Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death

Samuel J Gentle, Benjamin Carper, Matthew M Laughon, Erik A Jensen, Austin Williams, Colm P Travers, Namasivayam Ambalavanan, Charitharth V Lal, Waldemar A Carlo, Samuel J Gentle, Benjamin Carper, Matthew M Laughon, Erik A Jensen, Austin Williams, Colm P Travers, Namasivayam Ambalavanan, Charitharth V Lal, Waldemar A Carlo

Abstract

Objective: To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants.

Methods: Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity.

Results: Among 6268 infants 36% developed BPD or died. The median duration of noninvasive respiratory support was 18 days. There was inconsistency in the association between noninvasive support and BPD or death when analyzed by instrumental variable techniques (Average Marginal Effect -0.37; 95% CI -1.23 to 0.50) and generalized propensity score matching (Average Marginal Effect 0.46; 95% CI 0.33 to 0.60).

Conclusion: Findings on the association between duration of exposure to noninvasive respiratory support and the development of BPD or death were inconclusive.

Gov id: Generic Database:NCT00063063.

Conflict of interest statement

Conflict of Interest: The authors have indicated they have no potential conflicts of interest to disclose.

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

Figures

Figure 1.
Figure 1.
A, Dose response function linking the percentage of hospital days of noninvasive support exposure and risk of death. B, Dose response function linking support exposure and risk of BPD. Confidence bounds at 0.95% level. Dose response function is the probability of a positive outcome.

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