Author Correction: Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects

Abstract

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Figures

Figure 1

Kansas Criteria for Gulf War Illness scoring form based on Steele7. ©JNBaraniukMD_17g13. Used with permission of the copyright holder.

Figure 2

miRNA differences between post-exercise groups. (a) miR-22-3p was not detectable in most of the START subjects (green squares above the blue line at Ct = 35). START had significantly less miR-22-3p than SC (yellow circles) and STOPP (red diamonds) as indicated by bars over top of the groups (HSD < 0.05, FDR < 0.10). In addition, SC had significantly more miR-22-3p than sc0 (grey circles). (b) miR-9-3p was detected in START, but was found in fewer than two thirds of subjects in the other groups. START had significantly more miRNA expression than STOPP (ΔΔCt = 1.6 ± 1.4, mean ± SD, HSD < 0.05, FDR < 0.10).

Figure 3

miRNAs that were significantly elevated in post-exercise compared to appropriate nonexercise control groups. Significant differences between groups were indicated by the bars at the top of the graphs for (a) miR-99b-5p, (b) miR-425-3p, (c) miR-30d-5p, (d) miR-204-5p, and (e) miR-370 (HSD ≤ 0.05, FDR ≤ 0.10, detected with Ct ≤ 35 in more than two thirds of one group per pair). The horizontal blue line indicated Ct = 35. Mean ± SD.

Figure 4

Decreased (a) miR-328 and (b) miR-608 levels in SC, CFS, START and STOPP groups after exercise.

Figure 5

miRNAs reduced by exercise. GWI phenotypes (START and STOPP) and CFS all had reductions in (a) miR-let-7i-5p, (b) miR-200a-5p and (c) miR-93-3p. Sedentary controls had no changes.

Figure 6

Decreased miRNAs after exercise in CFS group. CFS had significant reductions in -(a) 92a-3p, (b) miR-323b-5p, (c) miR-126-5p, (d) miR-19b-3p, (e) miR-505-3p, (f) miR-532-5p, and (g) miR-186-3p, compared to its nonexercise cfs0 comparison group (bars above the groups).