The prognostic importance of lung function in patients admitted with heart failure
Kasper Karmark Iversen, Jesper Kjaergaard, Dilek Akkan, Lars Kober, Christian Torp-Pedersen, Christian Hassager, Jorgen Vestbo, Erik Kjoller, ECHOS Lung Function Study Group, Finn Gustafsson, Per Hildebrandt, Søren Nielsen, Dorte Raae, Lars Køber, Søren Boesgaard, Birgit Haugaard, Rune Pallesen, Lilly Knudsen, Joan Hummelshøj, Hans Rickers, Peter Torp, Jens Refsgaard, Dines Dinesen, Erik S Nielsen, Birgit Vang, Mette Toftdahl, Else Marie Dalberg, Jens Rokkedal, Nis Høst, Lia Bang, Rene Worck, Keld Neland, Mary Bülow, Anne-Lise Jørgensen, Kenneth Egstrup, Mirza Husic, Betina Nørager, Magdalene Böhme, Anni Due, Inge Faurskov, Margret Lundgaard, Erik Agner, Jørgen Kanters, Anette Lanng, Lena Hornum, Hannah Gottschalchk, Christian Torp Petersen, Ulla Jørgensen, Henrik Nielsen, Kasper Karmark Iversen, Helle Hempel, Erik Kjøller, Knud Skagen, Anni Therkelsen, Kasper Karmark Iversen, Jesper Kjaergaard, Dilek Akkan, Lars Kober, Christian Torp-Pedersen, Christian Hassager, Jorgen Vestbo, Erik Kjoller, ECHOS Lung Function Study Group, Finn Gustafsson, Per Hildebrandt, Søren Nielsen, Dorte Raae, Lars Køber, Søren Boesgaard, Birgit Haugaard, Rune Pallesen, Lilly Knudsen, Joan Hummelshøj, Hans Rickers, Peter Torp, Jens Refsgaard, Dines Dinesen, Erik S Nielsen, Birgit Vang, Mette Toftdahl, Else Marie Dalberg, Jens Rokkedal, Nis Høst, Lia Bang, Rene Worck, Keld Neland, Mary Bülow, Anne-Lise Jørgensen, Kenneth Egstrup, Mirza Husic, Betina Nørager, Magdalene Böhme, Anni Due, Inge Faurskov, Margret Lundgaard, Erik Agner, Jørgen Kanters, Anette Lanng, Lena Hornum, Hannah Gottschalchk, Christian Torp Petersen, Ulla Jørgensen, Henrik Nielsen, Kasper Karmark Iversen, Helle Hempel, Erik Kjøller, Knud Skagen, Anni Therkelsen
Abstract
Aims: The purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF).
Methods and results: This was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV(1)) was 65% of the predicted value [95% confidence interval (CI) 63-67%], mean forced vital capacity (FVC) was 71% of predicted (95% CI 69-72%), and FEV(1)/FVC was 0.72 (95% CI 0.71-0.73). FEV(1), FVC, and FEV(1)/FVC were all significant prognostic factors for all-cause mortality in univariate analyses. In a multivariate analysis, FEV(1) had independent prognostic value (hazard ratio 0.86 per 10% change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self-reported chronic obstructive pulmonary disease.
Conclusion: Pulmonary function provides significant prognostic information for all-cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.
Source: PubMed