Endocrine and metabolic link to coronavirus infection

Stefan R Bornstein, Rinkoo Dalan, David Hopkins, Geltrude Mingrone, Bernhard O Boehm, Stefan R Bornstein, Rinkoo Dalan, David Hopkins, Geltrude Mingrone, Bernhard O Boehm

Abstract

Type 2 diabetes mellitus and hypertension are the most common comorbidities in patients with coronavirus infections. Emerging evidence demonstrates an important direct metabolic and endocrine mechanistic link to the viral disease process. Clinicians need to ensure early and thorough metabolic control for all patients affected by COVID-19.

Conflict of interest statement

The authors declare no competing interests.

References

    1. Yang JK, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet. Med. 2006;23:623–628. doi: 10.1111/j.1464-5491.2006.01861.x.
    1. Kulcsar KA, Coleman CM, Beck SE, Frieman MB. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight. 2019;4:131774. doi: 10.1172/jci.insight.131774.
    1. Mehta D, et al. Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 doi: 10.1016/S0140-6736(20)30628-0.
    1. Hoffmann M, et al. SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 doi: 10.1016/j.cell.2020.02.05.
    1. Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1–7) and Mas receptor axis in inflammation and fibrosis. Br. J. Pharmacol. 2013;169:477–492. doi: 10.1111/bph.12159.
    1. Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47:193–199. doi: 10.1007/s00592-009-0109-4.
    1. Roca-Ho H, Riera M, Palau V, Pascual J, Soler MJ. Characterization of ACE and ACE2 expression within different organs of the NOD mouse. Int. J. Mol. Sci. 2017;18:E563. doi: 10.3390/ijms18030563.
    1. Jia D, Taguchi M, Otsuki M. Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats. Metabolism. 2005;54:619–627. doi: 10.1016/j.metabol.2004.12.005.
    1. Marshall AC, et al. Betamethasone exposure attenuates angiotensin-(1–7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44:25–31. doi: 10.1016/j.peptides.2013.03.018.
    1. Gupta A. Real-world clinical effectiveness and tolerability of hydroxychloroquine 400 mg in uncontrolled type 2 diabetes subjects who are not willing to initiate insulin therapy (HYQ-Real-World Study) Curr. Diabetes Rev. 2019;15:510–519. doi: 10.2174/1573399815666190425182008.

Source: PubMed

Sponsors et collaborateurs

Les conditions médicales

Interventions en matière de drogue

3
S'abonner