bias modification for interpretation; cCBT = computer-aided version of cognitive behavioral therapy.
Figure 2. Mean difference scores (pre- minus…
Figure 2. Mean difference scores (pre- minus postintervention) for the Fear of Negative Evaluation Scale (FNE), Social Phobia Inventory (SPIN), Trait scale of the Spielberger State–Trait Anxiety Inventory (STAI), Beck Depression Inventory–II (BDI-II), and Attentional Control Scale (ACS; post- minus preintervention) by group (a higher score indicates greater improvement in anxiety, depression, and attentional control). Error bars represent ± 1 standard error. CBM-I = cognitive bias modification for interpretation; cCBT = computer-aided version of cognitive behavioral therapy.
Figure 3. Mean difference scores (pre- minus…
Figure 3. Mean difference scores (pre- minus postintervention) for the Scrambled Sentences Test (SST) by group (a more positive score indicates a greater reduction in the proportion of negative resolutions generated). Error bars represent ± 1 standard error. CBM-I = cognitive bias modification for interpretation; cCBT = computer-aided version of cognitive behavioral therapy.

References

    1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
    1. Amir N., Beard C., Taylor L. T., Klumpp H., Elias J., Burns M., & Chen X. (2009). Attention training in individuals with generalized social phobia: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 77, 961–973. doi:10.1037/a0016685
    1. Amir N., Bomyea J., & Beard C. (2010). The effect of a single-session interpretation modification on attention bias in socially anxious individuals. Journal of Anxiety Disorders, 24, 178–182. doi:10.1016/j.janxdis.2009.10.005
    1. Amir N., & Taylor C. T. (2012a). Combining computerized home-based treatments for generalized anxiety disorder: An attention modification program and cognitive behavioral therapy. Behavior Therapy, 43, 546–559. doi:10.1016/j.beth.2010.12.008
    1. Amir N., & Taylor C. T. (2012b). Interpretation training in individuals with generalized social anxiety disorder: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 80, 497–511. doi:10.1037/a0026928
    1. Andersson G., Carlbring P., Berger T., Almlov J., & Cuijpers P. (2009). What makes internet therapy work? Cognitive Behaviour Therapy, 38, 55–60. doi:10.1080/16506070902916400
    1. Baert S., De Raedt R., & Koster E. H. W. (2011). Modification of information processing biases in emotional disorders: Clinically relevant developments in experimental psychopathology. International Journal of Cognitive Therapy, 4, 205–219. doi:10.1521/ijct.2011.4.2.208
    1. Bar-Haim Y. (2010). Research review: Attention bias modification (ABM): A novel treatment for anxiety disorders. The Journal of Child Psychology and Psychiatry, 51, 859–870. doi:10.1111/j.1469-7610.2010.02251.x
    1. Bar-Haim Y., Lamy D., Pergamin L., Bakermans-Kranenburg M. J., & van IJzendoorn M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133, 1–24. doi:10.1037/0033-2909.133.1.1
    1. Beard C., & Amir N. (2008). A multi-session interpretation modification program: Changes in interpretation and social anxiety symptoms. Behaviour Research and Therapy, 46, 1135–1141. doi:10.1016/j.brat.2008.05.012
    1. Beard C., Weisberg R. B., & Amir N. (2011). Combined cognitive bias modification treatment for social anxiety disorder: A pilot trial. Depression and Anxiety, 28, 981–988. doi:10.1002/da.20873
    1. Beck A. T., & Clark D. A. (1997). An information processing model of anxiety: Automatic and strategic processes. Behaviour Research and Therapy, 35, 49–59.
    1. Beck A. T., Steer R. A., & Brown G. K. (1996). Beck Depression Inventory–II (BDI-II). Manual for the Beck Depression Inventory–II. San Antonio, TX: Psychological Corporation.
    1. Berger T., Caspar F., Richardson R., Kneubühler B., Sutter D., & Andersson G. (2011). Internet-based treatment of social phobia: A randomized controlled trial comparing unguided with two types of guided self-help. Behaviour Research and Therapy, 49, 158–169. doi:10.1016/j.brat.2010.12.007
    1. Bishop S., Duncan J., Brett M., & Lawrence A. D. (2004). Prefrontal cortical function and anxiety: Controlling attention to threat-related stimuli. Nature Neuroscience, 7, 184–188. doi:10.1038/nn1173
    1. Blackwell S. E., & Holmes E. A. (2010). Modifying interpretation and imagination in clinical depression: A single case series using cognitive bias modification. Applied Cognitive Psychology, 24, 338–350. doi:10.1002/acp.1680
    1. Brosan L., Hoppitt L., Shelfer L., Sillence A., & Mackintosh B. (2011). Cognitive bias modification for attention and interpretation reduces trait and state anxiety in anxious patients referred to an out-patient service: Results from a pilot study. Journal of Behavior Therapy and Experimental Psychiatry, 42, 258–264. doi:10.1016/j.jbtep.2010.12.006
    1. Browning M., Holmes E. A., Murphy S. E., Goodwin G. M., & Harmer C. (2010). Lateral prefrontal cortex mediates the cognitive modification of attentional bias. Biological Psychiatry, 67, 919–925. doi:10.1016/j.biopsych.2009.10.031
    1. Calear A. L., Christensen H., Mackinnon A., Griffiths K. M., & O'Kearney R. (2009). The YouthMood Project: A cluster randomized controlled trial of an online cognitive behavioral program with adolescents. Journal of Consulting and Clinical Psychology, 77, 1021–1032. doi:10.1037/a0017391
    1. Carlbring P., Nordgren L. B., Furmack T., & Andersson G. (2009). Long-term outcome of Internet-delivered cognitive–behavioural therapy for social phobia: A 30-month follow-up. Behaviour Research and Therapy, 47, 848–850. doi:10.1016/j.brat.2009.06.012
    1. Christensen H., Guastella A. J., Mackinnon A. J., Griffiths K. M., Eagleson C., Batterham P. J., & Hickie I. B. (2010). Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder. Trials, 11(48), 1–8.
    1. Clark D. M., & McManus F. (2002). Information processing in social phobia. Biological Psychiatry, 51, 92–100. doi:10.1016/S0006-3223(01)01296-3
    1. Connor K. M., Davidson J. R. T., Churchill L. E., Sherwood A., Foa E., & Weisler R. H. (2000). Psychometric properties of the Social Phobia Inventory (SPIN): New self-rating scale. British Journal of Psychiatry, 176, 379–386. doi:10.1192/bjp.176.4.379
    1. Department of Health/Improving Access to Psychological Therapies. (2011). The IAPT data handbook: Guidance on recording and monitoring outcomes to support local evidence-based practice, Version 2.0.1. Retrieved from
    1. Derryberry D., & Reed M. A. (2002). Anxiety-related attentional biases and their regulation by attentional control. Journal of Abnormal Psychology, 111, 225–236. doi:10.1037/0021-843X.111.2.225
    1. DeRubeis R. J., Siegle G. R., & Hollon S. D. (2008). Cognitive therapy versus medication for depression: Treatment outcomes and neural mechanisms. Nature Reviews Neuroscience, 9, 788–796. doi:10.1038/nrn2345
    1. Eldar S., & Bar-Haim Y. (2010). Neural plasticity in response to attention training in anxiety. Psychological Medicine, 40, 667–677. doi:10.1017/S0033291709990766
    1. Fehm L., Pelissolo A., Furmark T., & Hans-Ulrich W. (2005). Size and burden of social phobia in Europe. European Neuropsychopharmacology, 15, 453–462. doi:10.1016/j.euroneuro.2005.04.002
    1. Hertel P. T., & Mathews A. (2011). Cognitive bias modification: Past perspectives, current findings, and future applications. Perspectives on Psychological Science, 6, 521–536. doi:10.1177/1745691611421205
    1. Hofmann S. G., & Smits J. A. J. (2008). Cognitive-behavioral therapy for adult anxiety disorders: A meta-analysis of randomized placebo-controlled trials. Journal of Clinical Psychiatry, 69, 621–632.
    1. Holmes E. A., Mathews A., Dalgleish, & Mackintosh B. (2006). Positive interpretation training: Effects of mental imagery versus verbal training on positive mood. Behavior Therapy, 37, 237–247. doi:10.1016/j.beth.2006.02.002
    1. Hoppitt L., Mathews A., Yiend J., & Mackintosh B. (2010). Cognitive bias modification: The critical role of active training in modifying emotional responses. Behavior Therapy, 41, 73–81. doi:10.1016/j.beth.2009.01.002
    1. Jacobson N. S., & Truax P. (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59, 12–19. doi:10.1037/0022-006X.59.1.12
    1. Kaltenthaler E., Brazier J., De Nigris E., Tumur I., Ferriter M., Beverley C., & Sutcliffe P. (2006). Computerised cognitive behaviour therapy for depression and anxiety update: A systematic review and economic evaluation. Health Technology Assessment, 10(33).
    1. Kessler R. C., Berglund P., Demler O., Jin R., Merikangas K. R., & Walters E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM–IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593–602. doi:10.1001/archpsyc.62.6.593
    1. Krebs G., Hirsch C. R., & Mathews A. (2010). The effect of attention modification with explicit vs. minimal instructions on worry. Behaviour Research and Therapy, 48, 251–256. doi:10.1016/j.brat.2009.10.009
    1. Kuyken W., Watkins E., Holden E., White K., Taylor R. S., Byford S., & Dalgleish T. (2010). How does mindfulness-based cognitive therapy work? Behaviour Research and Therapy, 48, 1105–1112. doi:10.1016/j.brat.2010.08.003
    1. Little R. J. A., & Rubin D. B. (1987). Statistical analysis with missing data. New York, NY: Wiley.
    1. Mathews A. (2006). Towards an experimental science of CBT. Behavior Therapy, 37, 314–318. doi:10.1016/j.beth.2006.02.004
    1. Mathews A., & Mackintosh B. (1998). A cognitive model of selective processing in anxiety. Cognitive Therapy and Research, 22, 539–560. doi:10.1023/A:1018738019346
    1. Mathews A., & Mackintosh B. (2000). Induced emotional interpretation bias and anxiety. Journal of Abnormal Psychology, 109, 602–615. doi:10.1037/0021-843X.109.4.602
    1. Mathews A., Ridgeway V., Cook E., & Yiend J. (2007). Inducing a benign interpretational bias reduces trait anxiety. Journal of Behaviour Therapy and Experimental Psychiatry, 38, 225–236. doi:10.1016/j.jbtep.2006.10.011
    1. Mobini S., Reynolds S., & Mackintosh B. (2012). Clinical implications of cognitive bias modification for interpretive biases in social anxiety: An integrative literature review. Cognitive Therapy and Research. doi:10.1007/s10608-012-9445-8
    1. Murphy R., Hirsch C. R., Mathews A., Smith K., & Clark D. M. (2007). Facilitating a benign interpretation bias in a highly socially anxious population. Behaviour Research and Therapy, 45, 1517–1529. doi:10.1016/j.brat.2007.01.007
    1. Nordgreen T., Havik O. E., Öst L. G., Furmark T., Carlbring P., & Andersson G. (2012). Outcome predictors in guided and unguided self-help for social anxiety disorder. Behaviour Research and Therapy, 50, 13–21. doi:10.1016/j.brat.2011.10.009
    1. Preacher K. J., & Hayes A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40, 879–891. doi:10.3758/BRM.40.3.879
    1. Proudfoot J., Ryden C., Everitt B., Shapiro D. A., Goldberg D., Mann A., & Gray J. A. (2004). Clinical efficacy of computerised cognitive-behavioural therapy for anxiety and depression in primary care: Randomised controlled trial. The British Journal of Psychiatry, 185, 46–54. doi:10.1192/bjp.185.1.46
    1. Salemink E., van den Hout M., & Kindt M. (2009). Effects of positive interpretive bias modification in highly anxious individuals. Journal of Anxiety Disorders, 23, 676–683. doi:10.1016/j.janxdis.2009.02.006
    1. Schmidt N. B., Richey J. A., Buckner J. D., & Timpano K. R. (2009). Attention training for generalized social anxiety disorder. Journal of Abnormal Psychology, 118, 5–14. doi:10.1037/a0013643
    1. Schneider W., Eschman A., & Zuccolotto A. (2002). E-Prime user's guide. Pittsburgh, PA: Psychology Software Tools.
    1. Schulz K. F., Altman D. G., Moher D., & the CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. PLoS Med, 7(3): e1000251. doi:10.1371/journal.pmed.1000251
    1. Spielberger C. D., Gorsuch R. L., Lushene R., Vagg P. R., & Jacobs G. A. (1983). Manual for the State–Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
    1. Standage H., Ashwin C., & Fox E. (2010). Is manipulation of mood a critical component of cognitive bias modification procedures? Behaviour Research and Therapy, 48, 4–10. doi:10.1016/j.brat.2009.08.005
    1. Stopa L., & Clark D. M. (2000). Social phobia and interpretation of social events. Behaviour Research and Therapy, 38, 273–283. doi:10.1016/S0005-7967(99)00043-1
    1. Teasdale J. D., Segal Z., & Williams J. M. G. (1995). How does cognitive therapy prevent depressive relapse and why should attentional control (mindfulness) training help? Behaviour Research and Therapy, 33, 25–39. doi:10.1016/0005-7967(94)E0011–7
    1. Tobon J. I., Ouimet A. J., & Dozois D. J. A. (2011). Attentional bias in anxiety disorders following cognitive behavioral treatment. Journal of Cognitive Psychotherapy, 25, 114–129. doi:10.1891/0889-8391.25.2.114
    1. Watkins E. R., & Moulds M. (2007). Revealing negative thinking in recovered major depression: A preliminary investigation. Behaviour Research and Therapy, 45, 3069–3076.
    1. Watson D., & Friend R. (1969). Measurement of social-evaluative anxiety. Journal of Consulting and Clinical Psychology, 33, 448–457. doi:10.1037/h0027806
    1. Wenzlaff R. M. (1993). The mental control of depression: Psychological obstacles to emotional well-being. In Wegner D. M. & Pennebaker J. W. (Eds.), Handbook of mental control (pp. 239–257). Englewood Cliffs, NJ: Prentice Hall.
    1. Wenzlaff R. M., Rude S. S., Taylor C. J., Stultz C. H., & Sweatt R. A. (2001). Beneath the veil of thought suppression: Attentional bias and depression risk. Cognition & Emotion, 15, 435–452.
    1. Wiers R. W., Eberl C., Rinck M., Becker E. S., & Lindenmeyer J. (2011). Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome. Psychological Science, 22, 490–497. doi:10.1177/0956797611400615
    1. Wilson E., MacLeod C., Mathews A., & Rutherford E. M. (2006). The causal role of interpretive bias in vulnerability to anxiety. Journal of Abnormal Psychology, 115, 103–111.
    1. Wittchen H.-U., & Jacobi F. (2005). Size and burden of mental disorders in Europe—A critical review and appraisal of 27 studies. European Neuropsychopharmacology, 15, 357–376. doi:10.1016/j.euroneuro.2005.04.012

Source: PubMed

3
S'abonner