ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project
Kerry J Savage, Nancy Lee Harris, Julie M Vose, Fred Ullrich, Elaine S Jaffe, Joseph M Connors, Lisa Rimsza, Stefano A Pileri, Mukesh Chhanabhai, Randy D Gascoyne, James O Armitage, Dennis D Weisenburger, International Peripheral T-Cell Lymphoma Project, Kerry Savage, Joseph Connors, Randy Gascoyne, Mukesh Chhanabhai, Wyndham Wilson, Elaine Jaffe, James Armitage, Julie Vose, Dennis Weisenburger, James Anderson, Fred Ullrich, Martin Bast, Ephraim Hochberg, Nancy Harris, Alexandra Levine, Bharat Nathwani, Thomas Miller, Lisa Rimsza, Emili Montserrat, Armando Lopez-Guillermo, Elias Campo, Marta Cuadros, Javier Alvarez Ferreira, Beatriz Martinez Delgado, Harold Holte, Jan Delabie, Thomas Rüdiger, Konrad Müller-Hermelink, Peter Reimer, Patrick Adam, Martin Wilhelm, Norbert Schmitz, Christoph Nerl, Andrew Lister, Andrew Norton, Kenneth A MacLennan, Pier Luigi Zinzani, Stefano Pileri, Massimo Federico, Monica Bellei, Bertrand Coiffier, Francoise Berger, Intragumtornchai Tanin, Pongsak Wannakrairot, Wing Au, Raymond Liang, Florence Loong, Sandeep Rajan, Ivy Sng, Kensei Tobinai, Yoshihiro Matsuno, Yasuo Morishima, Shigeo Nakamura, Masao Seto, Mitsune Tanimoto, Tadashi Yoshino, Junji Suzumiya, Koichi Ohshima, Won-Seog Kim, Young-Hyeh Ko, Kerry J Savage, Nancy Lee Harris, Julie M Vose, Fred Ullrich, Elaine S Jaffe, Joseph M Connors, Lisa Rimsza, Stefano A Pileri, Mukesh Chhanabhai, Randy D Gascoyne, James O Armitage, Dennis D Weisenburger, International Peripheral T-Cell Lymphoma Project, Kerry Savage, Joseph Connors, Randy Gascoyne, Mukesh Chhanabhai, Wyndham Wilson, Elaine Jaffe, James Armitage, Julie Vose, Dennis Weisenburger, James Anderson, Fred Ullrich, Martin Bast, Ephraim Hochberg, Nancy Harris, Alexandra Levine, Bharat Nathwani, Thomas Miller, Lisa Rimsza, Emili Montserrat, Armando Lopez-Guillermo, Elias Campo, Marta Cuadros, Javier Alvarez Ferreira, Beatriz Martinez Delgado, Harold Holte, Jan Delabie, Thomas Rüdiger, Konrad Müller-Hermelink, Peter Reimer, Patrick Adam, Martin Wilhelm, Norbert Schmitz, Christoph Nerl, Andrew Lister, Andrew Norton, Kenneth A MacLennan, Pier Luigi Zinzani, Stefano Pileri, Massimo Federico, Monica Bellei, Bertrand Coiffier, Francoise Berger, Intragumtornchai Tanin, Pongsak Wannakrairot, Wing Au, Raymond Liang, Florence Loong, Sandeep Rajan, Ivy Sng, Kensei Tobinai, Yoshihiro Matsuno, Yasuo Morishima, Shigeo Nakamura, Masao Seto, Mitsune Tanimoto, Tadashi Yoshino, Junji Suzumiya, Koichi Ohshima, Won-Seog Kim, Young-Hyeh Ko
Abstract
The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and treated at their respective centers. Of the 1314 eligible patients, 181 had anaplastic large-cell lymphoma (ALCL; 13.8%) on consensus review: One hundred fifty-nine had systemic ALCL (12.1%) and 22 had primary cutaneous ALCL (1.7%). Patients with anaplastic lymphoma kinase-positive (ALK(+)) ALCL had a superior outcome compared with those with ALK(-) ALCL (5-year failure-free survival [FFS], 60% vs 36%; P = .015; 5-year overall survival [OS], 70% vs 49%; P = .016). However, contrary to prior reports, the 5-year FFS (36% vs 20%; P = .012) and OS (49% vs 32%; P = .032) were superior for ALK(-) ALCL compared with PTCL, not otherwise specified (PTCL-NOS). Patients with primary cutaneous ALCL had a very favorable 5-year OS (90%), but with a propensity to relapse (5-year FFS, 55%). In summary, ALK(-) ALCL should continue to be separated from both ALK(+) ALCL and PTCL-NOS. Although the prognosis of ALK(-) ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course.
Source: PubMed